Molbank,
Год журнала:
2022,
Номер
2022(1), С. M1341 - M1341
Опубликована: Фев. 15, 2022
The
synthesis
and
structural
diversification
of
N-heterocycles
systems
have
attracted
much
attention
because
their
potential
applications.
Three
6-aryl-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carbaldehyde
4
derivatives,
in
reaction
with
acetophenones
5,
via
conventional
Claisen–Schmidt
condensation
reactions,
generated
the
respective
enones.
enones
were
used
as
electron-deficient
olefins
a
“formal”
[2+3]
cycloaddition
using
p-tosylmethyl
isocyanide—TosMIC
7.
This
protocol
allows
access
to
3-(substituted
aroyl)-4-heteroaryl
pyrrole
derivatives
by
Van
Leusen
method.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(7), С. 6581 - 6581
Опубликована: Апрель 1, 2023
Multicomponent
reactions
(MCRs)
have
emerged
as
a
powerful
strategy
in
synthetic
organic
chemistry
due
to
their
widespread
applications
drug
discovery
and
development.
MCRs
are
flexible
transformations
which
three
or
more
substrates
react
form
structurally
complex
products
with
high
atomic
efficiency.
They
being
increasingly
appreciated
highly
exploratory
evolutionary
tool
by
the
medicinal
community,
opening
door
sustainable,
cost-effective
rapid
synthesis
of
biologically
active
molecules.
In
recent
years,
MCR-based
strategies
found
extensive
application
field
discovery,
several
anticancer
drugs
been
synthesized
through
MCRs.
this
review,
we
present
an
overview
representative
literature
examples
documenting
different
approaches
development
new
drugs.
An
overview
of
pyrroles
as
distinct
scaffolds
with
therapeutic
potential
and
the
significance
pyrrole
derivatives
for
drug
development
are
provided
in
this
article.
It
lists
instances
naturally
occurring
pyrrole-containing
compounds
describes
sources
nature,
including
plants
microbes.
also
explains
many
conventional
modern
synthetic
methods
used
to
produce
pyrroles.
The
key
topics
biological
characteristics,
pharmacological
behavior,
functional
alterations
displayed
by
derivatives.
details
how
treat
infectious
diseases.
disorders
resistant
standard
treatments
discusses
function
containing
combating
Furthermore,
review
covers
uses
treating
non-infectious
diseases
resistance
mechanisms
illnesses
like
cancer,
diabetes,
Alzheimer's
Parkinson's
important
discoveries
probable
avenues
research
finally
summarized,
along
their
medicinal
chemists
development.
A
reference
from
last
two
decades
is
included
review.
ACS Sustainable Chemistry & Engineering,
Год журнала:
2022,
Номер
10(25), С. 8115 - 8134
Опубликована: Май 26, 2022
The
impressive
success
in
the
synthesis
of
novel
products
via
sustainable
and
green
methods
is
a
crucial
purpose
organic
synthesis.
Water
as
"green
solvent"
plays
vital
role
accelerating
some
reactions,
displaying
unique
reactivity
selectivity
from
conventional
solvents.
isocyanide-based
multicomponent
reactions
(I-MCRs)
versatile
have
received
significant
consideration
pseudopeptidic
frames,
especially
drug
discovery.
This
because
nature
isocyanides
that
play
special
active
reactant.
I-MCRs
water
solvent
reagent
for
compounds
become
an
interesting
research
direction,
enabling
simultaneous
growth
both
solvents
toward
ideal
reaction
rate
was
accelerated
due
to
lower
activation
volumes
condensation
several
reactants
into
single
reactive
intermediate
product.
Furthermore,
executed
possibly
are
mild,
easily
controlled,
environmentally
friendly,
which
conform
well
"Green
Chemistry"
principles.
On
other
hand,
these
powerful
syntheses
aqueous
media
perpetuated
by
acceleration
reduction
number
workups,
purification,
extraction
steps.
main
subject
this
review
performed
pseudopeptide
structures.
It
deserves
be
pointed
out
whereas
progress
has
been
recently
made
on
MCRs
transformations,
there
no
exclusive
account
focus
publish
about
eco-friendly
pseudopeptides.
Nevertheless,
we
hope
themed
assemblage
will
attractive
useful
pharmaceutical
chemists
encourage
more
development
fascinating
engaging
field.
The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
88(3), С. 1533 - 1544
Опубликована: Янв. 19, 2023
A
four-component
synthesis
of
tetrasubstituted
pyrroles
was
developed
under
metal-free
conditions.
The
pyrrole
ring
formed
in
one
pot
through
[2
+
1
1]
condensation
using
ammonium
salt
as
the
nitrogen
source.
In
this
strategy,
1,4-naphthoquinones
and
maleimides
were
used
versatile
C2
fragments
to
provide
substituted
benzo[f]isoindole-4,9-diones
pyrrolo[3,4-c]pyrrole-1,3-diones,
respectively.
This
work
is
highlighted
by
source,
readily
available
starting
materials
multibond
formation
(two
C–C
two
C–N
bonds)
a
single
operation.
Asian Journal of Organic Chemistry,
Год журнала:
2023,
Номер
12(9)
Опубликована: Июль 29, 2023
Abstract
Multicomponent
reactions
(MCRs)
have
emerged
as
powerful
tools
in
synthetic
chemistry
for
the
efficient
synthesis
of
diverse
molecular
scaffolds,
particularly
nitrogen‐containing
heterocycles.
Despite
their
numerous
advantages,
use
transition
metal
catalysts
or
additives
MCRs
can
present
limitations
due
to
cost,
toxicity,
and
environmental
concerns.
In
recent
years,
there
has
been
a
growing
interest
metal‐free
N
‐heterocyclic
compounds.
This
review
provides
comprehensive
concise
overview
advancements
valuable
‐heterocycles
over
past
five
years.
The
is
systematically
organized,
categorizing
discussed
based
on
size
heterocyclic
ring
number
nitrogen
atoms.
Only
that
result
formation
rings
containing
at
least
one
atom
are
included,
while
derivatization
using
falls
outside
scope
this
review.
By
highlighting
developments
field,
aims
showcase
potential
significance
sustainable
strategies
accessing
elimination
metals
not
only
simplifies
reaction
conditions
but
also
contributes
greener
more
environmentally
friendly
approaches.
serves
resource
researchers
interested
design
application
