Intraoperative Imaging and Optical Visualization Techniques for Brain Tumor Resection: A Narrative Review

Cancers, Год журнала: 2023, Номер 15(19), С. 4890 - 4890

Опубликована: Окт. 9, 2023

Advancements in intraoperative visualization and imaging techniques are increasingly central to the success safety of brain tumor surgery, leading transformative improvements patient outcomes. This comprehensive review intricately describes evolution conventional emerging technologies for imaging, encompassing surgical microscope, exoscope, Raman spectroscopy, confocal microscopy, fluorescence-guided ultrasound, magnetic resonance computed tomography. We detail how each these modalities contributes uniquely precision, safety, efficacy neurosurgical procedures. Despite their substantial benefits, share common challenges, including difficulties image interpretation steep learning curves. Looking forward, innovations this field poised incorporate artificial intelligence, integrated multimodal approaches, augmented virtual reality technologies. rapidly evolving landscape represents fertile ground future research technological development, aiming further elevate and, most critically, outcomes management tumors.

Язык: Английский

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Facet Dependent Photoluminescence Blinking from Perovskite Nanocrystals

Small, Год журнала: 2024, Номер 20(33)

Опубликована: Март 28, 2024

Photoluminescence (PL) blinking of nanoparticles, while detrimental to their imaging applications, may benefit next-generation displays if the is precisely controlled by reversible electron/hole injections from an external source. Considerable efforts are made create well-characterized charged excitons within nanoparticles through electrochemical charging, which has led enhanced control over PL-blinking in numerous instances. Manipulating photocharging/discharging rates surface engineering can represent a straightforward method for regulating behaviors, area largely unexplored perovskite nanocrystals (PNCs). This work shows facet leading different morphologies PNCs characterized distinct patterns. For instance, examining PL intensity trajectories single PNCs, representing instantaneous photon count rate time, reveals that OFF-state population significantly increases as number facets six twenty-six. study suggests extra-faceted owing polar and expanded area, render them more susceptible photocharging, results larger populations. Furthermore, fluorescence correlation spectroscopy (FCS) unveils augmented propensity photocharging also originate greater tendency form complexes with neighboring molecules.

Язык: Английский

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The optimization and application of photodynamic diagnosis and autofluorescence imaging in tumor diagnosis and guided surgery: current status and future prospects

Frontiers in Oncology, Год журнала: 2025, Номер 14

Опубликована: Янв. 8, 2025

Photodynamic diagnosis (PDD) and autofluorescence imaging (AFI) are emerging cancer diagnostic technologies that offer significant advantages over traditional white-light endoscopy in detecting precancerous lesions early-stage cancers; moreover, they hold promising potential fluorescence-guided surgery (FGS) for tumors. However, their shortcomings have somewhat hindered the clinical application of PDD AFI. Therefore, it is imperative to enhance efficacy AFI, thereby maximizing practical use. This article reviews principles, characteristics, current research status, advancements focusing on analyzing discussing optimization strategies AFI tumor FGS scenarios. Considering technical feasibility, optimizing may result an effective real-time tool guide clinicians surgical guidance achieve best results.

Язык: Английский

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Unveiling the Long-Lived Emission of Copper Nanoclusters Embedded in a Protein Scaffold

The Journal of Physical Chemistry Letters, Год журнала: 2023, Номер 14(40), С. 8979 - 8987

Опубликована: Сен. 29, 2023

Protein-conjugated coinage metal nanoclusters have become promising materials for optoelectronics and biomedical applications. However, the origin of photoluminescence, especially long-lived excited state emission in these nanoclusters, is still elusive. Here, we unveiled underlying mechanism albumin protein-conjugated copper (Cu NCs) using steady time-resolved spectroscopic techniques. Our findings reveal room-temperature phosphorescence (RTP) Cu NCs. Time-resolved area-normalized spectra distinguished short- components, where former arises from singlet latter triplet state, thus resulting RTP. The similarity at room (298 K) cryogenic (77 temperature ascertains RTP phenomenon by harvesting higher-lying states. Time-gated bioimaging A549 cells not only supports cellular environment but also provides exciting avenues long-term bovine serum albumin–conjugated

