Organic Letters,
Год журнала:
2024,
Номер
26(20), С. 4235 - 4239
Опубликована: Май 13, 2024
An
organic
dye
photocatalyzed
lactonization-alkynylation
of
easily
accessible
homoallylic
cesium
oxalates
using
ethynylbenziodoxolone
(EBX)
reagents
has
been
developed.
The
reaction
gave
access
to
valuable
functionalized
lactones
and
lactams
in
up
88%
yield
via
the
formation
two
new
C-C
bonds.
transformation
was
carried
out
on
primary,
secondary,
tertiary
alcohols
primary
amines
could
be
applied
synthesis
spirocyclic
compounds
as
well
fused
bridged
bicyclic
lactones.
JACS Au,
Год журнала:
2025,
Номер
5(2), С. 448 - 465
Опубликована: Фев. 6, 2025
This
Perspective
deals
with
the
organic
chemistry
of
alkynyl
radicals,
a
species
that
is
ultimately
still
little
known
in
synthetic
community.
Starting
first
observations
and
characterizations
radicals
generated
by
various
methodologies
gas
phase,
we
then
particularly
turned
our
attention
to
implications
these
highly
reactive
intermediates
synthesis
materials
science.
Mechanistic
considerations
have
been
provided,
particular,
for
key
steps
generating
which
are
mainly
based
on
photochemical
or
thermal
activation
single
electron
transfer
processes.
should
serve
as
roadmap
chemist
order
plan
more
reliably
alkynylation
reactions
radicals.
Chemistry - An Asian Journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 11, 2025
Abstract
A
metal
free
oxidative
desulfitative
C−N
coupling
reaction
through
activation
of
latent
thiol
group
using
hypervalent
iodine
reagent
is
being
reported
in
eco‐friendly
solvent
ethanol.
Here,
the
thio‐amide
present
5‐alkylidene‐rhodanine
has
been
utilized
as
functionality
and
with
amines
realized.
The
occurs
evading
use
catalysts,
inert
atmosphere,
high
temperature
or
microwave
heating,
strong
base
which
normally
required
for
catalyzed
reaction.
Pertinently,
here
poorly
nucleophilic
aromatic
react
very
efficiently.
Desulfitative
involving
moiety
condition
never
accomplished
one
step,
without
requiring
heating
bases.
at
just
50
°C
few
hours
under
ambient
atmosphere.
Moreover,
no
H
2
S
released
environment,
since
solid
sulphur
precipitated
out
side
product,
making
this
protocol
environmentally
friendly.
Metal
condition,
low
temperature,
non‐toxic
reagent,
prevention
release
environment
make
much
friendly
highly
suitable
a
sustainable
way.
Molecules,
Год журнала:
2025,
Номер
30(8), С. 1711 - 1711
Опубликована: Апрель 11, 2025
Traditionally
employed
as
hydrogenation
reagents,
benzothiazolines
have
emerged
versatile
carbanion
and
radical
transfer
playing
a
vital
role
in
the
construction
of
various
carbon-carbon
bonds.
The
cutting-edge
progress
photochemistry
chemistry
prompted
study
visible
light-driven
reactions,
bringing
into
vibrant
focus.
Their
chemical
processes
been
uncovered
to
encompass
variety
activation
mechanisms,
with
five
distinct
modes
having
identified.
This
work
reviews
innovative
applications
donors
alkyl
or
acyl
groups,
achieving
hydroalkylation
hydroacylation
substitution.
By
examining
their
diverse
this
review
highlights
potential
serving
groups
for
further
research
development.
Moreover,
will
offer
exemplary
inspiration
synthetic
chemists,
contributing
ongoing
evolution
utility
organic
synthesis.
Chinese Journal of Chemistry,
Год журнала:
2024,
Номер
42(15), С. 1686 - 1690
Опубликована: Март 15, 2024
Comprehensive
Summary
A
new,
selective
Ru(II)‐catalyzed
alkynylation
reaction
of
isoquinolones,
quinazolones
and
phthalazinones
with
readily
available
bromoalkynes
has
been
developed.
This
enables
the
construction
a
new
C(sp
2
)‐C(sp)
bond
through
C—H
activation
C—Br
functionalization,
offers
an
effective
route
to
synthesizing
highly
valuable
alkynylated
isoquinolone,
quinazolone
phthalazinone
derivatives
wide
substrate
scope
high
selectivity.
Organic Letters,
Год журнала:
2023,
Номер
26(1), С. 385 - 389
Опубликована: Дек. 27, 2023
An
iodine(III)-catalyzed
general
method
for
the
synthesis
of
fully
functionalized
NH-pyrazoles
and
isoxazoles
from
α,β-unsaturated
hydrazones
oximes,
respectively,
via
cyclization/1,2-aryl
shift/aromatization/detosylation,
has
been
developed.
The
reaction
progresses
through
an
anti-Baldwin
5-endo-trig
cyclization.
It
gives
direct
access
to
advanced
intermediate
preparation
valdecoxib
parecoxib,
drugs
used
COX-inhibition.
In
addition,
a
N-alkynylation
pyrazoles
also
developed
in
presence
TIPS-EBX.
Advanced Synthesis & Catalysis,
Год журнала:
2023,
Номер
365(16), С. 2711 - 2717
Опубликована: Июль 18, 2023
Abstract
An
azidobenziodoxole
(BIN
3
)‐mediated
tunable
radical
reaction
system
for
selective
chlorination
and
bromination
of
tertiary
secondary
C(
sp
)−H
bonds
alkyl
substrates
using
haloform
as
the
halogen
donor
was
developed.
Reactions
various
with
BIN
under
visible
light
irradiation
without
any
photo
or
metal
catalysts
gave
C−H
chlorinated
brominated
products.
These
reactions
are
selective,
compatible
many
functional
groups.
Mechanistic
studies
suggest
that
serves
atom
HN
generated
in
situ
from
water
relays
chain
hydrogen
donor.
reacts
CHX
2
⋅
to
form
CH
X
N
⋅,
which
propagates
a
by
abstracting
alkane
substrate.
