Radiation-enhanced self-cascade catalytic Ti3C2Tx-based platform enables controlled release of trans-resveratrol for synergistic radiosensitization against metastasis of orthotopic breast cancer

Nano Today, Год журнала: 2023, Номер 50, С. 101836 - 101836

Опубликована: Март 28, 2023

Язык: Английский

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Strategies for engineering biomimetic materials for tumor therapy

Matter, Год журнала: 2025, Номер 8(1), С. 101899 - 101899

Опубликована: Янв. 1, 2025

Язык: Английский

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Reactive Oxygen Species Amplifier Based on Bi2WO6/BP Heterojunction for High Efficiency Radiotherapy Enhancement

Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Insufficient reactive oxygen species (ROS) generation and radioresistance resulting from the intrinsic features of tumors consistently give rise to unsatisfactory therapeutic outcomes radiotherapy (RT).

Язык: Английский

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Ultrasound-Activated Nano-Oxygen Sensitizer for Sonodynamic-Radiotherapy of Esophageal Cancer

Nanoscale Advances, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Background: owing to the intricate nature, variability, and persistent oxygen-deficient environment associated with esophageal cancer (EC) tissues, radiotherapy (RT) sometimes doesn't work as well because some cells can resist radiation a certain extent. This lead coming back in same spot or even making treatment ineffective. The integration of RT oxygenation strategies is common approach treatment. advent oxygen-enhancing sonodynamic therapy (SDT), leveraging cytotoxic effects reactive oxygen species (ROS), has garnered significant attention an innovative inducing cell death. Methods: this study utilized nanobubbles (NBs) containing acoustic sensitizer indocyanine green (ICG) create nanoplatform (ICG@O2 NBs) that incorporates oxygen-enhanced SDT RT. Besides, NBs are paired low-frequency ultrasound (LFUS), known ultrasound-targeted nano-bubble destruction (UTND), for precise drug release improved safety. Results: experimental findings, including JC-1/DCFH-DA assays, demonstrate ICG@O2 effectively enhance performance both SDT. RNA sequencing (RNA-seq) demonstrated differential expression mRNA LncRNA prior after co-treatment. KEGG GO pathway analysis were then conducted enriching recognizing target genes pathways correlated sensitivity RT, which revealed be remarkably clustered RT-associated pathways. Conclusion: vitro vivo investigations have indicated efficacy synergistic treatments, highlighting potential combining managing EC.

Язык: Английский

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Nanotechnology meets radiobiology: Fullerenols and Metallofullerenols as nano-shields in radiotherapy

Biomedicine & Pharmacotherapy, Год журнала: 2025, Номер 184, С. 117915 - 117915

Опубликована: Фев. 20, 2025

Язык: Английский

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