Abstract
The
combination
of
photodynamic
therapy
(PDT)
and
chemotherapy
(chemo‐photodynamic
therapy)
for
enhancing
cancer
therapeutic
efficiency
has
attracted
tremendous
attention
in
the
recent
years.
However,
limitations,
such
as
low
local
concentration,
non‐suitable
treatment
light
source,
uncontrollable
release
agents,
result
reduced
combined
efficacy.
This
study
considered
adenosine
triphosphate
(ATP),
which
is
highly
upregulated
tumor
cells,
a
biomarker
developed
ingenious
ATP‐activated
nanoparticles
(CDNPs)
that
are
directly
self‐assembled
from
near‐infrared
photosensitizer
(Cy‐I)
amphiphilic
Cd(II)
complex
(DPA‐Cd).
After
selective
entry
into
positively
charged
CDNPs
would
escape
lysosomes
be
disintegrated
by
high
ATP
concentration
cytoplasm.
released
Cy‐I
capable
producing
single
oxygen
(
1
O
2
)
PDT
with
808
nm
irradiation
DPA‐Cd
can
concurrently
function
chemotherapy.
Irradiation
lead
to
ablation
tumor‐bearing
mice
after
intravenous
injection
CDNPs.
carrier‐free
nanoparticle
offers
new
platform
chemo‐photodynamic
therapy.
Chemical Society Reviews,
Год журнала:
2022,
Номер
51(15), С. 6307 - 6416
Опубликована: Янв. 1, 2022
This
review
highlights
the
recent
advances
of
metalated
covalent
organic
frameworks,
including
synthetic
strategies
and
applications,
discusses
current
challenges
future
directions.
Materials Horizons,
Год журнала:
2023,
Номер
10(10), С. 4083 - 4138
Опубликована: Янв. 1, 2023
Porous
organic
polymers
show
great
potential
for
addressing
environmental
pollution
challenges,
including
chemical
sensing,
wastewater
treatment,
toxic
gas
sorption,
heterogeneous
catalysis,
and
further
promoting
sustainable
remediation
strategies.
Journal of the American Chemical Society,
Год журнала:
2022,
Номер
144(51), С. 23534 - 23542
Опубликована: Дек. 13, 2022
Polyimide
covalent
organic
framework
(PI-COF)
materials
that
can
realize
intrinsic
redox
reactions
by
changing
the
charge
state
of
their
electroactive
sites
are
considered
as
emerging
electrode
for
rechargeable
devices.
However,
highly
crystalline
PI-COFs
with
hierarchical
porosity
less
reported
due
to
rapid
reaction
between
monomers
and
poor
reversibility
polyimidization
reaction.
Here,
we
developed
a
water-assistant
synthetic
strategy
adjust
rate
polyimidization,
PI-COF
(COFTPDA-PMDA)
kgm
topology
consisting
dual
active
centers
N,N,N′,N′-tetrakis(4-aminophenyl)-1,4-benzenediamine
(TPDA)
pyromellitic
dianhydride
(PMDA)
ligands
was
successfully
synthesized
high
crystallinity
porosity.
The
COFTPDA-PMDA
possesses
micro-/mesoporous
channels
largest
surface
area
(2669
m2/g)
in
PI-COFs,
which
promote
Li+
ions
bulky
bis(trifluoromethanesulfonyl)imide
(TFSI–)
electrolyte
sufficiently
interact
on
COF
skeleton
increase
specific
capacity
cathode
materials.
As
material
lithium-ion
batteries,
COFTPDA-PMDA@50%CNT
integrated
center
carbon
nanotubes
via
π–π
interactions
gave
initial
233
mAh/g
(0.5
A/g)
maintains
at
80
even
current
density
5.0
A/g
after
1800
cycles.
Chemistry of Materials,
Год журнала:
2023,
Номер
35(7), С. 2661 - 2682
Опубликована: Март 24, 2023
The
insolubility
in
solvents
and
poor
processability
of
powder
covalent
organic
frameworks
(COFs)
considerably
impede
their
practical
application.
To
address
these
issues
bridge
the
gap
between
COFs
application,
construction
monolithic
has
emerged
as
a
feasible
effective
solution.
