Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Авг. 3, 2023
Abstract
Liver
fibrosis
is
one
of
the
main
threats
to
human
health.
To
date,
antifibrosis
drugs
encompass
several
problems,
such
as
limited
treatment
effects,
lack
drug
targeting,
and
toxic
side
effects.
increase
therapeutic
efficacy
in
targeting
liver
fibrosis,
scientists
should
study
development
nanocarriers
effective
strategies
for
fibrosis.
In
this
study,
Fe
3
O
4
/SiO
2
/curcumin
(Cur)
nanohybrid
composites
have
been
successfully
synthesized
used
animal
cells,
which
were
induced
with
carbon
tetrachloride
(CCl
).
The
composition,
shape,
size,
magnetic
properties
nanocarrier
contributed
successful
antifibrotic
agents.
Structural
studies
using
X-ray
diffraction,
Fourier
transform
infrared
spectroscopy,
scanning
electron
microscopy–energy
dispersive
X-ray,
transmission
microscopy
also
carried
out.
sensitivity
external
field
tested
vibrating
sample
magnetometry.
Furthermore,
preclinical
tests
form
antibacterial
antifungal
performed.
From
these
characterizations,
/Cur
showed
good
inhibition
bacterial
fungal
growth.
determine
composites,
we
conducted
serum
glutamic
oxaloacetic
transaminase
hytests.
Notably,
significantly
reduced
alanine
aspartate
levels
(p
<
0.05).
Thus,
can
reduce
CCl
-induced
injury.
ACS Nano,
Год журнала:
2024,
Номер
18(8), С. 6445 - 6462
Опубликована: Фев. 15, 2024
Tumor-associated
macrophages
(TAMs)
are
closely
related
to
the
progression
of
glioblastoma
multiform
(GBM)
and
its
development
therapeutic
resistance
conventional
chemotherapy.
TAM-targeted
therapy
combined
with
chemotherapy
has
emerged
as
a
promising
strategy
combat
GBM.
However,
presence
blood–brain
barrier
(BBB)
severely
limits
efficacy.
Meanwhile,
lack
ability
distinguish
different
targeted
cells
also
poses
challenge
for
precise
therapy.
Herein,
we
propose
cathepsin
B
(CTSB)-responsive
programmed
brain-targeted
delivery
system
(D&R-HM-MCA)
simultaneous
GBM-targeted
delivery.
D&R-HM-MCA
could
cross
BBB
via
low
density
lipoprotein
receptor-associated
protein
1
(LRP1)-mediated
transcytosis.
Upon
reaching
GBM
site,
outer
angiopep-2
modification
be
detached
from
cleavage
CTSB-responsive
peptide,
which
circumvent
abluminal
LRP1-mediated
efflux.
The
exposed
p-aminophenyl-α-d-mannopyranoside
(MAN)
further
recognize
glucose
transporter-1
(GLUT1)
on
macrophage
mannose
receptor
(MMR)
TAMs.
achieve
chemotherapeutic
killing
simultaneously
induce
TAM
polarization
anti-inflammatory
M2
phenotype
pro-inflammatory
M1
phenotype,
thus
resensitizing
response
improving
anti-GBM
immune
response.
This
not
only
can
improve
brain
efficiency,
but
enable
combination
chemo-immunotherapy
against
effectiveness
this
may
provide
thinking
designing
more
functional
systems
effective
regimens.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Окт. 12, 2024
Endothelial
cells
(ECs)
are
pivotal
in
maintaining
vascular
health,
regulating
hemodynamics,
and
modulating
inflammatory
responses.
Nanocarriers
hold
transformative
potential
for
precise
drug
delivery
within
the
system,
particularly
targeting
ECs
therapeutic
purposes.
However,
complex
interactions
between
nanocarriers
present
significant
challenges
development
clinical
translation
of
nanotherapeutics.
This
review
assesses
recent
advancements
key
strategies
employing
to
ECs.
It
suggested
that
through
physicochemical
design
surface
modifications,
can
enhance
specificity
improve
internalization
efficiency
Additionally,
we
elaborated
on
applications
specifically
designed
treatment
cardiovascular
diseases,
cancer
metastasis,
disorders.
Despite
these
advancements,
safety
concerns,
complexity
vivo
processes,
challenge
achieving
subcellular
remain
obstacles
effective
with
nanocarriers.
A
comprehensive
understanding
endothelial
cell
biology
its
interaction
is
crucial
realizing
full
targeted
systems.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 30, 2025
Abstract
Intranasal
delivery
of
mRNA
vaccines
offers
promising
opportunities
to
combat
airborne
viruses
like
SARS‐CoV‐2
by
provoking
mucosal
immunity,
which
not
only
defends
against
respiratory
infection
but
also
prevents
contagious
transmission.
However,
the
development
nasal
has
been
hampered
lack
effective
means
overcome
mucus
barrier.
Herein,
ionizable
lipid‐incorporated
liquid
lipid
nanoparticles
(iLLNs)
capable
delivering
cargo
across
airway
mucosa
are
designed.
Adjusting
ratios
and
cationic
lipids
allows
fine‐tuning
p
K
a
iLLNs
range
pH
(5.5–6.5),
thus
facilitating
penetration
via
formation
near‐neutral,
PEGylated
muco‐inert
surfaces.
