International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(13), С. 6826 - 6826
Опубликована: Июнь 21, 2024
The
surface
functionalization
of
polymer-mediated
drug/gene
delivery
holds
immense
potential
for
disease
therapy.
However,
the
design
principles
underlying
polymers
remain
elusive.
In
this
study,
we
employed
computer
simulations
to
demonstrate
how
stiffness,
length,
density,
and
distribution
polymer
ligands
influence
their
penetration
ability
across
cell
membrane.
Our
revealed
that
stiffness
affects
transport
cargo
Increasing
can
promote
membrane,
particularly
larger
cargoes.
Furthermore,
appropriately
increasing
length
be
more
conducive
assisting
enter
lower
layer
Additionally,
on
also
plays
a
crucial
role
in
its
transport.
Specifically,
one-fourth
mode
stripy
distributions
exhibited
higher
ability,
cargoes
penetrating
These
findings
provide
biomimetic
inspiration
designing
high-efficiency
delivery.
Nanoscale,
Год журнала:
2023,
Номер
16(4), С. 1633 - 1649
Опубликована: Дек. 21, 2023
This
article
reviews
the
general
principles
and
strategies
for
constructing
protein-mineralized
nanomaterials
(PMNMs).
Subsequently,
progress
of
PMNMs
in
bioimaging,
anti-tumor,
anti-bacterial,
anti-inflammatory
therapies
is
summarized.
Reviews in Cardiovascular Medicine,
Год журнала:
2024,
Номер
25(11)
Опубликована: Ноя. 21, 2024
According
to
current
statistics,
the
mortality
rate
of
cardiovascular
diseases
remains
high,
with
coronary
artery
disease
being
primary
cause
death.
Despite
widespread
adoption
percutaneous
intervention
(PCI)
in
recent
years,
which
has
led
a
notable
decrease
myocardial
infarction
(MI),
pathological
cardiac
remodeling
and
heart
failure
that
follow
still
pose
significant
clinical
challenges.
Myocardial
ischemia-reperfusion
(MIR)
injury
represents
complex
pathophysiological
process,
involvement
macrophages
this
consistently
been
subject
focus.
Following
MIR,
infiltrate,
engulfing
tissue
debris
necrotic
cells,
secreting
pro-inflammatory
factors.
This
initial
response
is
crucial
for
clearing
damaged
tissue.
Subsequently,
(M1)
transition
an
anti-inflammatory
phenotype
(M2),
shift
essential
fibrosis
remodeling.
process
dynamic,
complex,
continuous.
To
enhance
understanding
review
elaborates
on
classification
functions
within
heart,
covering
research
signaling
pathways
involved
through
subsequent
MIR
fibrosis.
The
ultimate
aim
reduce
injury,
foster
conducive
environment
recovery,
improve
outcomes
MI
patients.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
14(1)
Опубликована: Дек. 1, 2024
Kidney
diseases
are
characterized
by
their
intricate
nature
and
complexity,
posing
significant
challenges
in
treatment
diagnosis.
Nanoparticles
(NPs),
which
can
be
further
classified
as
synthetic
biomimetic
NPs,
have
emerged
promising
candidates
for
treating
various
diseases.
In
recent
years,
the
development
of
engineered
nanotherapeutics
has
focused
on
targeting
damaged
tissues
serving
drug
delivery
vehicles.
Additionally,
these
NPs
shown
superior
sensitivity
specificity
diagnosis
imaging,
thus
providing
valuable
insights
early
detection
This
review
aims
to
focus
application
kidney
aspects
treatment,
diagnosis,
imaging.
Notably,
current
perspectives
evaluated,
provide
inspiration
future
research
directions,
encourage
clinical
this
field.
Angewandte Chemie,
Год журнала:
2024,
Номер
136(12)
Опубликована: Янв. 29, 2024
Abstract
Small
molecules,
including
therapeutic
drugs
and
tracer
play
a
vital
role
in
biological
processing,
disease
treatment
diagnosis,
have
inspired
various
nanobiotechnology
approaches
to
realize
their
function,
particularly
drug
delivery.
Desirable
features
of
delivery
system
for
functional
small
molecules
(FSMs)
include
high
biocompatibility,
loading
capacity,
simple
manufacturing
processes,
without
the
need
chemical
modification
FSM
itself.
Herein,
we
report
versatile
approach,
based
on
metal–phenolic‐mediated
assembly,
assembling
FSMs
into
nanoparticles
(i.e.,
FSM‐MPN
NPs)
under
aqueous
ambient
conditions.
We
demonstrate
anticancer
drugs,
latency
reversal
agents,
fluorophores
at
up
~80
%
that
is
mostly
facilitated
by
π
hydrophobic
interactions
between
nanoparticle
components.
Secondary
engineering
involving
coating
with
polyphenol–antibody
thin
film
or
sequential
co‐loading
multiple
enables
cancer
cell
targeting
combination
delivery,
respectively.
Incorporating
NPs
visualization
biodistribution
different
time
points,
revealing
most
these
are
retained
kidney
heart
24
h
post
intravenous
administration.
This
work
provides
viable
pathway
rational
design
molecule
platforms
diverse
applications.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(13), С. 6826 - 6826
Опубликована: Июнь 21, 2024
The
surface
functionalization
of
polymer-mediated
drug/gene
delivery
holds
immense
potential
for
disease
therapy.
However,
the
design
principles
underlying
polymers
remain
elusive.
In
this
study,
we
employed
computer
simulations
to
demonstrate
how
stiffness,
length,
density,
and
distribution
polymer
ligands
influence
their
penetration
ability
across
cell
membrane.
Our
revealed
that
stiffness
affects
transport
cargo
Increasing
can
promote
membrane,
particularly
larger
cargoes.
Furthermore,
appropriately
increasing
length
be
more
conducive
assisting
enter
lower
layer
Additionally,
on
also
plays
a
crucial
role
in
its
transport.
Specifically,
one-fourth
mode
stripy
distributions
exhibited
higher
ability,
cargoes
penetrating
These
findings
provide
biomimetic
inspiration
designing
high-efficiency
delivery.
