Chemistry - A European Journal,
Год журнала:
2021,
Номер
27(54), С. 13613 - 13623
Опубликована: Июль 20, 2021
A
catalytic
domino
reduction-imine
formation-intramolecular
cyclization-oxidation
for
the
general
synthesis
of
a
wide
variety
biologically
relevant
N-polyheterocycles,
such
as
quinoxaline-
and
quinoline-fused
derivatives,
phenanthridines,
is
reported.
simple,
easily
available,
environmentally
friendly
dioxomolybdenum(VI)
complex
has
proven
to
be
highly
efficient
versatile
catalyst
transforming
broad
range
starting
nitroarenes
involving
several
redox
processes.
Not
only
this
sustainable,
step-economical
well
air-
moisture-tolerant
method,
but
also
it
worth
highlighting
that
waste
byproduct
generated
in
first
step
sequence
recycled
incorporated
final
target
molecule,
improving
overall
synthetic
efficiency.
Moreover,
selected
indoloquinoxalines
have
been
photophysically
characterized
cyclohexane
toluene
with
exceptional
fluorescence
quantum
yields
above
0.7
alkyl
derivatives.
A
new
catalytic
conversion
type
of
nitro
substrate
with
CO2
as
a
single-carbon
source
is
presented,
wherein
great
collection
azaheterocycles
generated
by
newly
established
iridium-catalyzed,
copper-induced
reductive
system.
This
procedure
handily
employs
poly(methylhydrosiloxane)
(PMHS)
the
reductant
to
simultaneously
realize
dual
reduction
highest
oxidation-state
and
units
in
one
operation.
Elaborate
mechanistic
studies
illustrate
essential
role
iridium
catalyst
reducing
NO2
moiety
well
double
functions
copper
additive
subsequent
formylation
C-H
cyclization
steps.
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 3, 2025
A
divergent
[5
+
1]
cyclization
reaction
of
o-aminobenzamides
with
vinylene
carbonate
has
been
developed,
rapidly
generating
three
types
cyclic
molecules
including
quinazolinones,
2-methylquinazolinones,
and
2,3-dihydroquinazolinones
high
chemoselectivity.
In
this
discovery,
blooms
as
a
multifunctional
reagent
to
participate
in
cyclization.
The
potential
new
finding
is
further
emphasized
by
assembling
the
benzothiazole
heteroarene
via
[4
version
tolerating
bioactive
units
well.
Organic & Biomolecular Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
We
have
developed
a
visible-light-driven
photocatalytic
tandem
reaction
system
to
achieve
the
efficient
synthesis
of
2-sulfenylated
pyrrolo[1,2-α]quinoxalines
based
on
radical
addition-cyclization
mechanism.
Mechanistic
studies
show
that
sulfur
intermediates
generated
in
directly
participate
subsequent
formation
C-S
bonds.
This
strategy
has
opened
up
an
synthetic
pathway
for
precise
C2-sulfur-substituted
heterocyclic
compounds.
Chemistry - A European Journal,
Год журнала:
2021,
Номер
27(54), С. 13613 - 13623
Опубликована: Июль 20, 2021
A
catalytic
domino
reduction-imine
formation-intramolecular
cyclization-oxidation
for
the
general
synthesis
of
a
wide
variety
biologically
relevant
N-polyheterocycles,
such
as
quinoxaline-
and
quinoline-fused
derivatives,
phenanthridines,
is
reported.
simple,
easily
available,
environmentally
friendly
dioxomolybdenum(VI)
complex
has
proven
to
be
highly
efficient
versatile
catalyst
transforming
broad
range
starting
nitroarenes
involving
several
redox
processes.
Not
only
this
sustainable,
step-economical
well
air-
moisture-tolerant
method,
but
also
it
worth
highlighting
that
waste
byproduct
generated
in
first
step
sequence
recycled
incorporated
final
target
molecule,
improving
overall
synthetic
efficiency.
Moreover,
selected
indoloquinoxalines
have
been
photophysically
characterized
cyclohexane
toluene
with
exceptional
fluorescence
quantum
yields
above
0.7
alkyl
derivatives.
