Acta Chimica Sinica, Год журнала: 2023, Номер 81(7), С. 757 - 757
Опубликована: Янв. 1, 2023
孙博 a琚雯雯 a 王涛 孙晓军 赵婷
Coordination Chemistry Reviews, Год журнала: 2024, Номер 512, С. 215876 - 215876
Опубликована: Апрель 26, 2024
The utilization of metal–organic frameworks (MOFs) in energy storage applications is constrained by their limited electrical conductivity and insufficient chemical robustness, posing various challenges limitations. Nevertheless, research has demonstrated that MOF structures with exceptional porosity adaptable architectures yield a wide range composites, presenting promising prospects for improving electrochemical performance devices. When combined other advanced materials, MOFs form composite overcoming these constraints exhibiting superior conductivity, activity, stability comparison to pure MOFs. This article comprehensively overviews the designed chemistry MOF-composites metal-ion batteries (MIBs) capacitors (MICs). synthesis properties composites involving MOFs, including MOF-MXene, MOF-carbon nanomaterials (CNM)/graphene/carbon, MOF-transition metal oxide (TMO), MOF/polymers, MOF-derived layered double hydroxide (LDH), as well mitigation strategies have been discussed. A brief overview electrode materials MIBs, lithium-ion (LIBs), sodium-ion (SIBs), potassium-ion (KIBs) presented. recent developments MICs, such (LICs), magnesium-ion (MGICs), zinc-ion (ZICs), (SICs), (KICs) also included. Furthermore, assessed using metrics, output voltage, capacity, cycle stability, density (ED), power (PD). comprehensive analysis conducted identify potential obstacles possible mitigations explore future possibilities. Overall, comprehension MOF-based approaches enhancing futuristic progression MOF-composite MIBs MICs elucidated.
Язык: Английский
Процитировано
20
RSC Advances, Год журнала: 2024, Номер 14(41), С. 30201 - 30229
Опубликована: Янв. 1, 2024
Recently, metal-organic frameworks (MOFs) have attracted much attention as versatile materials for drug delivery and personalized medicine. MOFs are porous structures made up of metal ions coupled with organic ligands. This review highlights the synthesis techniques used to design specific features such surface area pore size, encapsulation within not only improves their stability solubility but also allows controlled release kinetics, which therapeutic efficacy minimizes adverse effects. Furthermore, it discusses challenges potential advantages MOF-based delivery, MOF stability, biocompatibility, scale-up production. With further advancements in synthesis, functionalization techniques, understanding interactions using biological systems, can significant promise expanding medicine improving patient outcomes.
Язык: Английский
Процитировано
18
ACS Applied Nano Materials, Год журнала: 2023, Номер 7(1), С. 1265 - 1277
Опубликована: Дек. 22, 2023
Herein, the l-serine-functionalized metal–organic framework nanostructure is obtained via a simple two-step post-synthetic modification strategy. Interesting properties of serine, such as existence both acidic and basic groups, provide amphoteric active sites on UiO-66-NH2 that are not accessible through direct synthesis. In this sense, an excess amount 1,6 hexamethylene diisocyanate primarily used linker to allow conversion nucleophilic groups in isocyanate suitable electrophile group. l-serine reacted with generate corresponding urea derivative. SEM, TEM, nitrogen adsorption analyses confirm average particle size approximately 24 nm pore 6.68 within framework. Notably, synthesized nanomaterial exhibited high catalytic activity, stability, durability solvent-free procedures synthesizing diverse range 4H-pyrano[2,3-b] pyridine-3,6-dicarbonitriles octahydropyrimido [4,5 b][1,8]naphthyridine-7-carbonitriles. Moreover, catalyst was easily separated─indicating substantial decrease activity upon five consecutive runs reaction.
Язык: Английский
Процитировано
36
ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(15), С. 18245 - 18251
Опубликована: Апрель 2, 2024
Plant synthetic biology is applied in sustainable agriculture, clean energy, and biopharmaceuticals, addressing crop improvement, pest resistance, plant-based vaccine production by introducing exogenous genes into plants. This technique faces challenges delivering due to plant cell walls intact membranes. Novel approaches are required address this challenge, such as utilizing nanomaterials known for their efficiency biocompatibility gene delivery. work investigates metal-organic frameworks (MOFs) delivery cells infiltration. Hence, small-sized ZIF-8 nanoparticles (below 20 nm) were synthesized demonstrated effective DNA/RNA
Язык: Английский
Процитировано
10
Advanced Materials, Год журнала: 2025, Номер unknown
Опубликована: Фев. 2, 2025
Abstract Despite improvements in cancer survival rates, metastatic and surgery‐resistant cancers, such as pancreatic cancer, remain challenging, with poor prognoses limited treatment options. Enhancing drug bioavailability tumors, while minimizing off‐target effects, is crucial. Metal–organic frameworks (MOFs) have emerged promising delivery vehicles owing to their high loading capacity, biocompatibility, functional tunability. However, the vast chemical diversity of MOFs complicates rational design biocompatible materials. This study employed machine learning molecular simulations identify suitable for encapsulating gemcitabine, paclitaxel, SN‐38, identified PCN‐222 an optimal candidate. Following loading, MOF formulations are improved colloidal stability biocompatibility. In vitro studies on cell lines shown cellular internalization, delayed release. Long‐term tests demonstrated a consistent performance over 12 months. vivo tumor‐bearing mice revealed that paclitaxel‐loaded PCN‐222, particularly hydrogel local administration, significantly reduced spread tumor growth compared free drug. These findings underscore potential effective system hard‐to‐treat cancers.
