Angelica sinensis polysaccharide as potential protectants against recurrent spontaneous abortion: focus on autophagy regulation

Frontiers in Medicine, Год журнала: 2025, Номер 12

Опубликована: Янв. 15, 2025

Recurrent spontaneous abortion (RSA) represents a significant clinical challenge, with its underlying mechanisms yet to be fully elucidated. Despite advances in understanding, the precise pathophysiology driving RSA remains unclear. Angelica sinensis, traditional herbal remedy, is frequently used as an adjunctive treatment for miscarriage. However, it uncertain whether primary active component, sinensis polysaccharide (ASP), plays definitive role therapeutic effects. The specific function and mechanism of ASP context require further investigation. In this study, we sought evaluate autophagy levels at maternal-fetal interface patients mouse model treated ASP, complemented by comprehensive metabolomic analysis. Autophagy flux decidua was compared between eight healthy pregnant women. Additionally, changes were assessed following treatment, embryos placental tissues collected subsequent profiling. Our results revealed reduction Beclin 1 protein normal pregnancy group. Conversely, restored autophagy-related expression, including ATG7, ATG16L, 1, higher than those observed untreated Metabolomic analyses identified phosphatidylethanolamine ASP-treated control groups, differential metabolites enriched pathways related glycolysis/gluconeogenesis, glycerolipid metabolism, glycine, serine, threonine metabolism. Functional assays that enhances trophoblast cell proliferation, migration, invasion. summary, our findings demonstrate diminished activity patients, while appears restore regulate key metabolic pathways, glycolysis/gluconeogenesis. These provide new insights into protective RSA, suggesting potential intervention condition.

Язык: Английский

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Therapeutic Effects of Natural Products in the Treatment of Chronic Diseases: The Role in Regulating KEAP1–NRF2 Pathway

The American Journal of Chinese Medicine, Год журнала: 2025, Номер unknown, С. 1 - 30

Опубликована: Янв. 29, 2025

Oxidative stress represents a pivotal mechanism in the pathogenesis of numerous chronic diseases. The Kelch-like ECH-associated protein 1–transcription factor NF-E2 p45-related 2 (KEAP1–NRF2) pathway plays crucial role maintaining redox homeostasis and regulating multitude biological processes such as inflammation, homeostasis, metabolic homeostasis. In this paper, we present findings recent studies on KEAP1–NRF2 pathway, which have revealed that it is aberrantly regulated induces oxidative injury variety diseases neurodegenerative diseases, cardiovascular respiratory digestive cancer. Given evidence, targeting highly promising avenue for developing therapeutic strategies thus development appropriate based NRF2 has emerged significant area research interest. This paper highlights an overview current to modulate KEAP1–NRF2, well advances use natural compounds traditional Chinese medicine, with view providing meaningful guidelines drug discovery KEAP1–NRF2. Additionally, discusses challenges associated harnessing target.

Язык: Английский

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Advancing brain injury treatment and neuroprotection with ligustilide: Mechanisms and therapeutic potential

Brain Hemorrhages, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

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Isolation, synthesis, mechanism of action, and pharmacological activities of bisabolangelone and related bisabolenoids

European Journal of Medicinal Chemistry Reports, Год журнала: 2025, Номер 14, С. 100277 - 100277

Опубликована: Май 26, 2025

Язык: Английский

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Effect of different cooking methods on saponin content and hematopoietic effects of Panax notoginseng-steamed chicken on mice

Journal of Ethnopharmacology, Год журнала: 2023, Номер 311, С. 116434 - 116434

Опубликована: Апрель 6, 2023

Panax notoginseng-steamed chicken (PNSC) is a medicinal food with ethnic characteristics developed by the Miao group in southeast of Yunnan Province, China. PNSC has been eaten for hundreds years, and its tonic effect widely recognized people. However, cooking conditions scientific connotation toning blood supplementing deficiency are also lack in-depth analysis.To optimize to explore anemia-improving effects.The ratio P. notoginseng (PN) steaming time were systematically altered, was optimized response surface method. By establishing animal models postpartum blood-deficiency anemia, acute hemorrhagic anemia myelosuppressive replenishing explored, mechanism on revealed immunoblotting analyses histopathological sectioning.The optimal processing included 100:5 5.5 h. The amounts polysaccharides (PNPS), total protein blood-enriching saponins 44.3 mg/g, 2.48% 2.04%, respectively. Freeze-dried powder steamed soup (FPSC) found promote recovery routine factors organ indexes three activate JAK2-STAT5 signaling pathway, induce phosphorylation JAK2 STAT5 normalize secretion hematopoietic regulators EPO, IL-3, TNF-α.FPSC improves symptoms mice, it plays role tonifying activating pathway altering expression hematopoiesis-related factors.

