Pharmaceutics,
Год журнала:
2024,
Номер
16(2), С. 286 - 286
Опубликована: Фев. 17, 2024
Transdermal
drug
delivery
systems
are
rapidly
gaining
prominence
and
have
found
widespread
application
in
the
treatment
of
numerous
diseases.
However,
they
encounter
challenge
a
low
transdermal
absorption
rate.
Microneedles
can
overcome
stratum
corneum
barrier
to
enhance
Among
various
types
microneedles,
nanoparticle-loaded
dissolving
microneedles
(DMNs)
present
unique
combination
advantages,
leveraging
strengths
DMNs
(high
payload,
good
mechanical
properties,
easy
fabrication)
nanocarriers
(satisfactory
solubilization
capacity
controlled
release
profile).
Consequently,
hold
considerable
clinical
potential
precision
medicine
era.
Despite
this
promise,
no
DMN
products
been
approved
thus
far.
The
lack
understanding
regarding
their
vivo
fate
represents
critical
bottleneck
impeding
translation
relevant
products.
This
review
aims
elucidate
current
research
status
elaborate
necessity
investigate
from
diverse
aspects.
Furthermore,
it
offers
insights
into
entry
points
for
DMNs,
aiming
foster
further
advancements
field.
RSC Advances,
Год журнала:
2024,
Номер
14(5), С. 3010 - 3023
Опубликована: Янв. 1, 2024
Beta-galactosidase
(β-galactosidase),
a
lysosomal
hydrolytic
enzyme,
plays
critical
role
in
the
catalytic
hydrolysis
of
glycosidic
bonds,
leading
to
conversion
lactose
into
galactose.
Abstract
The
blood‐brain
barrier
(BBB)
is
a
substantial
impediment
to
effectively
delivering
central
nervous
system
(CNS)
therapies.
In
this
review,
we
provide
comprehensive
dissection
of
the
BBB's
elaborate
structure
and
function
discuss
inherent
limitations
conventional
drug
delivery
mechanisms
due
its
impermeability.
We
summarized
creative
deployment
nanocarriers,
astute
modification
small
molecules
bolster
their
CNS
penetration
capabilities
as
well
burgeoning
potential
magnetic
nanoparticles
optical
techniques
that
are
positioned
enable
more
precise
targeted
across
BBB
current
clinical
application
some
nanomedicines.
addition,
emphasize
indispensable
role
artificial
intelligence
in
designing
novel
materials
paramount
significance
interdisciplinary
research
surmounting
challenges
associated
with
penetration.
Our
review
meticulously
integrates
these
insights
accentuate
impact
nanotechnological
innovations
disease
management.
It
presents
promising
trajectory
for
evolution
patient
care
neurological
disorders
suggests
scientific
strides
could
lead
efficacious
treatments
improved
outcomes
those
afflicted
such
conditions.
Pharmaceutics,
Год журнала:
2024,
Номер
16(2), С. 286 - 286
Опубликована: Фев. 17, 2024
Transdermal
drug
delivery
systems
are
rapidly
gaining
prominence
and
have
found
widespread
application
in
the
treatment
of
numerous
diseases.
However,
they
encounter
challenge
a
low
transdermal
absorption
rate.
Microneedles
can
overcome
stratum
corneum
barrier
to
enhance
Among
various
types
microneedles,
nanoparticle-loaded
dissolving
microneedles
(DMNs)
present
unique
combination
advantages,
leveraging
strengths
DMNs
(high
payload,
good
mechanical
properties,
easy
fabrication)
nanocarriers
(satisfactory
solubilization
capacity
controlled
release
profile).
Consequently,
hold
considerable
clinical
potential
precision
medicine
era.
Despite
this
promise,
no
DMN
products
been
approved
thus
far.
The
lack
understanding
regarding
their
vivo
fate
represents
critical
bottleneck
impeding
translation
relevant
products.
This
review
aims
elucidate
current
research
status
elaborate
necessity
investigate
from
diverse
aspects.
Furthermore,
it
offers
insights
into
entry
points
for
DMNs,
aiming
foster
further
advancements
field.
