Abstract
The
combination
of
photodynamic
therapy
(PDT)
and
chemotherapy
(chemo‐photodynamic
therapy)
for
enhancing
cancer
therapeutic
efficiency
has
attracted
tremendous
attention
in
the
recent
years.
However,
limitations,
such
as
low
local
concentration,
non‐suitable
treatment
light
source,
uncontrollable
release
agents,
result
reduced
combined
efficacy.
This
study
considered
adenosine
triphosphate
(ATP),
which
is
highly
upregulated
tumor
cells,
a
biomarker
developed
ingenious
ATP‐activated
nanoparticles
(CDNPs)
that
are
directly
self‐assembled
from
near‐infrared
photosensitizer
(Cy‐I)
amphiphilic
Cd(II)
complex
(DPA‐Cd).
After
selective
entry
into
positively
charged
CDNPs
would
escape
lysosomes
be
disintegrated
by
high
ATP
concentration
cytoplasm.
released
Cy‐I
capable
producing
single
oxygen
(
1
O
2
)
PDT
with
808
nm
irradiation
DPA‐Cd
can
concurrently
function
chemotherapy.
Irradiation
lead
to
ablation
tumor‐bearing
mice
after
intravenous
injection
CDNPs.
carrier‐free
nanoparticle
offers
new
platform
chemo‐photodynamic
therapy.
ACS Materials Letters,
Год журнала:
2023,
Номер
5(2), С. 466 - 472
Опубликована: Янв. 13, 2023
Metal–organic
frameworks
are
smart
carriers
for
controlled
drug
delivery
due
to
large
surface
area
and
adjustable
pore
size.
Current
approaches
can
hardly
utilize
the
space
of
MOFs
thoroughly,
greatly
causing
waste
space.
Here,
Pore
Space
Partition
(PSP)
approach
was
employed
achieve
effective
encapsulation
pH-controlled
codelivery
two
guest
molecules.
The
ZIF-8
partitioned
by
molecule
ursolic
acid
(UA),
remaining
filled
with
small
5-fluorouracil
(5-FU),
obtaining
5-FU&UA@ZIF-8
high
loading
capacity
UA
(12.80
wt
%)
5-FU
(11.20
%).
Accompanied
collapse
in
acidic
surroundings,
exhibited
delivery.
To
our
surprise,
also
showed
pH
responsive
delivery,
which
did
not
exist
before
partition
UA.
Codelivery
enable
have
good
anticancer
performance
against
4T1
cells.
Chemical Society Reviews,
Год журнала:
2023,
Номер
52(18), С. 6447 - 6496
Опубликована: Янв. 1, 2023
This
review
highlights
the
use
of
nanoprobes
to
stratify
various
therapeutic
modalities
and
provides
an
outlook
on
challenges
future
directions
for
patient
stratification.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(28)
Опубликована: Фев. 15, 2024
Abstract
Photocatalytic
oxygen
(O
2
)
reduction
to
hydrogen
peroxide
(H
O
is
considered
be
a
promising
method
for
energy
storage.
However,
it
suffers
from
the
rapid
recombination
of
carriers,
limited
solubility
and
slow
diffusion
,
self‐decomposition
H
in
traditional
diphase
systems.
Here,
self‐floating
carbon
dots/conjugated
microporous
polymer
(CDs/CMP)
photocatalytic
system
established
production
organic
synthesis.
Due
D–π–A
structure,
porous
hydrophobicity,
CMP
induced
intramolecular
charge
transfer,
exposed
abundant
reaction
sites,
enhanced
adsorption.
CDs
act
as
“bridges”
electron
transmission
regulate
surface
hydrophobicity
CMP,
further
improving
transfer
optimizing
interface.
CDs/CMP
exhibits
high
8542.6
µmol
g
−1
h
concurrent
furoic
acid
at
2.22
m
.
This
rate
≈90%
higher
than
that
system,
exceeding
all
previously
reported
photocatalysts
triphase
Notably,
achieves
relative
separation
suppressing
generated
self‐decomposition.
Theoretical
calculations
situ
characterizations
reveal
mechanism
evolution.
provides
insights
into
exploring
application
metal‐free
heterogeneous
reactions.
Abstract
The
development
of
efficient
drug
delivery
systems
is
essential
for
improving
the
efficacy
and
safety
cancer
drugs,
particularly
aggressive
difficult‐to‐treat
cancers.
Covalent
organic
frameworks
(COFs)
are
emerging
as
innovative
porous
nanomaterials
in
(DDS),
due
to
their
unique
properties,
including
metal‐free
skeleton,
predetermined
structures
pore
geometries,
high
porosity,
large
surface
area,
facile
modification
potential,
good
biocompatibility.
These
characteristics
make
COFs
excellent
candidates
by
enhancing
loading
capacity
enabling
precise
encapsulation.
This
review
emphasizes
importance
donor‐acceptor‐based
COFs,
which
provide
channels
charge
transportation,
we
also
explore
how
π‐conjugated
skeleton
enhances
its
long‐acting
fluorescent
properties
facilitates
uptake
via
cell
endocytosis.
While
this
primarily
focuses
on
recent
advancements
COF‐based
targeted
DDS,
it
acknowledges
challenges
posed
diverse
geometries
materials
discusses
potential
solutions.
Further,
underlines
developing
future
carriers
that
can
successfully
specifically
target
cells,
treatment
efficiency
while
reducing
adverse
side
effects.
Materials Horizons,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
This
review
systematically
examines
the
structural
features,
fabrication
techniques,
and
applications
of
porous
polymers,
as
well
their
interrelationships,
to
serve
a
guide
for
researchers.
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Янв. 2, 2025
The
discovery
of
tertiary
lymphoid
structures
(TLS)
within
tumor
tissues
provides
a
promising
avenue
to
promote
the
efficacy
cancer
immunotherapy.
Yet,
lack
effective
strategies
induce
TLS
formation
poses
substantial
obstacle.
Thus,
exploration
potential
inducers
for
is
great
interest
but
remains
challenging.
Here,
inspired
by
mechanism
artificially
cultivated
pearls,
covalent
organic
framework
(COF)
employed
formation.
Single-cell
sequencing
analysis
reveals
that
this
achieved
promotion
cytokine
hypersecretion,
which
facilitates
maturation,
proliferation,
and
migration
T
B
cells,
critical
triggering
Furthermore,
COF-mediated
phototherapy
in
inducing
validated
both
MC38
4MOSC1
female
models.
Notably,
strong
synergistic
effect
between
αCTLA-4
observed,
resulting
eradication
primary
distant
tumors,
while
also
inhibiting
recurrence.
boosting
immunotherapy,
it
challenging
develop
authors
report
able
trigger
Journal of Materials Chemistry B,
Год журнала:
2022,
Номер
11(3), С. 482 - 499
Опубликована: Ноя. 21, 2022
Periodontitis
is
defined
as
a
chronic
inflammatory
disease
in
which
the
continuous
activation
of
oxidative
stress
surpasses
reactive
oxygen
species
(ROS)
scavenging
capacity
endogenous
antioxidative
defense
system.
Studies
have
demonstrated
that
ROS-scavenging
biomaterials
should
be
promising
candidates
for
periodontitis
therapy.
To
benefit
understanding
and
design
periodontitis,
this
review
details
relationship
between
ROS
including
direct
indirect
damage,
application
organic
inorganic
biomaterials,
various
dosage
forms
fabricated
materials
currently
used
periodontal
Finally,
current
situation
further
prospects
applications
are
summarized.
Expecting
improved
could
better
designed
developed
even
clinical
application.
