Non-Invasive Physical Stimulation to Modulate the Tumor Microenvironment: Unveiling a New Frontier in Cancer Therapy

BIO Integration, Год журнала: 2024, Номер 5(1)

Опубликована: Янв. 1, 2024

Abstract The tumor microenvironment (TME) has a crucial role in development, metastasis, and recurrence. chaotic complex physical structure of the TME not only limits drug delivery but also contributes to development resistance immunotherapy. Breaking barrier limitation could further optimize existing treatment protocols. Physical stimulation, such as ionizing radiation, light, electricity, magnetic field, ultrasound, modulate by altering vasculature, remodeling extracellular matrix, activating immune responses achieve goal adjuvant other therapeutic approaches. In addition chemotherapy immunotherapy, these stimulations enhance efficacy treatments for cancer. this review we discuss structural characteristics focus on modulation different stimulations. We analyze effects therapies.

Язык: Английский

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Magnetic Field Boosts the Transmembrane Transport Efficiency of Magnesium Ions from PLLA Bone Scaffold

Small, Год журнала: 2023, Номер 19(40)

Опубликована: Июнь 4, 2023

In the system of magnesium-loaded scaffolds, effect magnesium ions (Mg2+ ) on osteogenesis induction is restricted due to low transmembrane transport efficiency Mg2+ into cell, which limits application for bone defect repair. Inspired by fact that magnetic field can regulate ion channel proteins cell membrane, magnetite nanoparticle introduced poly (l-lactic acid) /magnesium oxide composite in this study, and a scaffold prepared via selective laser sintering . Notably, activities protein (MAGT1) membrane marrow mesenchymal stem cells (rBMSCs) are enhanced torque (via integrin αV β3/actin), under action static (SMF), promoted rBMSCs capture microenvironment induced osteogenesis. vitro experiments showed scaffold, SMF, accelerate inflow from surrounding microenvironment, improved cellular activities, osteogenesis-related gene expression (ALP, Runx2, OCN, OPN), mineralization. Besides, vivo skull repair scaffolds possessed good ability promote differentiation new regeneration.

Язык: Английский

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Ultrasound-nanovesicles interplay for theranostics

Advanced Drug Delivery Reviews, Год журнала: 2024, Номер 205, С. 115176 - 115176

Опубликована: Янв. 9, 2024

Язык: Английский

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From 0D to 2D: Synthesis and bio-application of anisotropic magnetic iron oxide nanomaterials

Progress in Materials Science, Год журнала: 2024, Номер 144, С. 101267 - 101267

Опубликована: Фев. 29, 2024

Magnetic iron oxide nanoparticles (MIPs) have garnered significant scientific interest due to their magnetic properties and unique features, including low toxicity, colloidal stability, surface engineering capability. Recent advances in nanoparticle synthesis enabled the development of MIPs with precise control over physicochemical properties, making them suitable for medical applications. Anisotropic demonstrated shape-dependent performance various bio-applications, leading increased research moving from traditional zero-dimensional (0D) morphology towards one-dimensional (1D) two-dimensional (2D) topology. While these anisotropic materials offer enhanced specific applications, a critical systematic comparison anisotropy effects is lacking literature. This review seeks fill this current gap literature provides comprehensive summary last two decades on different shapes biomedical The paper will discuss theoretical mechanisms effects, primary synthetic approaches 0D, 1D, 2D MIP materials, biological behaviors. In addition, identifies challenges open questions that need be addressed. proposed directions outlined potential revitalize use "old" future (MIPs), Anisotropic, Shape-dependent, Zero-dimensional (0D), (1D), (2D), MRI, hyperthermia, bioapplication.

Язык: Английский

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Transformative breakthrough in cancer phototheranostics utilizing bioinspired chemistry of polydopamine-based multifunctional nanostructures

Coordination Chemistry Reviews, Год журнала: 2024, Номер 518, С. 216043 - 216043

Опубликована: Июль 3, 2024

Язык: Английский

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