Progress in Materials Science,
Год журнала:
2024,
Номер
144, С. 101267 - 101267
Опубликована: Фев. 29, 2024
Magnetic
iron
oxide
nanoparticles
(MIPs)
have
garnered
significant
scientific
interest
due
to
their
magnetic
properties
and
unique
features,
including
low
toxicity,
colloidal
stability,
surface
engineering
capability.
Recent
advances
in
nanoparticle
synthesis
enabled
the
development
of
MIPs
with
precise
control
over
physicochemical
properties,
making
them
suitable
for
medical
applications.
Anisotropic
demonstrated
shape-dependent
performance
various
bio-applications,
leading
increased
research
moving
from
traditional
zero-dimensional
(0D)
morphology
towards
one-dimensional
(1D)
two-dimensional
(2D)
topology.
While
these
anisotropic
materials
offer
enhanced
specific
applications,
a
critical
systematic
comparison
anisotropy
effects
is
lacking
literature.
This
review
seeks
fill
this
current
gap
literature
provides
comprehensive
summary
last
two
decades
on
different
shapes
biomedical
The
paper
will
discuss
theoretical
mechanisms
effects,
primary
synthetic
approaches
0D,
1D,
2D
MIP
materials,
biological
behaviors.
In
addition,
identifies
challenges
open
questions
that
need
be
addressed.
proposed
directions
outlined
potential
revitalize
use
"old"
future
(MIPs),
Anisotropic,
Shape-dependent,
Zero-dimensional
(0D),
(1D),
(2D),
MRI,
hyperthermia,
bioapplication.
Abstract
The
tumor
microenvironment
(TME)
has
a
crucial
role
in
development,
metastasis,
and
recurrence.
chaotic
complex
physical
structure
of
the
TME
not
only
limits
drug
delivery
but
also
contributes
to
development
resistance
immunotherapy.
Breaking
barrier
limitation
could
further
optimize
existing
treatment
protocols.
Physical
stimulation,
such
as
ionizing
radiation,
light,
electricity,
magnetic
field,
ultrasound,
modulate
by
altering
vasculature,
remodeling
extracellular
matrix,
activating
immune
responses
achieve
goal
adjuvant
other
therapeutic
approaches.
In
addition
chemotherapy
immunotherapy,
these
stimulations
enhance
efficacy
treatments
for
cancer.
this
review
we
discuss
structural
characteristics
focus
on
modulation
different
stimulations.
We
analyze
effects
therapies.
In
the
system
of
magnesium-loaded
scaffolds,
effect
magnesium
ions
(Mg2+
)
on
osteogenesis
induction
is
restricted
due
to
low
transmembrane
transport
efficiency
Mg2+
into
cell,
which
limits
application
for
bone
defect
repair.
Inspired
by
fact
that
magnetic
field
can
regulate
ion
channel
proteins
cell
membrane,
magnetite
nanoparticle
introduced
poly
(l-lactic
acid)
/magnesium
oxide
composite
in
this
study,
and
a
scaffold
prepared
via
selective
laser
sintering
.
Notably,
activities
protein
(MAGT1)
membrane
marrow
mesenchymal
stem
cells
(rBMSCs)
are
enhanced
torque
(via
integrin
αV
β3/actin),
under
action
static
(SMF),
promoted
rBMSCs
capture
microenvironment
induced
osteogenesis.
vitro
experiments
showed
scaffold,
SMF,
accelerate
inflow
from
surrounding
microenvironment,
improved
cellular
activities,
osteogenesis-related
gene
expression
(ALP,
Runx2,
OCN,
OPN),
mineralization.
Besides,
vivo
skull
repair
scaffolds
possessed
good
ability
promote
differentiation
new
regeneration.
Journal of the American Chemical Society,
Год журнала:
2024,
Номер
146(37), С. 25764 - 25779
Опубликована: Авг. 7, 2024
Photoresponsive
ruthenium(II)
complexes
have
recently
emerged
as
a
promising
tool
for
synergistic
photodynamic
therapy
and
chemotherapy
in
oncology,
well
antimicrobial
applications.
However,
the
limited
penetration
power
of
photons
prevents
treatment
deep-seated
lesions.
In
this
study,
we
introduce
sonoresponsive
ruthenium
complex
capable
generating
superoxide
anion
(O2•–)
via
type
I
process
initiating
ligand
fracture
upon
ultrasound
triggering.
Attaching
hydroxyflavone
(HF)
an
"electron
reservoir"
to
octahedral-polypyridyl-ruthenium
resulted
decreased
highest
occupied
molecular
orbital
(HOMO)–lowest
unoccupied
(LUMO)
energy
gaps
triplet-state
metal
charge
transfer
(3MLCT)
state
(0.89
eV).
This
modification
enhanced
generation
O2•–
under
therapeutic
irradiation
at
frequency
1
MHz.
The
produced
rapidly
induced
intramolecular
cascade
reaction
HF
fracture.
As
proof-of-concept,
engineered
Ru
into
metallopolymer
platform
(PolyRuHF),
which
could
be
activated
by
low-power
(1.5
W
cm–2,
1.0
MHz,
50%
duty
cycle)
within
centimeter
range
tissue.
activation
led
release
cytotoxic
complexes.
Consequently,
PolyRuHF
cellular
apoptosis
ferroptosis
causing
mitochondrial
dysfunction
excessive
toxic
lipid
peroxidation.
Furthermore,
effectively
inhibited
subcutaneous
orthotopic
breast
tumors
prevented
lung
metastasis
downregulating
metastasis-related
proteins
mice.
study
introduces
first
sonodynamic
therapy/sonoactivated
chemotherapy,
offering
new
avenues
deep
tumor
treatment.
Progress in Materials Science,
Год журнала:
2024,
Номер
144, С. 101267 - 101267
Опубликована: Фев. 29, 2024
Magnetic
iron
oxide
nanoparticles
(MIPs)
have
garnered
significant
scientific
interest
due
to
their
magnetic
properties
and
unique
features,
including
low
toxicity,
colloidal
stability,
surface
engineering
capability.
Recent
advances
in
nanoparticle
synthesis
enabled
the
development
of
MIPs
with
precise
control
over
physicochemical
properties,
making
them
suitable
for
medical
applications.
Anisotropic
demonstrated
shape-dependent
performance
various
bio-applications,
leading
increased
research
moving
from
traditional
zero-dimensional
(0D)
morphology
towards
one-dimensional
(1D)
two-dimensional
(2D)
topology.
While
these
anisotropic
materials
offer
enhanced
specific
applications,
a
critical
systematic
comparison
anisotropy
effects
is
lacking
literature.
This
review
seeks
fill
this
current
gap
literature
provides
comprehensive
summary
last
two
decades
on
different
shapes
biomedical
The
paper
will
discuss
theoretical
mechanisms
effects,
primary
synthetic
approaches
0D,
1D,
2D
MIP
materials,
biological
behaviors.
In
addition,
identifies
challenges
open
questions
that
need
be
addressed.
proposed
directions
outlined
potential
revitalize
use
"old"
future
(MIPs),
Anisotropic,
Shape-dependent,
Zero-dimensional
(0D),
(1D),
(2D),
MRI,
hyperthermia,
bioapplication.
