Ultrastable and Redispersible Zwitterionic Bottlebrush Micelles for Drug Delivery

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер unknown

Опубликована: Окт. 6, 2024

Bottlebrush copolymers are increasingly used for drug delivery and biological imaging applications in part due to the enhanced thermodynamic stability of their self-assemblies. Herein, we discuss effect hydrophilic block chemistry on bottlebrush micelles. Amphiphilic bottlebrushes with zwitterionic poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) nonionic polyethylene glycol (PEG) blocks were synthesized by "grafting from" polymerization self-assembled into well-defined spherical Colloidal against disassembly challenged under high concentrations NaCl, MgSO

Язык: Английский

---

Synthesis of Dendronized Polymers via a “m+n” Grafting‐onto Strategy with Reaction‐Enhanced Reactivity of Intermediates (RERI) Mechanism

Chinese Journal of Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 18, 2025

Comprehensive Summary Dendronized polymers (DenPols) with tunable shape and surface property have been recognized as a type of promising unimolecular nanomaterials. However, it still has lacked rapid efficient approach to the facile synthesis DenPols high‐generation well‐defined structures. Herein, we report “ m+n” grafting‐onto strategy combined copper‐catalyzed azide‐alkyne cycloaddition (CuAAC) reaction reaction‐enhanced reactivity intermediates (RERI) mechanism for synthesizing G m + n by attaching ‐generation dendrons (G ) onto . In this m+n ” strategy, ( = 1, 2) bearing 1,3‐triazido branches on repeating unit were capable RERI effect that guaranteed CuAAC in an extremely way ultrafast kinetics synthesize third‐, fourth‐ fifth‐generation 1+2 , 1+3 1+4 2+2 2+3 near quantitative grafting density narrow distribution. Moreover, these resultant had more terminal groups per due three structure, exhibiting valuable potential opportunities molecular engineering. The development not only presents new avenue preparing but also holds great promise materials functional groups.

Язык: Английский

---

Helical Polymer‐Containing Bottlebrush Polymers (BBPs): Design, Synthesis, and Perspectives

Macromolecular Rapid Communications, Год журнала: 2025, Номер unknown

Опубликована: Фев. 6, 2025

Abstract Helical polymer‐containing bottlebrush polymers (BBPs) are a special and fascinating type of polymer. They possess topology contain helical as main chains (MCs) or side (SCs), thereby presenting interesting fantastic properties, such chiral amplification, circularly polarized luminescence, photonic crystal, so on. This review mainly focuses on BBPs containing polypeptides, polyacetylenes (PAs), polyisocyanides (PIs). Detailed summarizations severally given to with polypeptides MCs SCs. Meanwhile, comprising PAs fully discussed. What's more, consisted PIs SCs described separately. In addition, other briefly introduced, too. The authors hope this will motivate more interest in developing complex topologies encourage further progress functional materials.

Язык: Английский

---

pH-Responsive Shape-Changing Molecular Bottlebrush Emulsifier

Macromolecules, Год журнала: 2025, Номер unknown

Опубликована: Фев. 12, 2025

Язык: Английский

---

Supramolecular Polymer Bottlebrushes: In Situ Assessment of Noncovalent Assemblies in Human Serum by Analytical Ultracentrifugation

Macromolecular Rapid Communications, Год журнала: 2025, Номер unknown

Опубликована: Фев. 27, 2025

Abstract For nanomedical targeting and drug delivery purposes, the noncovalent assembly of polymer building blocks into defined nanostructures is an intense area research. One key assets desirable to know for potential nanocarrier stability under conditions close those in application scenarios. Here, a series based on poly(ethylene glycol) (PEG), which comprise functional end group facilitating self‐assembly supramolecular bottlebrushes (SPBs), hydrodynamically studied. The blocks, consequently assemblies, are labeled with cyanine5 (Cy5) dye enabling selective tracing materials human serum (HS) analytical ultracentrifugation (AUC) experiments. Our experiments reveal long‐term assemblies over one month storage HS at body temperature. At same time, interaction some Cy5 moieties transport protein albumin (HSA) evidenced.

Язык: Английский

---

Molecular Structure of Foldable Bottlebrush Polymers in Melts

Macromolecules, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

A bottlebrush polymer consists of a long linear backbone densely grafted with many relatively short side chains. widely accepted view is that strong steric repulsion among the highly overlapped chains prestrains backbone, resulting in low extensibility. However, we recently discovered melt polymers incompatible and collapses to reduce interfacial free energy, regardless Despite this discovery, molecular structure these so-called "foldable" their assemblies remains poorly understood. Here, present deterministic relationships architecture, mesoscopic conformation, macroscopic properties foldable polymers. combination scaling theory experiments reveals as chain grafting density decreases, diameter increases, whereas end-to-end distance decreases. These behaviors contradict existing understanding polymers, which assumes are compatible. Since store lengths can be released upon large deformations, they offer way decouple intrinsic stiffness-extensibility trade-off single-network elastomers. findings provide foundational insights into using building blocks for designing soft (bio)materials.

