Advanced Materials,
Год журнала:
2023,
Номер
35(39)
Опубликована: Июль 25, 2023
Tumor-derived
exosomes
(TDEs)
carry
various
biomolecular
cargos
and
play
crucial
roles
in
metastasis.
TDEs
migrate
to
distal
organs
for
intercellular
communication
induce
the
formation
of
pre-metastatic
niches
(PMNs)
support
tumor
implantation
proliferation.
Precise
interference
bioprocess
is
expected
be
efficacious
suppressing
However,
targeting
both
primary
challenging.
Here,
based
on
metabolic
glycoengineering
bio-orthogonal
click
chemistry,
a
two-step
delivery
strategy
designed
overcome
this.
During
first
step,
tetraacetylated
N-azidoacetyl-d-mannosamine-loaded
nanoparticle
responds
activity
cells
tumor,
tagging
with
azide
groups;
dibenzyl-cyclootyne-modified
nanoparticles
then
can,
as
second
specifically
react
through
reaction.
This
not
only
inhibits
growth
pancreatic
cancer
models
but
also
curbs
communicative
role
inducing
liver
PMNs
metastasis
by
tracking
downregulating
exosomal
macrophage
migration
inhibitory
factor.
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
62(33)
Опубликована: Май 11, 2023
Photoresponsive
materials
offer
excellent
spatiotemporal
control
over
biological
processes
and
the
emerging
phototherapeutic
methods
are
expected
to
have
significant
effects
on
targeted
cancer
therapies.
Recent
examples
show
that
combination
of
photoactivatable
approaches
with
bioorthogonal
chemistry
enhances
precision
phototherapies
profound
implications
foreseen
particularly
in
treatment
disperse/diffuse
tumors.
The
extra
level
on-target
selectivity
improved
spatial/temporal
considerably
intensified
related
bioorthogonally
assisted
phototherapy
research.
anticipated
growth
further
developments
field
justifies
timeliness
a
brief
summary
state
art.
Biomacromolecules,
Год журнала:
2023,
Номер
24(2), С. 1022 - 1031
Опубликована: Янв. 12, 2023
Although
traditional
nanomedicines
have
enhanced
the
therapeutic
efficacy
and
improved
survival
quality
of
cancer
patients,
random
drug
release
resistance
are
deep-rooted
problems
hindering
their
clinical
application.
A
precise
nanoplatform
combing
chemotherapy
photodynamic
therapy
(PDT)
is
developing
as
a
new
strategy
to
overcome
above
challenges.
Herein,
novel
supramolecular
nanomedicine
ingeniously
constructed
for
in
situ
self-boosting
photochemotherapy.
Hydrophilic
polyethylene
glycol
(PEG)
chains
or
β-cyclodextrin
(β-CD)
hosts
first
conjugated
onto
tetraphenyl
porphyrin
(TCPP)
improve
solubility
TCPP
decrease
π–π
stacking
interactions,
guaranteeing
high-efficiency
PDT.
Then,
two
camptothecin
(CPT)
molecules
linked
together
via
reactive
oxygen
species
(ROS)-responsive
thioketal
bond,
which
averts
premature
burst
CPT
realizes
at
tumor
site
where
PDT
performed,
resulting
an
chemotherapy.
Benefiting
from
collaboration
host–guest
complexation
between
β-CD
CPT,
multiple
intermolecular
hydrogen
bonds
β-CD,
interactions
among
well
PEG
shell
protection,
prolonged
blood
circulation
time,
selective
accumulation
acquired,
facilitate
synergistic
photochemotherapy
bring
pre-eminent
antitumor
response
with
low
systemic
toxicity.
Abstract
Peptide
and
protein
postmodification
have
gained
significant
attention
due
to
their
extensive
impact
on
biomolecule
engineering
drug
discovery,
of
which
cysteine‐specific
modification
strategies
are
prominent
inherent
nucleophilicity
low
abundance.
Herein,
the
study
introduces
a
novel
approach
utilizing
multifunctional
5‐substituted
1,2,3‐triazine
derivatives
achieve
multifaceted
bioconjugation
targeting
cysteine‐containing
peptides
proteins.
