Organic Letters,
Год журнала:
2024,
Номер
26(10), С. 2057 - 2061
Опубликована: Март 1, 2024
In
this
paper,
palladium-catalyzed
[3
+
2]
cycloaddition
of
4-vinyl-4-butyrolactones
with
ketenes
generated
from
easily
available
acyl
chlorides
was
achieved.
With
Pd2(dba)3·CHCl3/XantPhos
as
the
catalyst,
reaction
proceeded
smoothly
under
mild
conditions,
affording
a
series
2,3-dihydrofurans
in
moderate
to
high
yields.
The
scale-up
and
further
transformations
products
are
demonstrated,
plausible
mechanism
is
proposed
well.
Advanced Synthesis & Catalysis,
Год журнала:
2022,
Номер
364(22), С. 3967 - 3972
Опубликована: Окт. 18, 2022
Abstract
In
this
paper,
we
designed
and
synthesized
4‐vinyl‐4‐butyrolactone
as
a
precursor
to
generate
the
zwitterionic
allylpalladium
intermediates,
which
behaved
five‐membered
all‐carbon
synthon
in
palladium‐catalyzed
(5+3)
annulation
with
azomethine
imines,
giving
eight‐membered
ring‐fused
heterocycles
(26
examples,
49%
97%
yield,
>20:1
dr).
magnified
image
Chinese Journal of Organic Chemistry,
Год журнала:
2022,
Номер
42(12), С. 4024 - 4024
Опубликована: Янв. 1, 2022
2H-Indazole
is
a
privileged
scaffold
widely
existing
in
drugs
and
bioactive
molecules.The
C-H
functionalization
of
2H-indazole
the
cutting
edge
medicinal
chemistry
organic
chemistry.Compared
with
traditional
synthetic
methods,
visible
light/electrochemical-promoted
method
has
mild
conditions
an
environmentally
friendly
strategy.The
2-aryl-2H-indazoles
at
C-3
position
catalyzed
by
photochemical/electrochemical
strategies
recent
years
summarized
terms
catalytic
systems,
special
emphasis
on
corresponding
reaction
mechanism,
which
might
inspire
further
development
new
methods.