Regenerative Biomaterials,
Год журнала:
2023,
Номер
10
Опубликована: Янв. 1, 2023
Abstract
Nanoparticles
(NPs)
hold
tremendous
targeting
potential
in
cardiovascular
disease
and
regenerative
medicine,
exciting
clinical
applications
are
coming
into
light.
Vascular
endothelial
cells
(ECs)
exposure
to
different
magnitudes
patterns
of
shear
stress
(SS)
generated
by
blood
flow
could
engulf
NPs
the
blood.
However,
an
unclear
understanding
role
SS
on
NP
uptake
is
hindering
progress
improving
therapies.
Here,
temporal
spatial
distribution
vascular
ECs
effect
highlighted.
The
mechanism
affecting
through
regulating
cellular
ROS
level,
glycocalyx
membrane
fluidity
summarized,
molecules
containing
clathrin
caveolin
engulfment
process
elucidated.
expected
overcome
current
bottlenecks
change
field
nanomedicine.
This
assessment
how
affects
cell
marginalization
vessels
guide
future
research
biology
drugs.
Molecules,
Год журнала:
2024,
Номер
29(15), С. 3546 - 3546
Опубликована: Июль 27, 2024
The
development
of
targeted
drug
delivery
systems
has
been
a
pivotal
area
in
nanomedicine,
addressing
challenges
like
low
loading
capacity,
uncontrolled
release,
and
systemic
toxicity.
This
study
aims
to
develop
evaluate
dual-functionalized
mesoporous
silica
nanoparticles
(MSN)
for
celecoxib,
enhancing
loading,
achieving
controlled
reducing
toxicity
through
amine
grafting
imidazolyl
polyethyleneimine
(PEI)
gatekeepers.
MSN
were
synthesized
using
the
sol-gel
method
functionalized
with
(3-aminopropyl)
triethoxysilane
(APTES)
create
amine-grafted
(MSN-NH
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Авг. 3, 2024
Cerium
oxide
nanoparticles
are
known
for
their
antibacterial
effects
resulting
from
Ce3+
to
Ce4+
conversion.
Application
of
such
cerium
in
dentistry
has
been
previously
considered
but
limited
due
deterioration
mechanical
properties.
Hence,
this
study
aimed
examine
mesoporous
silica
(MCM-41)
coated
with
and
evaluate
the
properties
when
applied
dental
composite
resin.
were
on
MCM-41
surface
using
sol-gel
method
by
adding
nanoparticle
precursor
dispersion.
The
samples
tested
activity
against
Streptococcus
mutans
via
CFU
MTT
assays.
assessed
flexural
strength
depth
cure
according
ISO
4049.
Data
analyzed
a
t-test,
one-way
ANOVA,
Tukey's
post-hoc
test
(p
=
0.05).
experimental
group
showed
significantly
increased
compared
control
groups
<
0.005).
exhibited
decreasing
trend
as
amount
nanoparticle-coated
increased.
However,
values
silane
met
4049
standard.
Antibacterial
increasing
amounts
nanoparticles.
Although
decreased,
treatment
overcame
drawback.
may
be
used
resin
composite.
Regenerative Biomaterials,
Год журнала:
2023,
Номер
10
Опубликована: Янв. 1, 2023
Abstract
Nanoparticles
(NPs)
hold
tremendous
targeting
potential
in
cardiovascular
disease
and
regenerative
medicine,
exciting
clinical
applications
are
coming
into
light.
Vascular
endothelial
cells
(ECs)
exposure
to
different
magnitudes
patterns
of
shear
stress
(SS)
generated
by
blood
flow
could
engulf
NPs
the
blood.
However,
an
unclear
understanding
role
SS
on
NP
uptake
is
hindering
progress
improving
therapies.
Here,
temporal
spatial
distribution
vascular
ECs
effect
highlighted.
The
mechanism
affecting
through
regulating
cellular
ROS
level,
glycocalyx
membrane
fluidity
summarized,
molecules
containing
clathrin
caveolin
engulfment
process
elucidated.
expected
overcome
current
bottlenecks
change
field
nanomedicine.
This
assessment
how
affects
cell
marginalization
vessels
guide
future
research
biology
drugs.
