Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(41)
Опубликована: Июль 16, 2024
The
excessive
and
prolonged
use
of
antibiotics
contributes
to
the
emergence
drug-resistant
S.
aureus
strains
potential
dysbacteriosis-related
diseases,
necessitating
exploration
alternative
therapeutic
approaches.
Herein,
we
present
a
light-activated
nanocatalyst
for
synthesizing
in
situ
antimicrobials
through
photoredox-catalytic
click
reaction,
achieving
precise,
site-directed
elimination
skin
infections.
Methylene
blue
(MB),
commercially
available
photosensitizer,
was
encapsulated
within
Cu
Journal of Medicinal Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 31, 2025
Bioorthogonal
chemistry-based
prodrug
strategy
features
spatiotemporally
controlled
release
of
therapeutic
agent
and/or
imaging
probe.
However,
the
integration
diagnosis
and
therapy
into
a
single
molecule
paired
with
bioorthogonal
trigger
remains
challenge.
In
this
study,
we
devised
novel
theranostic
scaffold
amenable
to
conjugation
various
targeting
click-to-release
reaction
enable
targeted
drug
liberation
concomitant
fluorescence
emission.
Such
one-stone-three-birds
consists
new
fluorophore
phenanthrodioxine
(PDO)
linked
masking
group,
tetrazine
(Tz)
which
serves
as
dual
switch
for
activation
drug.
Further
installation
warhead
phenylboronic
acid
(PBA)
ensures
accumulation
resultant
PBA-PDO-Tz
conjugate
in
tumor
cells,
thereby
achieving
on-demand
trans-cyclooctene-caged
anticancer
Doxorubicin
real-time
monitoring
on-target
cytotoxicity
live
cells
an
A549
xenograft
mouse
model.
The
trigger-dual
response
holds
promise
precise
theranostics
applications
vivo.
Journal of Medicinal Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 21, 2025
Nitrogen
mustard,
a
widely
used
chemotherapeutic
agent
for
more
than
70
years,
exhibits
significant
efficacy.
However,
its
clinical
applications
are
severely
limited
by
poor
tumor
selectivity
and
severe
side
effects
on
normal
tissues.
To
address
these
limitations,
we
developed
near-infrared
(NIR)-activatable
nitrogen
mustard
prodrug,
MBNM.
Upon
NIR
irradiation,
the
controlled
cleavage
of
urea
bond
within
MBNM
facilitates
simultaneous
release
methylene
blue
(MB),
enabling
synergistic
approach
combining
chemotherapy
photodynamic
therapy
(PDT)
effective
suppression.
Moreover,
MB
upon
activation
enables
real-time
monitoring
prodrug
activation.
Notably,
demonstrated
significantly
improved
biosafety
compared
to
free
mustard.
These
findings
suggest
that
photocleavable
offers
promising
strategy
safe
combination
cancer
therapy.
Journal of Medicinal Chemistry,
Год журнала:
2023,
Номер
66(24), С. 16546 - 16567
Опубликована: Дек. 12, 2023
Time-
and
space-resolved
drug
delivery
is
highly
demanded
for
cancer
treatment,
which,
however,
can
barely
be
achieved
with
a
traditional
prodrug
strategy.
In
recent
years,
the
strategy
based
on
bioorthogonal
bond
cleavage
chemistry
has
emerged
advantages
of
high
temporospatial
resolution
over
activation
homogeneous
irrespective
individual
heterogeneity.
past
five
tremendous
progress
been
witnessed
in
this
field
one
such
entering
Phase
II
clinical
trials.
This
Perspective
aims
to
highlight
these
new
advances
(2019–2023)
critically
discuss
their
pros
cons.
addition,
remaining
challenges
potential
strategic
directions
future
will
also
included.
Advanced Materials,
Год журнала:
2024,
Номер
36(41)
Опубликована: Авг. 16, 2024
Abstract
Bioorthogonal
chemistry
has
provided
an
elaborate
arsenal
to
manipulate
native
biological
processes
in
living
systems.
As
the
great
advancement
of
nanotechnology
recent
years,
bioorthogonal
nanozymes
are
innovated
tackle
challenges
that
emerged
practical
biomedical
applications.
uniquely
positioned
owing
their
advantages
high
customizability
and
tunability,
as
well
good
adaptability
systems,
which
bring
exciting
opportunities
for
More
intriguingly,
offers
opportunity
innovating
catalytic
materials.
In
this
comprehensive
review,
significant
progresses
discussed
with
both
spatiotemporal
controllability
performance
highlight
design
principles
rapid
The
remaining
future
perspectives
then
outlined
along
thriving
field.
It
is
expected
review
will
inspire
promote
novel
nanozymes,
facilitate
clinical
translation.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(4), С. 1437 - 1437
Опубликована: Фев. 8, 2025
Photodynamic
therapy
(PDT)
involves
the
use
of
photosensitizers
(PSs)
that,
upon
activation
by
specific
wavelengths
light,
generate
reactive
oxygen
species
(ROS),
including
singlet
(1O2)
and
hydroxyl
radicals
(·OH),
within
targeted
tissue,
typically
tumor
cells.
The
generated
ROS
induces
cellular
damage,
disrupts
processes,
ultimately
leads
to
apoptosis
or
necrosis
However,
clinical
application
PDT
is
significantly
hindered
limited
tissue
penetration
ability
light.
To
address
this
limitation,
laser-free
self-luminescent
photosensitive
systems
have
emerged
as
potential
solutions
for
achieving
deep-tissue
imaging.
This
review
provides
a
comprehensive
analysis
various
laser-independent
systems,
with
particular
emphasis
on
those
based
resonance
energy
transfer
(RET),
chemically
induced
electron
exchange
luminescence
(CIEEL),
Cherenkov
radiation
(CRET).
aim
offer
theoretical
framework
development
novel
photodynamic
reassess
certain
previously
overlooked
(PSs).
On-demand
activation
of
prodrugs
represents
an
emerging
and
fast
developing
strategy
to
improve
the
therapeutic
index
certain
drugs.
However,
strategies
generate
protein-based
with
controllable
are
still
limited.
Here,
we
present
a
supramolecular
masking
that
enables
on-demand
macrocycle-masked
proteins
Food
Drug
Administration
(FDA)-approved
oral
Proteins
interest
were
engineered
incorporate
two
N-terminal
peptide
motifs,
which
dimerized
by
cucurbit[8]uril
(CB[8])
form
mask
sterically
blocks
functional
protein
interfaces,
inhibiting
interactions
targets
or
substrates.
The
inhibitory
effect
was
selectively
reversed
amantadine
memantine
restore
activity.
This
validated
across
various
classes,
including
antibodies,
cytokines,
enzymes.
Activation
CB[8]-masked
further
demonstrated
in
living
mice
via
FDA-approved
small
molecule
treatments.
Our
method
provided
for
selective
development
next-generation
therapeutics.
