An ER‐targeted, Viscosity‐sensitive Hemicyanine Dye for the Diagnosis of Nonalcoholic Fatty Liver and Photodynamic Cancer Therapy by Activating Pyroptosis Pathway

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(9)

Опубликована: Янв. 10, 2024

The concept of molecular design, integrating diagnostic and therapeutic functions, aligns with the general trend modern medical advancement. Herein, we rationally designed smart molecule ER-ZS for endoplasmic reticulum (ER)-targeted diagnosis treatment in cell animal models by combining hemicyanine dyes ER-targeted functional groups (p-toluenesulfonamide). Owing to its ability target ER a highly specific response viscosity, demonstrated substantial fluorescence turn-on only after binding ER, independent other physiological environments. In addition, ER-ZS, being small molecule, allows nonalcoholic fatty liver disease (NAFLD) via imaging based on high stress. Importantly, is type I photosensitizer, producing O

Язык: Английский

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Bienzyme-Locked Activatable Fluorescent Probes for Specific Imaging of Tumor-Associated Mast Cells

Journal of the American Chemical Society, Год журнала: 2024, Номер 146(18), С. 12656 - 12663

Опубликована: Апрель 29, 2024

Tumor-associated mast cells (TAMCs) have been recently revealed to play a multifaceted role in the tumor microenvironment. Noninvasive optical imaging of TAMCs is thus highly desired gain insights into their functions cancer immunotherapy. However, due lack single enzyme that specific cells, common probe design approach based on single-enzyme activation not applicable. Herein, we reported bienzyme-locked molecular (THCMC) photoinduced electron transfer-intramolecular charge-transfer hybrid strategy for vivo TAMCs. The mechanism ensures THCMC exclusively turns near-infrared (NIR) fluorescence only presence both tryptase and chymase specifically coexpressed by cells. Thus, effectively distinguishes from other leukocytes, including T neutrophils, macrophages, capability lacking single-locked probes. Such high specificity allows noninvasive tracking fluctuation living mice during results reveal decreased intratumoral signal after combination immunotherapy correlates well with reduced population TAMCs, accurately predicting inhibition growth. this study presents first NIR fluorescent but also proposes generic cell imaging.

Язык: Английский

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Tumor-microenvironment-activatable organic phototheranostic agents for cancer therapy

Coordination Chemistry Reviews, Год журнала: 2024, Номер 509, С. 215786 - 215786

Опубликована: Март 20, 2024

Язык: Английский

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Chelation strategies in spiropyran-based chemosensors for colorimetric and fluorescent sensing of metal ions and anions

Coordination Chemistry Reviews, Год журнала: 2024, Номер 508, С. 215779 - 215779

Опубликована: Март 14, 2024

Язык: Английский

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A Dual Fluorescence Turn‐On Sensor Array Formed by Poly(para‐aryleneethynylene) and Aggregation‐Induced Emission Fluorophores for Sensitive Multiplexed Bacterial Recognition

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(16)

Опубликована: Фев. 26, 2024

Bacterial infections have emerged as the leading causes of mortality and morbidity worldwide. Herein, we developed a dual-channel fluorescence "turn-on" sensor array, comprising six electrostatic complexes formed from one negatively charged poly(para-aryleneethynylene) (PPE) positively aggregation-induced emission (AIE) fluorophores. The 6-element array enabled simultaneous identification 20 bacteria (OD

Язык: Английский

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Recent advances in the design of organic photothermal agents for cancer treatment: A review

Coordination Chemistry Reviews, Год журнала: 2024, Номер 506, С. 215719 - 215719

Опубликована: Фев. 24, 2024

Язык: Английский

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Dissecting lysosomal viscosity fluctuations in live cells and liver tissues with an ingenious NIR fluorescent probe

Talanta, Год журнала: 2024, Номер 272, С. 125825 - 125825

Опубликована: Фев. 23, 2024

Язык: Английский

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General (hetero)polyaryl amine synthesis via multicomponent cycloaromatization of amines

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Янв. 2, 2025

Язык: Английский

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Amphiphilic hemicyanine molecular probes crossing the blood-brain barrier for intracranial optical imaging of glioblastoma

Science Advances, Год журнала: 2025, Номер 11(3)

Опубликована: Янв. 15, 2025

Intracranial optical imaging of glioblastoma (GBM) is challenging due to the scarcity effective probes with blood-brain barrier (BBB) permeability and sufficient depth. Herein, we describe a rational strategy for designing crossing BBB based on an electron donor-π-acceptor system adjust lipid/water partition coefficient molecular weight probes. The amphiphilic hemicyanine dye (namely, IVTPO), which exhibits remarkable properties permeability, chosen as efficient fluorescence/photoacoustic probe in vivo real-time orthotopic GBM high resolution through intact skull. Abnormal leakage IVTPO adjacent developing tumor unambiguously observed at early stage development prior impairment integrity, assessed by commercial Evans blue (EB). Compared EB, demonstrates enhanced capability improved tumor-targeting efficacy. These results offer encouraging insights into medical diagnosis intracranial GBM.

Язык: Английский

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Real-Time Monitoring of ONOO⁻ in Cerebral Ischemia-Reperfusion Injury Mouse Models Using a Hydrazine-Based NIR Fluorescent Probe

Redox Biology, Год журнала: 2025, Номер 80, С. 103494 - 103494

Опубликована: Янв. 13, 2025

Accurate and selective techniques for visualizing endogenous peroxynitrite (ONOO-) in cerebral ischemia-reperfusion injury (CIRI) models are essential understanding its complex pathological processes. Here, we introduced a longwave fluorescent probe TJO detecting ONOO- rapidly sensitively, with low detection limit of 91 nM. Furthermore, exhibits excellent fluorescence imaging capabilities, enabling detailed visualization ONOO⁻ CIRI mice model. This highlights potential real-time monitoring ONOO⁻-related conditions.

Язык: Английский

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