Язык: Английский

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Intriguing Facets of Solution Processable Cross-Linked Porous Organic Polymers

Accounts of Materials Research, Год журнала: 2024, Номер unknown

Опубликована: Сен. 18, 2024

Язык: Английский

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Fluorescence-Based Enzyme Activity Assay: Ascertaining the Activity and Inhibition of Endocannabinoid Hydrolytic Enzymes

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(14), С. 7693 - 7693

Опубликована: Июль 13, 2024

The endocannabinoid system, known for its regulatory role in various physiological processes, relies on the activities of several hydrolytic enzymes, such as fatty acid amide hydrolase (FAAH), N-acylethanolamine-hydrolyzing amidase (NAAA), monoacylglycerol lipase (MAGL), and α/β-hydrolase domains 6 (ABHD6) 12 (ABHD12), to maintain homeostasis. Accurate measurement these enzymes’ is crucial understanding their function development potential therapeutic agents. Fluorometric assays, which offer high sensitivity, specificity, real-time monitoring capabilities, have become essential tools enzymatic studies. This review provides a comprehensive overview principles behind substrates fluorophores used, advances assay techniques used not only determination kinetic mechanisms enzyme reactions but also setting up assays high-throughput screening each critical involved degradation. Through this review, we aim highlight strengths limitations current fluorometric suggest future directions improving activity system.

Язык: Английский

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Pushing the Boundaries of Covalent Organic Frameworks through Postsynthetic Linker Exchange

ChemNanoMat, Год журнала: 2023, Номер 10(1)

Опубликована: Окт. 24, 2023

Abstract Covalent organic frameworks (COFs) are a fast‐developing family of porous materials that have received substantial research interest during the last two decades. Dynamic covalent chemistry (DCC) is cornerstone COF fabrication. DCC process entails reversible bond breaking‐reforming under equilibrium to attain thermodynamically most stable structure. Due nature linkages, building blocks pre‐synthesized or pre‐assembled chemical entities, like network polymers and supramolecular hosts, can be replaced postsynthetically appropriate reaction conditions. The technique known as postsynthetic linker exchange (PLE). PLE provides an easy way introduce functional into backbone control its physical properties. In this article, we highlighted recent advancements (from 2017 2023) in strategy for constructing highly crystalline COFs often unattainable via de novo mechanistic insights transforming various parent such COFs, amorphous networks, linear polymers, molecular cages daughter been deliberated with fascinating examples. We also outlined some future avenues applying large‐scale fabrication real‐time applications.

Язык: Английский

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Click synthesis and self-assembly of novel dendritic ethylene glycol/alkyl-substituted diarylated triazoles into supramolecular nanofibers

Journal of Molecular Structure, Год журнала: 2023, Номер 1294, С. 136585 - 136585

Опубликована: Сен. 6, 2023

Язык: Английский

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Facet Engineering for Manipulated Photoluminescence Blinking from Perovskite Nanocrystals

Опубликована: Авг. 29, 2023

Photoluminescence (PL) blinking of nanoparticles, while detrimental for their optoelectronic and imaging applications, can be beneficial next-generation displays, especially when is precisely controlled by reversible electron/hole injection from an external source. Efforts have been made toward forming a definite charged state to understand trion-induced PL-blinking electrochemical charging which may lead greater control over PL-blinking. A key parameter deciding the success controllable nanoparticles affinities towards photo-oxidation and/or photo-reduction. This work shows that facet engineering renders perovskite nanocrystals (PNCs) with distinct properties based on number facets. Interestingly, off-duration (τ_off) in PL intensity time-trace fraction time spent off-state surface-immobilized PNC enhance as facets increases six (cube-PNC) twelve (dodecahedron-PNC) and, twenty-six (rhombicuboctahedron-PNC). Our observation suggests affinity photo-charging extra faceted PNCs.

Язык: Английский

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Facile activation of an unconjugated zwitterionic squaraine dye for tunable fluorescence and morphology behaviors

Materials Chemistry Frontiers, Год журнала: 2024, Номер 8(17), С. 2851 - 2858

Опубликована: Янв. 1, 2024

We present a facile method of synthesizing zwitterionic squaraine microcrystals with tunable fluorescence and morphology behaviors by in situ activation π conjugation.

Язык: Английский

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