L‐Arginine‐Modified Selenium Nanozymes Targeting M1 Macrophages for Oral Treatment of Ulcerative Colitis

Small, Год журнала: 2025, Номер unknown

Опубликована: Янв. 6, 2025

Ulcerative colitis (UC) involves persistent inflammation in the colon and rectum, with excessive reactive oxygen species (ROS) accumulation. This ROS buildup damages colonic epithelial cells disrupts intestinal flora, worsening disease progression. Current antioxidant therapies are limited due to their instability gut lack of targeting, hindering precise intervention at lesion site. study prepares an L-Arginine-modified selenium nanozyme (Se-CA) for targeted oral treatment UC. Se-CA specifically targets M1-type macrophages sites by binding cationic amino acid transporter protein 2 on surface macrophages. In vitro studies show that scavenges nitrogen (RNS) artificial gastric fluids, inhibits iron death cells. mice model ulcerative colitis, administration is effective through its anti-inflammatory properties, inhibition regulation flora. conclusion, this work provides new insights into

Язык: Английский

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Efficient hydrogen peroxide reduction in glutathione peroxidase cycle using cost-effective FeSe2 nanospheres

Frontiers in Agronomy, Год журнала: 2025, Номер 6

Опубликована: Янв. 22, 2025

Introduction Hydrogen peroxide plays a crucial role in melanogenesis by regulating tyrosinase activity, the key melanin-forming enzyme responsible for browning of fruits, vegetables, and seafood. The need effective solutions to mitigate such processes highlights significance developing advanced catalytic agents. Methods We synthesized highly FeSe 2 nanospheres using one-step solvothermal process. were characterized through transmission electron microscopy (TEM), energy-dispersive X-ray analysis (EDX), powder diffraction (XRD). Enzymatic activity was evaluated plotting Michaelis-Menten Lineweaver-Burk graphs calculate V max K m parameters. Comparative analyses with control sample other known enzymes performed assess efficiency. Results discussion successfully catalyzed reduction hydrogen water alcohol, demonstrating enzyme-like activity. initial reaction rate 11 times higher than significantly outperformed enzymes, except those relying on expensive noble metals. These (termed Nanozymes) mimic enzymatic action natural antioxidants, as glutathione peroxidase (GPx) enzyme, biological systems. Their exceptional efficiency makes them strong candidate practical applications mitigating early caused melanogenesis. Conclusions nanozymes exhibit great promise biocatalyst enhancing shelf life fruits vegetables reducing damage due This cost-effective efficient alternative or metal-based offers significant potential food preservation industries.

Язык: Английский

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Oxidative stress products and managements in atopic dermatitis

Frontiers in Medicine, Год журнала: 2025, Номер 12

Опубликована: Май 9, 2025

Atopic dermatitis (AD) is a chronic inflammatory skin disorder that affects significant portion of the global population, severely impacting quality life and causing physical psychological distress patients. Oxidative stress, resulting from an imbalance between oxidation antioxidation activities, plays pivotal role in pathogenesis AD. Monitoring oxidative stress products can offer valuable insights into development AD highlight essential clinical therapeutic effects. Additionally, evidence suggests antioxidant strategies alleviate or avert damage induced by free radicals promise treatment In addition to directly utilizing natural nanomaterials for interventions, these also be incorporated hydrogels, which help repair barrier support sustained release agents. Furthermore, microneedles provide minimally invasive method delivering antioxidants deeper layers skin, enhancing efficacy. This review aims summarize AD, focusing main (DNA, protein, lipid products), as well approaches involving products, nanomaterials, microneedles. Understanding biomarkers therapy provides important management

Язык: Английский

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An oxidized chondroitin sulfate-crosslinked and CuCDs-loaded decellularized bovine pericardium with improved anti-coagulation, pro-endothelialization and anti-calcification properties for BHVs

Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

The multifunctionality of CuCDs–OCS–BP with anti-coagulation, anti-calcification and anti-inflammatory properties a strong ability to promote endothelial proliferation is presented.

Язык: Английский

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A comprehensive exploration of the latest innovations for advancements in enhancing selectivity of nanozymes for theranostic nanoplatforms

Nanoscale, Год журнала: 2023, Номер 15(39), С. 15885 - 15905

Опубликована: Янв. 1, 2023

This work explores cutting-edge strategies to enhance nanozyme selectivity, vital for improving diagnostics and treatments, unlocking their full theranostic potential.

Язык: Английский

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