Journal of the American Chemical Society,
Год журнала:
2024,
Номер
146(22), С. 15331 - 15344
Опубликована: Май 23, 2024
Within
the
context
of
Ni
photoredox
catalysis,
halogen
atom
photoelimination
from
has
emerged
as
a
fruitful
strategy
for
enabling
hydrogen
transfer
(HAT)-mediated
C(sp3)–H
functionalization.
Despite
numerous
synthetic
transformations
invoking
this
paradigm,
unified
mechanistic
hypothesis
that
is
consistent
with
experimental
findings
on
catalytic
systems
and
accounts
radical
formation
facile
C(sp2)–C(sp3)
bond
remains
elusive.
We
employ
kinetic
analysis,
organometallic
synthesis,
computational
investigations
to
decipher
mechanism
prototypical
Ni-catalyzed
photochemical
arylation
reaction.
Our
revise
previous
proposals,
first
by
examining
relevance
SET
EnT
processes
intermediates
relevant
HAT-based
investigation
highlights
ability
blue
light
promote
efficient
Ni–C(sp2)
homolysis
cationic
NiIII
reductive
elimination
bipyridine
NiII
complexes.
However
interesting,
rates
selectivities
these
do
not
account
productive
pathway.
Instead,
our
studies
support
involves
evolution
in
situ
generated
dihalide
intermediates,
capture
NiII(aryl)(halide)
resting
state,
key
C–C
NiIII.
Oxidative
addition
NiI,
opposed
Ni0,
rapid
NiIII/NiI
comproportionation
play
roles
process.
The
presented
herein
offer
fundamental
insight
into
reactivity
broader
catalysis.
Chemical Reviews,
Год журнала:
2024,
Номер
124(17), С. 10192 - 10280
Опубликована: Авг. 8, 2024
Radical
C–H
functionalization
represents
a
useful
means
of
streamlining
synthetic
routes
by
avoiding
substrate
preactivation
and
allowing
access
to
target
molecules
in
fewer
steps.
The
first-row
transition
metals
(Ti,
V,
Cr,
Mn,
Fe,
Co,
Ni,
Cu)
are
Earth-abundant
can
be
employed
regulate
radical
functionalization.
use
such
is
desirable
because
the
diverse
interaction
modes
between
metal
complexes
species
including
addition
center,
ligand
complexes,
substitution
single-electron
transfer
radicals
hydrogen
atom
noncovalent
complexes.
Such
interactions
could
improve
reactivity,
diversity,
selectivity
transformations
allow
for
more
challenging
reactions.
This
review
examines
achievements
this
promising
area
over
past
decade,
with
focus
on
state-of-the-art
while
also
discussing
existing
limitations
enormous
potential
high-value
regulated
these
metals.
aim
provide
reader
detailed
account
strategies
mechanisms
associated
Journal of the American Chemical Society,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 19, 2024
Copper
nanoclusters
(Cu
NCs)
characterized
by
their
well-defined
electronic
and
optical
properties
are
an
ideal
platform
for
organic
photocatalysis
exploring
atomic-level
behaviors.
However,
potential
as
greener,
efficient
catalysts
challenging
reactions
like
decarboxylative
oxygenation
under
mild
conditions
remains
unexplored.
Herein,
we
present
Cu
ACS Catalysis,
Год журнала:
2025,
Номер
15(10), С. 8303 - 8316
Опубликована: Май 2, 2025
A
practical
diastereoselective
photoredox
nickel-mediated
allylation
of
aliphatic
and
aromatic
aldehydes
with
Morita-Baylis-Hillman
(MBH)
acetates
is
reported
here.
The
reaction
proceeds
under
visible-light
irradiation
using
MBH
derivatives,
which
are
easily
prepared
from
inexpensive
available
starting
materials,
affording
functionalized
alcohols
as
a
single
diastereoisomer
(>20:1
for
the
syn
diastereoisomer).
popular
organic
dye
3DPAFIPN
used
photocatalyst
in
combination
Hantzsch
ester
presence
catalytic
amount
stable
nickel
complexes
o-phenanthroline
ligand.
shows
broad
scope,
avoiding
use
Ni(0),
well
stoichiometric
metal
reductants
such
Zn
Mn.
relevance
was
confirmed
by
products
rapid
access
to
α-methylene-β-lactones,
useful
intermediates
synthesis
natural
or
biologically
active
relevant
products.
DFT
calculations
suggest
that
allyl
acetate-coordinated
Ni(0)
species
plays
role
catalyst
cycle
operates
through
Ni(0)-Ni(II)-Ni(I)-Ni(0)
pathway.
European Journal of Organic Chemistry,
Год журнала:
2024,
Номер
27(11)
Опубликована: Фев. 7, 2024
Abstract
The
formation
of
C−N
bonds
is
a
vital
technique
in
organic
synthesis
for
creating
nitrogen‐containing
motifs,
which
has
extensive
uses
agrochemicals,
pharmaceuticals,
and
natural
products.
Significant
progress
been
made
constructing
using
transition
metal
catalysis.
Nevertheless,
utilizing
alkyl
substrates
the
C
sp3
−N
notable
challenge.
