Marine Actinomycetes Associated with Stony Corals: A Potential Hotspot for Specialized Metabolites

Microorganisms, Год журнала: 2022, Номер 10(7), С. 1349 - 1349

Опубликована: Июль 4, 2022

Microbial secondary metabolites are an important source of antibiotics currently available for combating drug-resistant pathogens. These produced by various microorganisms, including Actinobacteria. Actinobacteria have a colossal genome with wide array genes that code several bioactive and enzymes. Numerous studies reported the isolation screening millions strains actinomycetes from habitats specialized worldwide. Looking at extent importance in fields, corals highlighted as potential hotspot untapped new metabolites. Unfortunately, knowledge about diversity, distribution biochemistry marine compared to hard is limited. In this review, we aim summarize recent on isolation, discovery natural compounds associated corals. A total 11 species actinomycetes, representing nine different families were recovered during period 2007 2022. addition, study examined 13 five genera 2017 2022 antibacterial, antifungal cytotoxic activities. Coral-derived mechanisms action against their competitors.

Язык: Английский

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Marine life as a source of anti-prostate cancer agents: an updated overview (2003–2023)

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 20, 2025

Язык: Английский

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Marine indole alkaloid diversity and bioactivity. What do we know and what are we missing?

Natural Product Reports, Год журнала: 2023, Номер 40(10), С. 1595 - 1607

Опубликована: Янв. 1, 2023

Limited screening focus has led to most marine derived indole alkaloids (MIA) being inactive. However, computational comparisons with drugs suggest MIAs will be active in new disease relevant targets if a shift is adopted.

Язык: Английский

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Exploring Diverse Bioactive Secondary Metabolites from Marine Microorganisms Using Co-Culture Strategy

Molecules, Год журнала: 2023, Номер 28(17), С. 6371 - 6371

Опубликована: Авг. 31, 2023

The isolation and identification of an increasing number secondary metabolites featuring unique skeletons possessing diverse bioactivities sourced from marine microorganisms have garnered the interest numerous natural product chemists. There has been a growing emphasis on how to cultivate enhance chemical diversity avoid rediscovery known ones. Given significance as means communication among microorganisms, microbial co-culture introduced. By mimicking growth patterns communities in their habitats, strategy is anticipated stimulate biosynthetic gene clusters that remain dormant under traditional laboratory culture conditions, thereby inducing production novel metabolites. Different previous reviews mainly focusing fermentation conditions or metabolite diversities marine-derived co-paired strains, this review covers 2012 2022, turns particular discussion highlighting selection strains for especially methods co-cultural apparatus, screening approaches convenient rapid detection metabolites, these are important co-culture. Finally, structural bioactivity molecules also discussed. challenges prospects discussed behave views authors.

Язык: Английский

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β-Lactams from the Ocean

Marine Drugs, Год журнала: 2023, Номер 21(2), С. 86 - 86

Опубликована: Янв. 25, 2023

The title of this essay is as much a question it statement. discovery the β-lactam antibiotics—including penicillins, cephalosporins, and carbapenems—as largely (if not exclusively) secondary metabolites terrestrial fungi bacteria, transformed modern medicine. antibiotic β-lactams inactivate essential enzymes bacterial cell-wall biosynthesis. Moreover, ability to function enzyme inhibitors such great medical value, that which degrade hydrolytically β-lactams, β-lactamases, have equal value. Given privileged status for ring, therefore disappointment exemplification ring in marine sparse. It may be biologically active are there, simply yet encountered. In report, we posit second explanation: value secure an ecological advantage environment might compromised by its close structural similarity β-lactones quorum sensing. steric reactivity similarities between represent outside-of-the-box opportunity correlating new structures targets compelling biological activities.

Язык: Английский

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In Silico Screening of Bacteriocin Gene Clusters within a Set of Marine Bacillota Genomes

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(5), С. 2566 - 2566

Опубликована: Фев. 22, 2024

Due to their potential application as an alternative antibiotics, bacteriocins, which are ribosomally synthesized antimicrobial peptides produced by bacteria, have received much attention in recent years. To identify bacteriocins within marine most of the studies employed a culture-based method, is more time-consuming than silico approach. For that, aim this study was bacteriocin gene clusters and producers 51 Bacillota (formerly Firmicutes) genomes, using BAGEL4, genome mining tool. As result, we found out that majority selected (60.78%) producers, identified 77 clusters, belong class I known RiPPs (ribosomally post-translationally modified peptides). The putative attractive target for further vitro research, such production heterologous expression system.

