Current Organic Chemistry,
Год журнала:
2023,
Номер
27(1), С. 62 - 70
Опубликована: Янв. 1, 2023
Aims:
In
this
study,
the
synthesis
and
biological
activity
of
new
1,3,4-oxadiazole
derivatives
will
be
discussed.
Background:
Microbial
contagion
via
different
bacterial
strains
discomposes
healthcare
system
globally.
2019
E.
coli,
S.
aureus,
K.
pneumoniae,
pneumoniae
were
reported
as
most
bacteremia
deaths
causes.
Over
time,
bacteria
develop
ways
to
overcome
antibiotic
activity,
causing
multidrug
resistant
(MDR).
The
MDR
is
considered
one
biggest
concerns
scientists
worldwide
due
its
direct
effect
on
patients'
lives.
As
a
result,
developing
drugs
has
become
imperative
for
protect
human
life.
Objective:
Developing
water
soluble
antibacterial
from
cheap
commercially
available
materials.
Methods:
Microdilution
Assay
Antimicrobial
potential
was
performed
based
experimental
procedure
with
slight
modifications.
Briefly,
chemical
preparations
serially
diluted
(2-fold)
ten
times
Muller
Hinton
broth.
Well
number
eleven
negative
control
growth,
while
well
twelve
contained
nutrient
broth
only
used
positive
growth.
achieved
concentrations
solutions
10
mg/mL
9
μg/mL.
A
serial
two-fold
dilution
DMSO
prepared
ensure
that
antimicrobial
not
DMSO.
Moreover,
blank
or
background
each
final
concentration
in
(except
control)
adjusted
0.75
×
106
CFU/ml.
After
inoculation
bacteria,
plates
covered
incubated
overnight
at
37oC
24
hours.
then
scanned
an
enzyme-linked
immunosorbent
assay
(ELISA)
reader
600
Nano
moles
examine
density.
lowest
did
allow
any
visible
microbial
growth
test
minimal
inhibitory
(MIC),
which
further
confirmed
by
culturing
(MIC)
Henton
agar
incubating
twenty-four
molecular
geometries
compounds
4a,
4e,
4j,
4p
optimized
B3LYP/6-311+G(d,p)
level
theory
using
DFT
calculations.
Results:
examination
results
show
compound
4j
interesting
against
faecium
MIC
value
However,
it
found
have
low
E.coli
625
On
other
hand,
4e
showed
very
good
78
μg/mL
312
structural
properties
investigated
density
functional
(DFT)
biologically
active
gas
phase
B3LYP
method
6-31+G(d,p)
bases
set.
resulting
ground-state
structures
take
V
shape
two
conjugated
are
connected
methylene
group.
electrostatic
map
(MEP)
calculated
indicate
that,
intense
blue
region
largest
distributed
over
pyridinium
ring,
indicates
binding
chloride
ion.
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 21, 2025
Substrate
and
reagent-controlled
dimerization
of
vinyl
para-quinone
methides
(VPQMs)
is
reported.
When
subjected
to
Brønsted
acidic
conditions,
VPQM
occurs
via
a
formal
1,8-addition
provide
griffipavixanthone
(GPX)-type
congeners.
Under
optimized
Lewis
change
in
regioselectivity
affords
limonene-containing
dimers
by
1,6-addition/cyclization
process.
This
divergent
reactivity
has
been
explored
on
several
substrates
differing
complexity,
providing
access
analogues
the
natural
product
(GPX)
as
well
range
novel,
substituted
limonene
dimers.
Molecules,
Год журнала:
2023,
Номер
28(5), С. 2056 - 2056
Опубликована: Фев. 22, 2023
In
recent
years,
donor-acceptor
(D-A)-type
conjugated
polymers
have
been
widely
used
in
the
field
of
organic
solar
cells
(OSCs)
and
electrochromism
(EC).
Considering
poor
solubility
D-A
polymers,
solvents
material
processing
related
device
preparation
are
mostly
toxic
halogenated
solvents,
which
become
biggest
obstacle
to
future
commercial
process
OSC
EC
field.
Herein,
we
designed
synthesized
three
novel
PBDT1-DTBF,
PBDT2-DTBF,
PBDT3-DTBF,
by
introducing
polar
oligo
(ethylene
glycol)
(OEG)
side
chains
different
lengths
donor
unit
benzodithiophene
(BDT)
as
chain
modification.
Studies
on
solubility,
optics,
electrochemical,
photovoltaic
electrochromic
properties
conducted,
influence
introduction
OEG
its
basic
is
also
discussed.
show
unusual
trends
that
need
further
research.
However,
since
PBDT-DTBF-class
acceptor
IT-4F
failed
form
proper
morphology
under
low-boiling
point
solvent
THF
processing,
performance
prepared
devices
not
ideal.
films
with
showed
relatively
desirable
cast
from
display
higher
CE
than
CB
solvent.