When
nasally
administered
mice,
top
candidate
iLLN‐2/mRNA
complexes
enable
about
60‐fold
greater
reporter
gene
expression
in
cavity,
compared
benchmark
mRNA‐lipid
(ALC‐LNP)
having
same
composition
as
that
BNT162b2
vaccine.
Moreover,
prime‐boost
intranasal
immunization
elicits
magnitude
spike‐specific
IgA
IgG
response
than
ALC‐LNP,
without
triggering
any
noticeable
inflammatory
reactions.
Taken
together,
these
results
provide
useful
insights
for
design
deliverable
formulations
prophylactic
applications.
ACS Chemical Biology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 13, 2025
Glioblastoma
multiforme
(GBM)
is
a
WHO
grade
4
glioma
and
the
most
common
malignant
primary
brain
tumor.
Addressing
clinical
management
of
GBM
presents
an
exceptionally
daunting
intricate
challenge,
particularly
in
overcoming
blood–brain
barrier
(BBB)
to
deliver
effective
therapies
brain.
Nanotechnology-based
drug
delivery
systems
have
exhibited
considerable
promise
tackling
this
aggressive
cancer.
However,
BBB
remains
key
challenge
achieving
nanocarriers.
Here,
we
optimized
lipid
nanoparticle
(LNP)
formulation
(C2)
modified
LNP
with
Angiopep-2
peptide,
which
exhibits
significant
improvements
penetration
accumulation
(about
2.23%
injection
dose).
Using
Ang-2-coupled
C2
formulation,
researched
therapeutic
effect
Polo-like
Kinase
1(PLK1)-targeted
siRNA
treat
mouse
model
GBM.
The
was
demonstrated
significantly
inhibit
growth
extend
median
survival
mice
(2.18-fold).
This
work
demonstrates
efficacy
brain-targeted
system
treatment.
As
understanding
role
RNAs
deepens
innovative
methods
are
continually
developed
refined,
RNA-based
could
emerge
as
crucial
breakthrough
advancement
tumor
Frontiers in Nutrition,
Год журнала:
2024,
Номер
11
Опубликована: Июль 29, 2024
Polyphenols
are
a
group
of
naturally
occurring
compounds
that
possess
range
biological
properties
capable
potentially
mitigating
or
preventing
the
progression
age-related
cognitive
decline
and
Alzheimer's
disease
(AD).
AD
is
chronic
neurodegenerative
known
as
one
fast-growing
diseases,
especially
in
elderly
population.
Moreover,
primary
etiology
dementia,
it
poses
challenges
for
both
familial
societal
structures,
while
also
imposing
significant
economic
strain.
There
currently
no
pharmacological
intervention
has
demonstrated
efficacy
treating
AD.
While
polyphenols
have
exhibited
potential
inhibiting
pathological
hallmarks
AD,
their
limited
bioavailability
challenge
therapeutic
application.
Furthermore,
order
to
address
constraints,
several
polymer
nanoparticles
being
explored
improved
delivery
systems
optimize
pharmacokinetic
characteristics
polyphenols.
Polymer
advantageous
facilitating
across
blood-brain
barrier,
resulting
efficient
distribution
within
brain.
This
review
focuses
on
amyloid-related
diseases
role
them,
addition
discussing
anti-amyloid
effects
applications
polyphenol-based
nanoparticles.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 6, 2024
Bottlebrush
copolymers
are
increasingly
used
for
drug
delivery
and
biological
imaging
applications
in
part
due
to
the
enhanced
thermodynamic
stability
of
their
self-assemblies.
Herein,
we
discuss
effect
hydrophilic
block
chemistry
on
bottlebrush
micelles.
Amphiphilic
bottlebrushes
with
zwitterionic
poly(2-methacryloyloxyethyl
phosphorylcholine)
(PMPC)
nonionic
polyethylene
glycol
(PEG)
blocks
were
synthesized
by
"grafting
from"
polymerization
self-assembled
into
well-defined
spherical
Colloidal
against
disassembly
challenged
under
high
concentrations
NaCl,
MgSO
Journal of Nanobiotechnology,
Год журнала:
2023,
Номер
21(1)
Опубликована: Сен. 4, 2023
Abstract
Second
near-infrared
(NIR-II)
fluorescence
imaging
in
the
range
of
1000–1700
nm
has
great
prospects
for
vivo
and
theranostics
monitoring.
At
present,
few
NIR-II
probes
with
properties
have
been
developed,
especially
high-performance
organic
material
remains
underexploited.
Herein,
we
demonstrate
a
selenium
(Se)-tailoring
method
to
develop
high-efficient
imaging-guided
cancer
phototheranostics.
Via
Se-tailoring
strategy,
conjugated
oligomer
TPSe-based
nanoparticles
(TPSe
NPs)
achieve
bright
emission
up
1400
exhibit
relatively
high
photothermal
conversion
efficiency
60%
good
stability.
Moreover,
TPSe
NPs
their
ablation
cells
vitro
tumor
guidance
imaging.
It
is
worth
noting
that
biocompatibility
without
obvious
side
effects.
Thus,
this
work
provides
new
insight
into
development
agents.