On
one
hand,
this
represents
an
inaugural
instance
employing
in
biomolecular‐specific
within
physiological
solution.
other
as
powerful
combination
precision
biorthogonality,
strategy
allows
for
one‐pot
dual‐orthogonal
functionalization
biomolecules
aldehyde
group
generated
simultaneously.
1,2,3‐Triazine
with
diverse
functional
groups
allow
conjugation
or
proteins,
while
bi‐triazines
enable
peptide
cyclization
dimerization.
The
examination
stability
revealed
potential
reversible
modification.
This
work
establishes
comprehensive
platform
identifying
cysteine‐selective
modifications,
providing
new
avenues
peptide‐based
development,
bioconjugation,
chemical
biology
research.
Progress in Polymer Science,
Год журнала:
2022,
Номер
133, С. 101590 - 101590
Опубликована: Авг. 9, 2022
Recent
advances
in
materials
science
and
engineering
highlight
the
importance
of
designing
sophisticated
biomaterials
with
well-defined
architectures
tunable
properties
for
emerging
biomedical
applications.
Click
chemistry,
a
powerful
method
allowing
specific
controllable
bioorthogonal
reactions,
has
revolutionized
our
ability
to
make
complex
molecular
structures
high
level
specificity,
selectivity,
yield
under
mild
conditions.
These
features
combined
minimal
byproduct
formation
have
enabled
design
wide
range
macromolecular
from
quick
versatile
click
reactions.
Furthermore,
copper-free
chemistry
resulted
change
paradigm,
researchers
perform
highly
selective
chemical
reactions
biological
environments
further
understand
structure
function
cells.
In
living
systems,
introducing
clickable
groups
into
biomolecules
such
as
polysaccharides
(PSA)
been
explored
general
approach
conduct
medicinal
potentially
help
solve
healthcare
needs.
De
novo
biosynthetic
pathways
synthesis
also
exploited
optimized
PSA-based
bioconjugation
inside
cells
without
interfering
their
native
processes
or
functions.
This
strategy
obviates
need
laborious
costly
which
normally
require
extensive
time-consuming
purification
steps.
Using
these
approaches,
various
macromolecules
manufactured
building
blocks
novel
biomaterials.
Clickable
PSA
provides
toolbox
scientists
will
increasingly
play
crucial
role
field.
Specifically,
bioclick
leveraged
advanced
drug
delivery
systems
minimally
invasive
injectable
hydrogels.
this
review
article,
we
outlined
key
aspects
breadth
PSA-derived
polymeric
applications
imaging,
delivery,
tissue
engineering.
Additionally,
discussed
past
achievements,
present
developments,
recent
trends
3D
printing,
well
challenges,
clinical
translatability,
future
perspectives.
ACS Nano,
Год журнала:
2022,
Номер
16(12), С. 20975 - 20984
Опубликована: Ноя. 17, 2022
As
a
burgeoning
bioorthogonal
reaction,
the
fluoride-mediated
desilylation
is
capable
of
prodrug
activation.
However,
due
to
reactions
lack
cell
selectivity
and
unitary
therapy
modality,
this
strongly
impedes
their
biomedical
applications.
Herein,
we
construct
cancer
cell-selective
biomimetic
metal–organic
framework
(MOF)-F
platform
for
activation
enhanced
synergistic
chemodynamic
(CDT).
With
membranes
camouflage,
designed
nanocatalyst
displays
preferential
accumulation
homotypic
cells.
Then,
pH-responsive
releases
fluoride
ions
ferric
ions.
For
our
tert-butyldimethyl
silyl
(TBS)-hydroxycamptothecin
(TBSO-CPT),
can
desilylate
TBS
cleave
ether
linker
synthesize
OH-CPT
(10-hydroxycamptothecin)
drug
molecule,
which
effectively
kills
Intriguingly,
bioorthogonal-synthesized
upregulates
intracellular
H2O2
by
activating
nicotinamide
adenine
dinucleotide
phosphate
oxidase
(NOX),
amplifying
released
iron
induced
Fenton
reaction
CDT.
Both
in
vitro
vivo
studies
demonstrate
strategy
presents
versatile
fluoride-activated
catalyst
synthesis.
Our
work
may
accelerate
applications
chemistry.
