Abstract
It
is
a
great
challenge
to
discover
novel
chemical
reactions
suitable
for
biological
analysis
in
living
system.
The
development
of
protein
thiol
blocking
agents
crucial
need
exploring
functions
refolding,
signal
transduction,
and
redox
regulation.
We
are
always
keen
on
seeking
applied
endogenous
macromolecules
or
sensing,
blocking,
labeling.
In
the
present
work,
we
have
successfully
developed
agent
block
by
enhanced
electron‐withdrawing
inductive
effects.
This
sensing
process
was
detailedly
monitored
UV‐
vis
,
fluorescent
spectra,
SDS‐Page
gel
separation.
spectral
studies
demonstrated
that
could
react
ultrafastly
with
within
seconds
at
μM
level.
Furthermore,
imaging
cells
vivo
further
used
validation
its
ability
thiol,
providing
evidence
downregulated
thiols
Parkinson's
disease.
effect
strategy
this
work
may
provide
general
guideline
designing
agent.
Chemical Society Reviews,
Год журнала:
2023,
Номер
52(20), С. 7170 - 7196
Опубликована: Янв. 1, 2023
Ion
pairs
comprising
π-electronic
cations
and
anions,
formed
via
i
π–
π
interactions
with
synergetically
worked
electrostatic
dispersion
forces,
their
properties
for
potential
applications
as
functional
materials
are
summarized.
Abstract
It
is
a
great
challenge
to
discover
novel
chemical
reactions
suitable
for
biological
analysis
in
living
system.
The
development
of
protein
thiol
blocking
agents
crucial
need
exploring
functions
refolding,
signal
transduction,
and
redox
regulation.
We
are
always
keen
on
seeking
applied
endogenous
macromolecules
or
sensing,
blocking,
labeling.
In
the
present
work,
we
have
successfully
developed
agent
block
by
enhanced
electron‐withdrawing
inductive
effects.
This
sensing
process
was
detailedly
monitored
UV‐
vis
,
fluorescent
spectra,
SDS‐Page
gel
separation.
spectral
studies
demonstrated
that
could
react
ultrafastly
with
within
seconds
at
μM
level.
Furthermore,
imaging
cells
vivo
further
used
validation
its
ability
thiol,
providing
evidence
downregulated
thiols
Parkinson's
disease.
effect
strategy
this
work
may
provide
general
guideline
designing
agent.