Synergistic
photoredox
copper
catalysis
have
proven
to
be
powerful
tool
tackle
this
development
research
domain
still
its
early
stages
owing
chemical
technical
complexities
catalytic
process.
This
review
attempts
summarize
in‐depth
mechanistic
understanding
photoredox/copper
dual
catalysed
coupling
reactions
taking
into
consideration
recently
reported
experimental
theoretical
studies.
Organic Letters,
Год журнала:
2024,
Номер
26(8), С. 1657 - 1661
Опубликована: Фев. 21, 2024
Excited-state
nickel-catalyzed
C–N
cross-coupling
of
aryl
bromides
with
sodium
azide
enables
the
synthesis
diarylamines
and
primary
anilines
under
mild
reaction
conditions.
The
oxidative
addition
electron-rich
low-valent
Ni
photochemical
conditions
is
endothermic.
Herein,
we
demonstrate
a
light-mediated
electronically
rich
that
yields
diarylamines,
while
electron-deficient
gives
access
to
at
room
temperature.
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
366(13), С. 2898 - 2918
Опубликована: Май 18, 2024
Abstract
Converting
any
desired
C−H
bond
to
the
intended
C−Z
in
a
given
organic
molecule
could
be
final
peak
of
functionalization
methodology.
Among
three
types
bonds,
ubiquitous
C(
sp
3
)−H
has
gained
particular
attention,
especially
last
two
decades.
There
are
different
ways
transform
bonds
into
bonds.
The
use
chlorine
radicals
is
one
these
methods
with
promising
future.
literature
review
shows
that
sources
have
been
used
for
chlorine,
including
chloride
ions
(HCl
or
salts),
coordinated
chlorides
(transition
metal
complexes),
and
(organochlorine
compounds).
However,
HCl
FeCl
most
attention
among
sources.
major
convert
from
radicals:
1)
oxidation
hydrogen
salts,
2)
photolysis
chloride,
3)
transition
insertion
C−Cl
This
summarizes
published
research
papers
on
functionalization.
Therefore,
chlorination
reactions
which
do
not
play
direct
role
cleavage
within
scope
this
review.
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
63(3)
Опубликована: Ноя. 13, 2023
Abstract
The
development
of
metal
complexes
that
function
as
both
photocatalyst
and
cross‐coupling
catalyst
remains
a
challenging
research
topic.
So
far,
progress
has
been
shown
in
palladium(0)
excited‐state
transition
catalysis
for
the
construction
carbon‐carbon
bonds
where
oxidative
addition
alkyl/aryl
halides
to
zero‐valent
palladium
(Pd
0
)
is
achievable
at
room
temperature.
In
contrast,
analogous
process
with
divalent
II
uphill
endothermic.
For
first
time,
we
report
can
act
light‐absorbing
species
undergoes
double
excitation
realize
carbon‐nitrogen
(C−N)
cross‐couplings
under
air.
Differently
substituted
aryl
be
applied
mild,
selective
amination
using
acetate
Density
functional
theory
studies
supported
by
mechanistic
investigations
provide
insight
into
reaction
mechanism.
Organic Letters,
Год журнала:
2023,
Номер
25(42), С. 7727 - 7732
Опубликована: Окт. 16, 2023
An
electron
donor-acceptor
(EDA)-triggered
hydrogen
atom
transfer
(HAT)
process
is
developed
for
the
efficient
generation
of
an
α-alkoxy
radical
from
cyclic
ethers
to
synthesize
exocyclic
alkenylated
with
exclusive
E-selectivity.
A
judiciously
chosen
pair
(DABCO
and
maleimide)
serves
as
desired
HAT
reagent
under
visible
light
irradiation
without
using
any
photocatalyst
or
peroxide.
wide
variety
substrates
were
explored
demonstrate
diverse
applicability
practical
viability
this
cross-dehydrogenative
transformation.
Detailed
mechanistic
studies
revealed
a
reaction
pathway
oxidative
environment.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(19)
Опубликована: Март 21, 2024
Abstract
We
report
on
the
synthesis
and
characterization
of
a
series
(mostly)
air‐stable
diorganyl
bis(pyridylimino)
isoindolide
(BPI)
aluminum
complexes
their
chemistry
upon
visible‐light
excitation.
The
redox
non‐innocent
BPI
pincer
ligand
allows
for
efficient
charge
transfer
homolytic
processes
title
compounds.
This
makes
them
universal
platform
generation
carbon‐centered
radicals.
photo‐induced
cleavage
Al−C
bonds
was
investigated
by
means
stationary
transient
UV/Vis
spectroscopy,
spin
trapping
experiments,
as
well
EPR
NMR
spectroscopy.
experimental
findings
were
supported
quantum
chemical
calculations.
Reactivity
studies
enabled
utilization
reactants
in
tin‐free
Giese‐type
reactions
carbonyl
alkylations
under
ambient
conditions,
which
both
indicated
radical‐polar
crossover
behavior.
A
deeper
understanding
physical
fundamentals
photochemical
process
provided,
furnishing
turn
new
strategy
to
control
reactivity
bench‐stable
organometallics.