Язык: Английский

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Bioactive Compounds from Terrestrial and Marine-Derived Fungi of the Genus Neosartorya †

Molecules, Год журнала: 2022, Номер 27(7), С. 2351 - 2351

Опубликована: Апрель 6, 2022

Fungi comprise the second most species-rich organism group after that of insects. Recent estimates hypothesized currently reported fungal species range from 3.5 to 5.1 million types worldwide. can grow in a wide habitats, desert depths sea. Most develop terrestrial environments, but several live only aquatic and some symbiotic relationships with plants, animals, or other fungi. have been proved be rich source biologically active natural products, which are clinically important drugs such as β-lactam antibiotics, penicillin cephalosporin, immunosuppressant, cyclosporine, cholesterol-lowering drugs, compactin lovastatin. Given biodiversity, it is easy perceive small fraction fungi worldwide ever investigated regarding production valuable compounds. Traditionally, classified primarily based on structures associated sexual reproduction. Thus, genus Neosartorya (Family Trichocomaceae) telemorphic (sexual state) Aspergillus section known Fumigati, produces both state ascospores an asexual conidiospores, while conidiospores. However, according Melbourne Code nomenclature, name used for states. Consequently, was no longer 1 January 2013. Nevertheless, still had already taxonomically before new rule force. Another aspect despite number (23 species) Neosartorya, although less than half them chemically, chemical diversity this impressive. Many classes compounds, unique scaffolds, indole alkaloids, peptides, meroterpenes, polyketides, its terrestrial, marine-derived, endophytic species. Though biological pharmacological activities isolated metabolites due available assay systems, they exhibited relevant activities, anticancer, antibacterial, antiplasmodial, lipid-lowering, enzyme-inhibitory activities.

Язык: Английский

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Mini-review on the antimicrobial potential of actinobacteria associated with seagrasses

Опубликована: Фев. 29, 2024

The search for novel therapeutic agents to combat the crisis of antimicrobial resistance has spanned from terrestrial unique, marine environments. Currently, most drugs available usage are derived microbial metabolites, especially those belonging bacterial group, actinobacteria. Actinobacteria hotspot organisms that exist in all habitats with a myriad unique biosynthetic metabolites. Seagrasses appear be key ecosystem within coastal environment worth bioprospecting natural products. Unfortunately, literature about bioactive potential their associated prokaryotes, including actinobacteria remains limited. In this context, review focused on antibiotic-producing capabilities different parts seagrass plants (i.e. roots, rhizomes, and leaves). To date, there were no purified molecules seagrass-associated subjected structure elucidation. From underpinning numerous biological profiles such as antibacterial, antifungal, algicidal activities seagrass-derived reported during period 2012–2020, it provides continual growth knowledge accruing overtime, providing foundation future research.

Язык: Английский

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Acremocholone, an Anti‐Vibrio Steroid from the Marine Mesophotic Zone Ciocalypta Sponge‐Associated Fungus Acremonium sp. NBUF150

Chemistry & Biodiversity, Год журнала: 2022, Номер 19(4)

Опубликована: Фев. 23, 2022

Mesophotic coral ecosystems (MCEs) represent an underexplored source of intriguing natural products. Efforts to discover bioactive metabolites from sponge-associated fungi in MCEs identified a new steroid, acremocholone (1) and its three known analogs (2-4), Acremonium sp. NBUF150. The NBUF150 was isolated Ciocalypta sponge located 70 m deep within the South China Sea. planar structures absolute configuration 1-4 were determined NMR-derived spectroscopic data, HR-ESI-MS, X-ray crystallography. Compound 1 exhibited antimicrobial inhibition against Vibrio scophthalmi, V. shilonii brasiliensis at minimum inhibitory concentrations 8 μg/mL; compound 2 inhibited 32 μg/mL, respectively, 4 growth 16 μg/mL. Sponge associated promising resource anti-Vibrio drug leads for aquaculture use.

Язык: Английский

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A marine lipopeptides-producing Bacillus amyloliquefaciens HY2-1 with a broad-spectrum antifungal and antibacterial activity and its fermentation kinetics study

World Journal of Microbiology and Biotechnology, Год журнала: 2023, Номер 39(8)

Опубликована: Май 15, 2023

Язык: Английский

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