Catalysts,
Год журнала:
2023,
Номер
13(1), С. 143 - 143
Опубликована: Янв. 7, 2023
The
development
of
non-natural
enzymatic
catalysis
is
important
for
multicomponent
tandem
organic
transformations.
However,
the
delicate
acting
environments
biological
enzymes
still
present
some
challenges
in
synthesis
spirooxindole
skeleton
via
catalysis.
To
address
these
issues,
a
lipase-catalyzed
method
was
developed
frameworks.
Using
easily
available
isatins,
cycloketones,
and
malononitriles
as
substrates,
mild
reaction
conditions,
reasonable
time,
moderate
to
good
yields
(67–92%)
excellent
functional
group
tolerance
were
accomplished
this
protocol.
related
mechanism
explanation
also
speculated
paper.
Molecules,
Год журнала:
2022,
Номер
27(22), С. 7798 - 7798
Опубликована: Ноя. 12, 2022
Organophosphorus
compounds
are
the
core
structure
of
many
active
natural
products.
The
synthesis
these
is
generally
achieved
by
metal
catalysis
requiring
specifically
functionalized
substrates
or
harsh
conditions.
Herein,
we
disclose
phospha-Michael
addition
reaction
biphenyphosphine
oxide
with
various
substituted
β-nitrostyrenes
benzylidene
malononitriles.
This
biocatalytic
strategy
provides
a
direct
route
for
C-P
bonds
good
functional
group
compatibility
and
simple
practical
operation.
Under
optimal
conditions
(styrene
(0.5
mmol),
Novozym
435
(300
U),
EtOH
(1
mL)),
lipase
leads
to
formation
organophosphorus
in
yields
up
94%
at
room
temperature.
Furthermore,
confirm
role
catalytic
triad
this
reaction.
new
system
will
have
broad
applications
organic
synthesis.