Язык: Английский

---

Design and synthesis of amphiphilic statistical copolymers forming unimeric micelles with thermoresponsive behaviour in the physiological range

Polymer Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

A crucial aspect of drug development is designing carriers that efficiently solubilise therapeutic agents while ensuring stability, minimising cytotoxicity, and enabling targeted delivery.

Язык: Английский

---

Polypept(o)ide‐Based Core–Shell Bottlebrush Polymers: A Versatile Platform for Drug Encapsulation

Macromolecular Bioscience, Год журнала: 2025, Номер unknown

Опубликована: Апрель 22, 2025

Abstract Cylindrical bottlebrush polymers (CBPs) enable the precise adjustment of nanoparticle properties such as size, shape, and functionality exclusively by polymer synthesis. In addition, block copolymer side chains direct access to core–shell structure. this study, synthesis polypept(o)ides‐based CBPs is presented through a “grafting‐from” strategy. While, poly‐lysine (pLys) serves backbone, poly(γ‐benzyl‐ l ‐glutamic acid)‐block‐polysarcosine (pGlu(OBn)‐ b ‐pSar) copolymers form chains. This approach enables nanoparticles, referred brushes (CSBs), with hydrodynamic radius ( R h ) from 17 70 nm, molecular weights (1320–4000 kg mol −1 dispersity indices ≈1.3 determined size‐exclusion chromatography. Dasatinib chosen drug molecule model explore potential synthetical CSBs platform for encapsulation π – ‐interactions. An overall loading efficiency 10% achieved, which also displayed sustained release within 72 h, cellular uptake into human glioblastoma (U‐87 MG) cells, drug‐related therapeutic efficacy. While can be further optimized covalent attachment, these results establish strong foundation use in nanomedicine.

Язык: Английский

---

Ammonium-Containing Methacrylic Polymer Brushes with Adjustable Hydrophilicity: Synthesis and Properties in Aqueous Solutions

Polymers, Год журнала: 2025, Номер 17(9), С. 1200 - 1200

Опубликована: Апрель 27, 2025

Reversible addition-fragmentation chain-transfer (RAFT) polymerization was used to synthesize novel thermoresponsive cationic molecular brushes with high yields-namely of copolymers methoxyoligo(ethylene glycol) methacrylate, alkoxyoligo(ethylene and N-methacryloylaminopropyl-N,N-dimethyl-N-propylammonium bromide. Controlled yielded polymers a weight dispersity ≤1.3 conversions exceeding 80%. The influence the brushes' composition on their solubility in water organic solvents, interfacial tension at water-oil interface, aggregation behavior aqueous solutions investigated. For first time, we report design combining an antibacterial potential tunable hydrophilic-hydrophobic properties, enabling highly precise control over LCST (17-68 °C) through tuning. solubilization capacity hydrophobic compounds brush micelles increased comonomer content. These exhibited activity, significantly reducing tension, critical micelle concentrations (CMCs) 3-10 mg/L. It shown that amphiphilic properties can be easily tuned desired direction by varying content units. obtained data indicate as micellar nanocarriers for controlled drug delivery.

Язык: Английский

---

Bottlebrush Polymers: From Synthesis to Properties and Applications

Macromolecular Rapid Communications, Год журнала: 2025, Номер unknown

Опубликована: Май 4, 2025

Abstract Bottlebrush polymers (BBPs) have emerged as a special class of macromolecules composed linear backbone the main chain with densely grafted polymeric side chains. BBPs present many unique properties, such low entanglement, high extension backbone, and extremely plateau shear moduli relative to their analogs due distinct conformational topological characteristics. This review summarizes recent significant advances BBPs, from synthetic methods versatile properties applications in areas super‐soft elastomers, photonic crystals, self‐assembly, friction, biomimetic tissues, bio‐interfacial interactions enhance cell penetration anti‐fouling performance, drug delivery, other emerging (polymer electrolyte, catalyst support, covalent adaptable networks). Meanwhile, molecular dynamic simulations are discussed tool disclose relationship between structures properties. will comprehensively summarize studies on point out direction give prediction application trend, comment future BBPs.

Язык: Английский

---