Язык: Английский
Процитировано
1
ACS Applied Nano Materials, Год журнала: 2025, Номер unknown
Опубликована: Фев. 12, 2025
Язык: Английский
Процитировано
1
Small Structures, Год журнала: 2024, Номер 5(5)
Опубликована: Фев. 9, 2024
This study addresses the fabrication of microporous plasmonic nanocomposites (NCs) by using nanoparticles (i.e., gold bipyramids, AuB) as seeds to grow shells, specifically, metal–organic frameworks (MOF) PCN‐224 increasing thickness from 69 138 nm. method is based on a previously synthesized Zr 6 ‐oxo cluster and unfolds at room temperature. Notably, it demonstrated that concentration AuB determines both yield NCs resultant shell, illustrating seeded growth mechanism. Furthermore, found thermoplasmonic response dominated with thicker shells having enhanced thermal confinement properties than thinner ones. As proof concept, are loaded cresyl violet (CV), lysosomal fluorescent marker. serves demonstrate thermoplasmonic‐induced intracellular release CV photostimulation AuB's near‐infrared (NIR) band. Moreover, display exceptional efficacy photodynamic agents when photostimulated PCN‐224's Soret In summary, this offers facile, efficient, reproducible methodology for controlled geometry while unlocking new possibilities in field nanoMOFs multifunctional theranostic probes.
Язык: Английский
Процитировано
7
Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 197, С. 114829 - 114829
Опубликована: Апрель 28, 2023
The engagement with the immune system is one of main cornerstones in development nanotechnologies for therapy and diagnostics. Recent advances have made possible tuning features like size, shape biomolecular modifications that influence such interactions, however, capabilities modulation nanoparticles are still not well defined exploited. This review focuses on recent preclinical research application to modulate responses, making them relevant applications. We discuss newest evidence field, which include vivo experiments an extensive physicochemical characterization as detailed study induced response. emphasize need incorporating knowledge about response regulation design nanoparticles, including effect by parameters administration route differential interactions subsets.
Язык: Английский
Процитировано
14
ACS Nanoscience Au, Год журнала: 2023, Номер 4(2), С. 85 - 114
Опубликована: Дек. 23, 2023
In the last two decades, metal–organic frameworks (MOFs) with highly tunable structure and porosity, have emerged as drug nanocarriers in biomedical field. particular, nanoscaled MOFs (nanoMOFs) been widely investigated because of their potential biocompatibility, high loadings, progressive release. To enhance properties, combined magnetic nanoparticles (MNPs) to form nanocomposites (MNP@MOF) additional functionalities. Due properties MNPs, presence nanosystems enables combinatorial targeted therapy diagnosis. this Review, we analyze four main synthetic strategies currently employed for fabrication MNP@MOF nanocomposites, namely, mixing, situ formation MNPs presynthesized MOF, layer-by-layer methods. Additionally, discuss current progress bioapplications, focusing on delivery systems (DDSs), resonance imaging (MRI), hyperthermia (MHT), theragnostic systems. Overall, provide a comprehensive overview recent advances development bioapplications highlighting future applications critical analysis challenges limitations these terms synthesis, characterization, applicability.
Язык: Английский
Процитировано
13
Small Science, Год журнала: 2024, Номер 4(8)
Опубликована: Май 10, 2024
Nanoscale metal-organic frameworks (NMOFs) exhibit unique properties for drug delivery, including ultrahigh storage capabilities, biocompatibility, biodegradability, and sustained release of encapsulated cargo. However, due to their localized electronic states, MOFs are nonresponsive external stimuli such as light or magnetic fields. This study investigates the integration light-responsive nanoantennas into NMOFs enhance application smart delivery nanosystems. By integrating gold bipyramid within ZIF-8 NU-1000 NMOFs, core@shell nanosystems created with photothermal capabilities. Utilizing cresyl violet a model drug, loading dynamics these analyzed, demonstrating controlled under near-infrared (NIR) stimulation. Photothermal studies conducted in living cells reveal potential nanocomposites spatiotemporal targeted, light-activated delivery. Further evaluation nanocomposite loaded chemotherapeutics-doxorubicin, carboplatin, oxaliplatin-in both 2D 3D cell cultures shows nanosystem effectiveness internalization therapeutic NIR activation. The findings demonstrate that incorporation stimuli-responsive elements offers promising approach developing advanced platforms.
Язык: Английский
Процитировано
4