Recent Advances in Peptide-Functionalized Hydrogels for Bone Tissue Engineering

ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown

Опубликована: Апрель 3, 2025

Efficient therapeutic approaches for bone regeneration are urgently required to address the significant challenges associated with repair of large-scale or long-segment defects. Peptide-functionalized hydrogels (PFHs) have emerged as important bioactive materials in tissue engineering because they produce biomimetic microenvironments enriched multiple biochemical signals. This review summarizes key fabrication techniques PFHs and discusses their diverse applications different fields. Furthermore, we systematically highlighted functionalization PFHs, which includes basic functions such cell adhesion, recruitment, osteoinduction; improved angiogenesis, biomineralization, immune regulation, hormone regulation; other functions, including antimicrobial antitumor effects. Finally, critical biosafety considerations perspectives on developing intelligent addressed. aims inspire further research accelerate engineering.

Язык: Английский

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Biomimetic Mineralization Effect of a Self-etch Adhesive Loaded with Amorphous Fluorinated Calcium Phosphate Nanoparticles

Journal of Dentistry, Год журнала: 2025, Номер unknown, С. 105743 - 105743

Опубликована: Апрель 1, 2025

Язык: Английский

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R5 Peptides Constitute Condensed Phases with Liquid-Like Properties in Biomimetic Silica Capsules

The Journal of Physical Chemistry Letters, Год журнала: 2025, Номер unknown, С. 4326 - 4335

Опубликована: Апрель 23, 2025

Biomimetic silica-peptide nanocomposites are promising materials for applications in drug delivery and enzyme encapsulation due to their biocompatibility, tunable morphologies, unique structural characteristics. However, the dynamics of peptide scaffold remain largely elusive, impeding rational biomimetic design. This shortcoming is not least a lack methods that can access such heterogeneous systems with on wide range time scales. Among most studied candidates silica particles templated by diatom-derived R5, known its ability guide precipitation under mild, toxicologically friendly conditions, leading capsules filled scaffold. Here, we describe R5 within self-assemblies it templates combination advanced magnetic resonance methods, including 13C-direct detected NMR, site-directive spin-labeling EPR, sensitivity-enhanced solid-state NMR. We provide evidence form condensed phases liquid-like both before after encapsulation. Our suite allowed us R5/silica composites over comprehensive These results demonstrate retains remarkable degree internal dynamics, distinct regions solid-like behavior even particles. Specifically, comprises three dynamic species: (i) at peptide-silica interface, (ii) mobility core, (iii) intermediate boundary between core interface species. findings rationalize high guest molecules, as drugs or substrates, R5-silica nanoparticles, which crucial functionality controlled release catalytic applications. understanding paves way improved design considerations nanomaterials expands our knowledge mineralization mechanisms. At same time, methodological approach be useful many types peptide-guided biominerals, bridging fundamental biochemistry biotechnological innovation.

Язык: Английский

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Facile peptide-mediated green synthesis of iron hexacyanocobalt nanostructures for efficient intercalative deionization and water disinfection

Separation and Purification Technology, Год журнала: 2024, Номер 354, С. 128779 - 128779

Опубликована: Июль 14, 2024

Язык: Английский

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Microbial Protective Shells: A powerful tool for enhancing the bioremediation of environmental contaminants

Journal of environmental chemical engineering, Год журнала: 2025, Номер unknown, С. 116781 - 116781

Опубликована: Апрель 1, 2025

Язык: Английский

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