Monolithic
(i.e.,
macroscopic
three-dimensional
architectures)
with
hierarchical
structures
have
attracted
tremendous
interest
for
environmental
remediation
exhibited
good
contaminant
removal
performances
owing
to
wide
distribution
pore
sizes
ranging
from
micropores
macropores,
large
specific
surface
area,
tailored
chemical
components,
excellent
stability.
can
be
either
pure
self-supporting
or
composites
other
materials.
resulting
COF-based
monoliths
inherit
merits
parent
(such
tunable
size,
structure,
super
chemical/thermal
stability)
intriguing
features
materials,
such
high
porosity,
easy
handling,
endowing
them
fast
mass
transfer
adsorption
capacity.
This
review
provides
comprehensive
summary
recent
advances
synthesis
COF
Additionally,
progress
application
is
summarized,
including
metal-ion
removal,
organic-pollutant
capture,
oil–water
separation.
Furthermore,
this
discusses
current
challenges
future
perspectives.
We
sincerely
hope
that
it
will
contribute
further
development
materials
fields,
especially
remediation.
Bioactive Materials,
Год журнала:
2022,
Номер
21, С. 358 - 380
Опубликована: Сен. 14, 2022
Nanomedicines
for
drug
delivery
and
imaging-guided
cancer
therapy
is
a
rapidly
growing
research
area.
The
unique
properties
of
nanomedicines
have
massive
potential
in
solving
longstanding
challenges
existing
drugs,
such
as
poor
localization
at
the
tumor
site,
high
doses
toxicity,
recurrence,
immune
response.
However,
inadequate
biocompatibility
restricts
their
clinical
translation.
Therefore,
advanced
nanomaterials
with
enhanced
therapeutic
efficiency
are
highly
desired
to
fast-track
translation
nanomedicines.
Intrinsic
nanoscale
covalent
organic
frameworks
(nCOFs),
suitable
size,
modular
pore
geometry
porosity,
straightforward
post-synthetic
modification
via
simple
transformations,
make
them
incredibly
attractive
future
ability
COFs
disintegrate
slightly
acidic
microenvironment
also
gives
competitive
advantage
targeted
delivery.
This
review
summarizes
recently
published
applications
delivery,
photo-immuno
therapy,
sonodynamic
photothermal
chemotherapy,
pyroptosis,
combination
therapy.
Herein
we
mainly
focused
on
modifications
enhance
biocompatibility,
efficacy
will
provide
fundamental
knowledge
designing
biocompatible
nCOFs-based
help
rapid
development
carriers
theranostics.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Янв. 3, 2024
Abstract
Successful
oral
insulin
administration
can
considerably
enhance
the
quality
of
life
(QOL)
diabetes
patients
who
must
frequently
take
injections.
Oral
administration,
on
other
hand,
is
seriously
hampered
by
gastrointestinal
enzymes,
wide
pH
range,
mucus
and
mucosal
layers,
which
limit
bioavailability
to
≤
2%.
Therefore,
a
large
number
technological
solutions
have
been
proposed
increase
insulin,
in
polymeric
nanoparticles
(PNPs)
are
highly
promising
for
delivery.
The
recently
published
research
articles
chosen
this
review
based
applications
PNPs
with
strong
future
potential
delivery,
do
not
cover
all
related
work.
In
review,
we
will
summarize
controlled
release
mechanisms
latest
delivery
nanocarrier,
challenges
prospect.
This
serve
as
guide
investigators
wish
engineer
study
systems.
Graphical
Journal of Polymer Science,
Год журнала:
2023,
Номер
62(8), С. 1517 - 1535
Опубликована: Авг. 2, 2023
Abstract
Hyper‐crosslinked
polymers
(HCPs)
are
a
family
of
that
possess
several
desirable
characteristics,
including
high
specific
surface
area,
excellent
stability,
tunable
porous
structures,
and
low‐cost
reagents.
As
result,
HCPs
have
gained
significant
attention
in
the
areas
gas
storage,
adsorption,
catalysis,
separation,
carbon
precursors,
exhibiting
advanced
performances
catalytic
energy‐related
applications.
Recently,
researchers
explored
potential
biomedical
engineering.
In
this
review,
we
discuss
classical
synthesis
strategies
morphological
assembly
methods
used
to
create
with
unique
biological
properties.
We
also
highlight
latest
advances
emerging
HCPs,
such
as
drug
delivery,
antimicrobial,
bioimaging,
biosensing.
By
providing
various
examples,
further
correlations
between
morphologies,
enhanced
properties
HCPs.
Finally,
summarize
key
applications
provide
an
outlook
on
research
direction
encourage
development
biomedically
available
Overall,
offer
promising
new
class
materials
for
use
applications,
continued
field
will
lead
exciting
discoveries
breakthroughs.
