Journal of the American Chemical Society,
Год журнала:
2024,
Номер
146(12), С. 8343 - 8351
Опубликована: Март 18, 2024
In
this
work,
we
explore
a
nickel-catalyzed
reversible
carbon–sulfur
(C–S)
bond
activation
strategy
to
achieve
selective
sulfur
isotope
exchange.
Isotopes
are
at
the
foundation
of
applications
in
life
science,
such
as
nuclear
imaging,
and
essential
tools
for
determination
pharmacokinetic
dynamic
profiles
new
pharmaceuticals.
However,
insertion
an
into
organic
molecule
remains
challenging,
current
technologies
element-specific.
Despite
ubiquitous
presence
many
biologically
active
molecules,
labeling
is
underexplored
field,
exchange
has
been
overlooked.
This
approach
enables
us
move
beyond
standardized
element-specific
procedures
was
applied
multiple
isotopes,
including
deuterium,
carbon-13,
sulfur-34,
radioactive
carbon-14.
These
results
provide
unique
platform
compatible
with
wide
range
substrates,
addition,
technology
proved
its
potential
isotopic
encryption
device
molecules.
Inorganic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 15, 2025
Developing
new
photocatalysts
for
the
selective
oxidation
of
thioethers
to
high-value-added
sulfoxides
under
low-oxygen
mild
conditions
is
a
promising
but
challenging
strategy.
Here,
polyoxometalate-based
metal–organic
framework
(POMOF),
CoBW12–TPT,
was
successfully
synthesized,
wherein
continuous
π···π
stacking
interactions
and
direct
coordination
bonds
not
only
strengthen
framework's
stability
also
accelerate
electron
transfer.
A
series
experiments
theoretical
studies,
including
control
experiments,
kinetic
electrochemical
spectroscopic
analyses,
paramagnetic
resonance,
revealed
synergistic
catalytic
effect
among
Co(II)
metal
centers,
BW12O405–,
photosensitizer
TPT.
CoBW12–TPT
applied
in
photocatalytic
sulfoxides.
Under
irradiation,
photoinduced
transfer
POMOF
leads
generation
superoxide
radicals
from
O2,
which
controls
sulfoxide
compounds
desulfurization
reaction
shows
good
activity.
In
particular,
it
can
be
construction
some
drug
molecules
such
as
Modafinil
Albendazole
Oxide.
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
62(16)
Опубликована: Фев. 27, 2023
Although
the
direct
conversion
of
gaseous
acetylene
into
value-added
liquid
commodity
chemicals
is
becoming
increasingly
attractive,
majority
established
methodologies
are
focused
on
cross-coupling,
hydro-functionalization,
and
polymerization.
Herein,
we
describe
a
1,2-difunctionalization
method
that
inserts
directly
readily
available
bifunctional
reagents.
This
provides
access
to
diverse
C2-linked
1,2-bis-heteroatom
products
in
high
regio-
stereoselectivity
along
with
opening
up
previously
unexplored
synthetic
directions.
In
addition,
demonstrate
this
method's
potential
by
converting
obtained
functionalized
molecules
chiral
sulfoxide-containing
bidentate
ligands.
Using
combination
experimental
theoretical
methods,
mechanism
for
insertion
reaction
was
investigated.
Organic Chemistry Frontiers,
Год журнала:
2023,
Номер
10(19), С. 4764 - 4773
Опубликована: Янв. 1, 2023
A
photo-induced
iron-catalyzed
strategy
that
facilitates
the
transformation
of
carboxylic
acids
and
hydrocarbons
into
thioethers
sulfoxides
is
herein
reported.
Organic Chemistry Frontiers,
Год журнала:
2023,
Номер
10(20), С. 5171 - 5179
Опубликована: Янв. 1, 2023
We
report
a
cross-electrophile
coupling
of
aryl
thiols
with
bromides
via
C–S
bond
activation
instead
S–H
cleavage.
The
reaction
proceeded
effectively
in
the
presence
nickel
catalyst,
magnesium,
and
lithium
chloride
to
afford
various
biaryls
moderate
good
yields.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(18), С. 5278 - 5305
Опубликована: Янв. 1, 2024
This
review
summarizes
the
latest
methodological
advances
in
photocatalytic
C(sp
3
)–H
functionalization,
with
a
particular
emphasis
on
formation
of
C–P,
C–B,
C–S
bonds,
etc
.,
and
some
prominent
efforts
asymmetric
C–H
functionalization.
Green Synthesis and Catalysis,
Год журнала:
2024,
Номер
5(4), С. 211 - 269
Опубликована: Май 6, 2024
The
development
of
catalytic
carbonylation
reactions
has
increased
considerably.
Although
many
reviews/chapters/books
on
have
been
published,
summaries
cheap
metal-catalyzed
aryl
halides
and
other
chemical
bonds
with
high
dissociation
energy
C-Y
(Y
=
O,
N,
H)
are
still
very
rare.
Focusing
green
sustainable
chemistry,
this
review
summarizes
discusses
the
achievements
carbonylative
transformations
(C(sp2)-X)
strong
based
non-expensive
metal
catalysts
(Co,
Mn,
Mo,
Ni,
Fe,
Cu),
photochemical
electrochemical
systems
developed
in
recent
decades.
Organic Letters,
Год журнала:
2024,
Номер
26(18), С. 3828 - 3833
Опубликована: Апрель 29, 2024
The
photocatalyzed
radical-triggered
thio/selenosulfonylation–bicyclization
of
indole-tethered
1,6-enynes
has
been
established
for
the
first
time,
enabling
synthesis
various
previously
unreported
thio/selenosulfonylated
benzo[c]pyrrolo[1,2,3-lm]carbazoles
with
moderate
to
good
yields
under
mild
conditions.
reaction
pathway
was
proposed,
consisting
energy
transfer,
homolytic
cleavage,
radical
addition,
5-exo-dig,
coupling,
and
a
Mallory
cascade.
This
approach
exhibits
wide
substrate
compatibility
excellent
tolerability
toward
functional
groups
is
characterized
by
its
remarkable
efficiency
in
both
bond
formation
annulation.
ACS Catalysis,
Год журнала:
2024,
Номер
14(9), С. 6451 - 6461
Опубликована: Апрель 12, 2024
Given
the
abundance
of
alcohol
feedstocks
and
significance
disulfides,
we
herein
report
a
nickel-catalyzed
direct
deoxygenative
disulfuration
alcohols
with
trisulfide
dioxides
to
access
wide
range
disulfide
molecules
without
cumbersome
decoration
coupling
partners.
The
use
readily
available
dicyclohexylcarbodiimide
form
transient
isoureas
provides
activation
high
bond
dissociation
energy
C–O
bond,
which
facilitates
straightforward
conversion
nonderivatized
forge
C–SS
bond.
Notably,
this
method
obviates
preactivation
multistep
procedure
catalytic
turnover
under
exogenous
ligand
base-free
conditions,
featuring
broad
substrate
scope
functional
group
compatibility.
It
thus
offers
robust
alternative
existing
methods
for
precise
construction
versatile
compounds
from
more
abundant
commercially
substrates.
synthetic
utility
was
further
showcased
by
successful
gram-scale
experiments
structurally
complex
pharmaceuticals.
