Recent Advances in Green Multi-Component Reactions for Heterocyclic Compound Construction

Organic & Biomolecular Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

This review highlights the recent advances in multi-component reactions for synthesizing heterocyclic compounds via green approaches including photoredox catalysis, electrochemical activation, catalyst-free methods and use of water as sole solvent.

Язык: Английский

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Application of novel Fe3O4/Zn-metal organic framework magnetic nanostructures as an antimicrobial agent and magnetic nanocatalyst in the synthesis of heterocyclic compounds

Frontiers in Chemistry, Год журнала: 2022, Номер 10

Опубликована: Окт. 10, 2022

Using the microwave-assisted method, novel Fe3O4/Zn-metal organic framework magnetic nanostructures were synthesized. The crystallinity, thermal stability, adsorption/desorption isotherms, morphology/size distribution, and hysteresis of synthesized characterized by XRD patterns, TGA curve, BET technique, SEM image, VSM respectively. After confirming nanostructures, its antimicrobial properties against Gram-positive bacterial, Gram-negative fungal strains based on minimum inhibitory concentration (MIC), bactericidal (MBC), fungicidal (MFC) values studied. MIC in activity for bacterial strains, between 16-128 μg/ml, strain, 128 μg/ml observed. results showed that high specific surface area caused power nanoparticles to be high, observed effects higher than some known commercial drugs. Another advantage was catalytic three-component reaction isatin, malononitrile, dimedone. New spiro [indoline-pyranopyrimidines] derivatives with efficiency. that, addition recyclability, could less time previously reported methods. investigating range 10-20 min an efficiency over 85%. As a final result, it can concluded microwave synthesis method improves unique especially area, has increased

Язык: Английский

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Metal-Free Photoredox Four-Component Strategy to 1,3-Functionalized BCP Derivatives

Organic Letters, Год журнала: 2023, Номер 25(28), С. 5308 - 5313

Опубликована: Июль 7, 2023

Trifluoromethyl bicyclo[1.1.1]pentanes (BCPs) have attracted significant attention from the scientific community and pharmaceutical industries due to their advantageous physicochemical properties as arene bioisosteres. Initial photoredox perfluoroalkylation of [1.1.1]propellane triggers tandem reaction perfluoroalkyl BCP radical followed by Giese addition an in situ generated electron-deficient alkene Knoevenagel condensation a four-component fashion form 1,3-functionalized BCPs. This strategy provides easy access various derivatives with added advantage nitrile group functional handle diversified transformations. methodology offers scalability late-stage derivatization drug molecules high chemoselectivity.

Язык: Английский

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Photocatalytic C−C Cleavage of Methylenecyclobutanes for γ,δ‐Unsaturated Aldehydes by Strain Release

Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(22)

Опубликована: Март 6, 2023

Radical additions onto olefins have surfaced as an increasingly powerful strategy for the synthesis of difunctionalized scaffolds. However, despite major advances, known approaches continue to be largely limited two manifolds, namely 1,2-difunctionalization alkenes and remote difunctionalization via hydrogen atom transfer (HAT). Herein, we describe a mechanistically distinct approach by photoinduced carbon-carbon (C-C) activation/ring-opening access γ,δ-unsaturated aldehydes from methylenecyclobutanols sulfonyl chlorides strain release. Remarkably, motif on products was easily removed another photocatalytic process, which enabled concise assembly natural product alatanone A. The synthetic utility our reflected versatile functional group tolerance, ample substrate scope, scalability. photocatalysis represents conceptually alternative existing 1,4-diversifications, with double bond remaining in thus obtained products.

Язык: Английский

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Paraformaldehyde as C1 Synthon: Electrochemical Three‐Component Synthesis of Tetrahydroimidazo[1,5‐a]quinoxalin‐4(5H)‐ones in Aqueous Ethanol

ChemSusChem, Год журнала: 2023, Номер 16(19)

Опубликована: Сен. 20, 2023

A green and practical method for the electrochemical synthesis of tetrahydroimidazo[1,5-a]quinoxalin-4(5H)-ones through three-component reaction quinoxalin-2(1H)-ones, N-arylglycines paraformaldehyde was reported. In this strategy, EtOH played dual roles (eco-friendly solvent waste-free pre-catalyst) in situ generated ethoxide promoted triple sequential deprotonations.

Язык: Английский

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