Язык: Английский

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Origin Intelligent Identification of Angelica sinensis Using Machine Vision and Deep Learning

Agriculture, Год журнала: 2023, Номер 13(9), С. 1744 - 1744

Опубликована: Сен. 2, 2023

The accurate identification of the origin Chinese medicinal materials is crucial for orderly management market and clinical drug usage. In this study, a deep learning-based algorithm combined with machine vision was developed to automatically identify Angelica sinensis (A. sinensis) from eight areas including 1859 samples. effects different datasets, learning rates, solver algorithms, training epochs batch sizes on performance model were evaluated. optimized hyperparameters dataset 4, rate 0.001, rmsprop, 6, 20, which showed highest accuracy in process. Compared support vector (SVM), K-nearest neighbors (KNN) decision tree, could significantly improve prediction show better robustness generalization performance. achieved accuracy, precision, recall F1_Score values, 99.55%, 99.41%, 99.49% 99.44%, respectively. These results that can effectively A. sinensis.

Язык: Английский

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Role of Danggui Buxue Decoction for the prevention and treatment of cardiovascular and pulmonary diseases.

PubMed, Год журнала: 2023, Номер 48(10), С. 1479 - 1493

Опубликована: Окт. 28, 2023

Cardiovascular and pulmonary diseases have become the major disease endangering people's physical mental health because of its high morbidity mortality. Danggui Buxue Decoction, a noteworthy classical prescription, is composed astragali radix angelicae sinensis at ratio 5꞉1. It prescription for tonifying both vital energy blood has effect dredging collaterals. Its main active components, such as polysaccharides, saponins, flavonoids volatile oils, good effects on antioxidation, inflammation regulation, immune regulation promotion circulation. Decoction can improve myocardial ischemia-reperfusion injury heart failure, relieve symptoms diabetic cardiomyopathy, inhibit fibrosis, protect lung fight against cancer other cardiopulmonary diseases. Preclinical studies showed that this oxidative stress, regulate autophagy enhance function through multi-target pathways. Reviewing effective pharmacological action mechanism, clinical application are helpful to provide comprehensive information in prevention treatment cardiovascular

Язык: Английский

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Improving Chuanxiong Rhizoma quality standards using an effect-constituent index based bioassay

Journal of Pharmaceutical and Biomedical Analysis, Год журнала: 2023, Номер 233, С. 115455 - 115455

Опубликована: Май 15, 2023

Язык: Английский

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Senkyunolide B exhibits broad‐spectrum antifungal activity against plant and human pathogenic fungi via inhibiting spore germination and destroying the mature biofilm

Pest Management Science, Год журнала: 2023, Номер 79(12), С. 4952 - 4963

Опубликована: Авг. 2, 2023

Aspergillus infection seriously jeopardizes the health and safety of life immunocompromised patients. The emergences antifungal resistance highlight a demand to find new effective drugs. Angelica sinensis is medicine-food herb phthalides are its characteristic components. A few have been reported display satisfactory activities against plant pathogenic fungi. However, structure-activity relationships action mechanism remain be further explored elucidated.The five natural four artificial analogs were investigated, their preliminarily elucidated in current study. benzene ring moiety played an essential role activities; oxygen-containing substituents on obviously impacted activities, free hydroxyl was favorable activity. Typical phthalide senkyunolide B (SENB) exhibited broad human fungi, especially, fumigatus. SENB affected spore germination hyphae growth fumigatus via down-regulating phosphatidylinositol-PKC-calcineurin axis expression ENG genes. Moreover, disturbed oxidation-reduction process destroy mature biofilms. In vivo experiments indicated significantly prolonged survival decreased fungal burden mouse model invasive pulmonary aspergillosis.Phthalides could considered as valuable leads for development drug cure disease. © 2023 Society Chemical Industry.

Язык: Английский

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Integrated metabolomics and network pharmacology to reveal the lipid‐lowering mechanisms of Qizha Shuangye granules in hyperlipidemic rats

Journal of the Science of Food and Agriculture, Год журнала: 2023, Номер 104(6), С. 3265 - 3274

Опубликована: Дек. 13, 2023

Qizha Shuangye granules (QSG) comprise six traditional Chinese herbal medicines (TCHMs), which have a long history of treating hyperlipidemia (HLP) in China. This study aimed to evaluate the potential lipid-lowering effects QSG an HLP rat model and investigate possible mechanisms. The was induced by high-fat diet. Lipid-related indicators serum were detected. Serum liver metabolites investigated using liquid chromatography-mass spectrometry-based metabolomics approach. A herb-compound-target-metabolite (H-C-T-M) network further constructed reveal molecular mechanism alleviate HLP.

Язык: Английский

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