From 0D to 2D: Synthesis and bio-application of anisotropic magnetic iron oxide nanomaterials DOI Creative Commons
Fuqiang Chang, Gemma‐Louise Davies

Progress in Materials Science, Год журнала: 2024, Номер 144, С. 101267 - 101267

Опубликована: Фев. 29, 2024

Magnetic iron oxide nanoparticles (MIPs) have garnered significant scientific interest due to their magnetic properties and unique features, including low toxicity, colloidal stability, surface engineering capability. Recent advances in nanoparticle synthesis enabled the development of MIPs with precise control over physicochemical properties, making them suitable for medical applications. Anisotropic demonstrated shape-dependent performance various bio-applications, leading increased research moving from traditional zero-dimensional (0D) morphology towards one-dimensional (1D) two-dimensional (2D) topology. While these anisotropic materials offer enhanced specific applications, a critical systematic comparison anisotropy effects is lacking literature. This review seeks fill this current gap literature provides comprehensive summary last two decades on different shapes biomedical The paper will discuss theoretical mechanisms effects, primary synthetic approaches 0D, 1D, 2D MIP materials, biological behaviors. In addition, identifies challenges open questions that need be addressed. proposed directions outlined potential revitalize use "old" future (MIPs), Anisotropic, Shape-dependent, Zero-dimensional (0D), (1D), (2D), MRI, hyperthermia, bioapplication.

Язык: Английский

Non-Invasive Physical Stimulation to Modulate the Tumor Microenvironment: Unveiling a New Frontier in Cancer Therapy DOI Creative Commons

Zhili Guo,

Phei Er Saw, Sangyong Jon

и другие.

BIO Integration, Год журнала: 2024, Номер 5(1)

Опубликована: Янв. 1, 2024

Abstract The tumor microenvironment (TME) has a crucial role in development, metastasis, and recurrence. chaotic complex physical structure of the TME not only limits drug delivery but also contributes to development resistance immunotherapy. Breaking barrier limitation could further optimize existing treatment protocols. Physical stimulation, such as ionizing radiation, light, electricity, magnetic field, ultrasound, modulate by altering vasculature, remodeling extracellular matrix, activating immune responses achieve goal adjuvant other therapeutic approaches. In addition chemotherapy immunotherapy, these stimulations enhance efficacy treatments for cancer. this review we discuss structural characteristics focus on modulation different stimulations. We analyze effects therapies.

Язык: Английский

Процитировано

10

Magnetic Field Boosts the Transmembrane Transport Efficiency of Magnesium Ions from PLLA Bone Scaffold DOI

Zuyun Yan,

Tianshi Sun, Wei Tan

и другие.

Small, Год журнала: 2023, Номер 19(40)

Опубликована: Июнь 4, 2023

In the system of magnesium-loaded scaffolds, effect magnesium ions (Mg2+ ) on osteogenesis induction is restricted due to low transmembrane transport efficiency Mg2+ into cell, which limits application for bone defect repair. Inspired by fact that magnetic field can regulate ion channel proteins cell membrane, magnetite nanoparticle introduced poly (l-lactic acid) /magnesium oxide composite in this study, and a scaffold prepared via selective laser sintering . Notably, activities protein (MAGT1) membrane marrow mesenchymal stem cells (rBMSCs) are enhanced torque (via integrin αV β3/actin), under action static (SMF), promoted rBMSCs capture microenvironment induced osteogenesis. vitro experiments showed scaffold, SMF, accelerate inflow from surrounding microenvironment, improved cellular activities, osteogenesis-related gene expression (ALP, Runx2, OCN, OPN), mineralization. Besides, vivo skull repair scaffolds possessed good ability promote differentiation new regeneration.

Язык: Английский

Процитировано

22

Ultrasound-nanovesicles interplay for theranostics DOI
Jingyi Liu, Qing You, Fuming Liang

и другие.

Advanced Drug Delivery Reviews, Год журнала: 2024, Номер 205, С. 115176 - 115176

Опубликована: Янв. 9, 2024

Язык: Английский

Процитировано

9

Sonoinduced Tumor Therapy and Metastasis Inhibition by a Ruthenium Complex with Dual Action: Superoxide Anion Sensitization and Ligand Fracture DOI
Maomao He, Zhiyuan Ma, Linhao Zhang

и другие.

Journal of the American Chemical Society, Год журнала: 2024, Номер 146(37), С. 25764 - 25779

Опубликована: Авг. 7, 2024

Photoresponsive ruthenium(II) complexes have recently emerged as a promising tool for synergistic photodynamic therapy and chemotherapy in oncology, well antimicrobial applications. However, the limited penetration power of photons prevents treatment deep-seated lesions. In this study, we introduce sonoresponsive ruthenium complex capable generating superoxide anion (O2•–) via type I process initiating ligand fracture upon ultrasound triggering. Attaching hydroxyflavone (HF) an "electron reservoir" to octahedral-polypyridyl-ruthenium resulted decreased highest occupied molecular orbital (HOMO)–lowest unoccupied (LUMO) energy gaps triplet-state metal charge transfer (3MLCT) state (0.89 eV). This modification enhanced generation O2•– under therapeutic irradiation at frequency 1 MHz. The produced rapidly induced intramolecular cascade reaction HF fracture. As proof-of-concept, engineered Ru into metallopolymer platform (PolyRuHF), which could be activated by low-power (1.5 W cm–2, 1.0 MHz, 50% duty cycle) within centimeter range tissue. activation led release cytotoxic complexes. Consequently, PolyRuHF cellular apoptosis ferroptosis causing mitochondrial dysfunction excessive toxic lipid peroxidation. Furthermore, effectively inhibited subcutaneous orthotopic breast tumors prevented lung metastasis downregulating metastasis-related proteins mice. study introduces first sonodynamic therapy/sonoactivated chemotherapy, offering new avenues deep tumor treatment.

Язык: Английский

Процитировано

9

From 0D to 2D: Synthesis and bio-application of anisotropic magnetic iron oxide nanomaterials DOI Creative Commons
Fuqiang Chang, Gemma‐Louise Davies

Progress in Materials Science, Год журнала: 2024, Номер 144, С. 101267 - 101267

Опубликована: Фев. 29, 2024

Magnetic iron oxide nanoparticles (MIPs) have garnered significant scientific interest due to their magnetic properties and unique features, including low toxicity, colloidal stability, surface engineering capability. Recent advances in nanoparticle synthesis enabled the development of MIPs with precise control over physicochemical properties, making them suitable for medical applications. Anisotropic demonstrated shape-dependent performance various bio-applications, leading increased research moving from traditional zero-dimensional (0D) morphology towards one-dimensional (1D) two-dimensional (2D) topology. While these anisotropic materials offer enhanced specific applications, a critical systematic comparison anisotropy effects is lacking literature. This review seeks fill this current gap literature provides comprehensive summary last two decades on different shapes biomedical The paper will discuss theoretical mechanisms effects, primary synthetic approaches 0D, 1D, 2D MIP materials, biological behaviors. In addition, identifies challenges open questions that need be addressed. proposed directions outlined potential revitalize use "old" future (MIPs), Anisotropic, Shape-dependent, Zero-dimensional (0D), (1D), (2D), MRI, hyperthermia, bioapplication.

Язык: Английский

Процитировано

8