Therefore,
this
class
has
application
feasibility
for
green
fields.
The
research
provides
an
idea
design
solvent-processable
polymer
cell
materials
a
meaningful
exploration
electrochromism.
Current Organic Chemistry,
Год журнала:
2023,
Номер
27(3), С. 190 - 205
Опубликована: Фев. 1, 2023
Abstract:
The
synthesis
of
organofluorine
compounds
plays
a
vital
role
in
the
field
pharmaceuticals,
agrochemicals,
and
materials
since
fluorine-containing
have
shown
improved
biological
physicochemical
properties.
Significant
research
has
been
directed
towards
synthesizing
because
displayed
several
activities,
including
anticancer,
antitumor,
antihypertensive,
antidepressant,
anti-HIV
treatment
stroke.
Due
to
pharmaceutical
applications
compounds,
numerous
conventional
as
well
green
synthetic
methodologies
developed
for
compounds.
However,
particularly,
using
approaches
continuously
attracting
interest
advantages,
use
inexpensive
nontoxic
reagents,
catalytic,
highly
efficient,
short
reaction
time,
energy
high
yields,
environmentally
benign
over
methods.
Among
tools,
microwave-assisted
synthesis,
water,
ionic
liquids
solvent/reaction
media,
organocatalysts,
photocatalysts,
solvent-free
catalyst-free
conditions
exploited
past
decades
In
this
review,
we
highlighted
recent
developments
various
methods
via
electrophilic
fluorination
fluorohydrins,
fluorinated
acyclic
&
cyclic
β
-ketoesters,
1,3-dicarbonyl
ketones,
α
-
cyanoesters,
α-aryl-tetralones,
α-amino
acids,
flavanones,
heterocycles
such
pyridine,
pyrimidine,
pyrrole,
pyrazolone,
benzofuran,
indole,
flavanone,
coumarin
derivatives.
addition,
some
biologically
active
HIV-1
integrase
inhibitors,
20-deoxy-20-fluorocamptothecin,
estrone,
sclareolide,
BMS-
204352
(MaxiPost),
naproxen
fluoxetine.
Current Organic Chemistry,
Год журнала:
2023,
Номер
27(4), С. 308 - 351
Опубликована: Фев. 1, 2023
Abstract:
Aurones,
a
member
of
the
flavonoid
family,
have
limited
occurrence
in
nature
and
are
relatively
less
explored
than
other
flavonoids
but
still
constitute
gleaming
class
therapeutically
significant
oxygen
heterocyclic
molecules
with
broad-spectrum
biological
activities.
These
secondary
plant
metabolites
responsible
for
glaring
pigmentation
to
various
colored
parts
plants.
This
review
covers
comprehensive
history
aurones
from
1918
2020.
provides
generalized
systematic
study
protocols
adopted
synthesizing
aurone
derivatives
their
profile.
Though
there
many
articles
on
activities
aurones,
none
these
cover
synthetic
aspects
thoroughly.
With
growing
number
biologically
active
natural
synthesized
massive
breakthrough
research
has
emerged,
it
is
now
one
most
researched
O-heterocycles.
The
present
aims
highlight
work
researchers
help
chemists
future
generations
design
develop
new
aurone-based
systems
therapeutic
potential.
will
also
catch
attention
exploring
potentials
aurones.
Molecules,
Год журнала:
2023,
Номер
28(21), С. 7318 - 7318
Опубликована: Окт. 28, 2023
Coordination
polymers
(CPs)
are
an
assorted
class
of
coordination
complexes
that
gaining
attention
for
the
safe
and
sustainable
removal
organic
dyes
from
wastewater
discharge
by
either
adsorption
or
photocatalytic
degradation.
Herein,
three
different
with
compositions
[Ni(HL)(H2O)2·1.9H2O]
(1),
[Mn3(HL)(L)(μ3-OH)(H2O)(phen)2·2H2O]
(2),
[Cd(HL)4(H2O)]·H2O
(3)
(H3L
=
2-(3,5-dicarboxyphenyl)-6-carboxybenzimidazole;
phen
1,10-phenanthroline)
have
been
synthesized
characterized
spectroscopically
single
crystal
X-ray
diffraction.
Single
diffraction
results
indicated
1
forms
a
2D
layer-like
framework,
while
2
exhibits
3-connected
net
Schläfli
symbol
(44.6),
3
displays
3D
supramolecular
network
in
which
two
adjacent
layers
held
π···π
interactions.
All
compounds
used
as
photocatalysts
to
catalyze
photodegradation
antibiotic
dinitrozole
(DTZ)
rhodamine
B
(RhB).
The
suggested
Mn-based
CP
exhibited
better
photodecomposition
DTZ
(91.1%)
RhB
(95.0%)
than
other
CPs
time
span
45
min.
observed
mechanisms
addressed
using
Hirshfeld
surface
analyses.
