Chemical Engineering Journal, Год журнала: 2023, Номер 472, С. 144599 - 144599
Опубликована: Июль 17, 2023
Язык: Английский
Chemical Reviews, Год журнала: 2022, Номер 123(9), С. 5262 - 5296
Опубликована: Дек. 6, 2022
Chemoenzymatic catalysis, by definition, involves the merging of sequential reactions using both chemocatalysis and biocatalysis, typically in a single reaction vessel. A major challenge, solution to which, however, is associated with numerous advantages, run such one-pot processes water: majority enzyme-catalyzed take place water as Nature's medium, thus enabling broad synthetic diversity when due option use virtually all types enzymes. Furthermore, cheap, abundantly available, environmentally friendly, making it, principle, an ideal medium. On other hand, most routinely performed today organic solvents (which might deactivate enzymes), appearing make it difficult combine biocatalysis toward cascades water. Several creative approaches solutions that enable combinations chemo- be realized applied problems are presented herein, reflecting state-of-the-art this blossoming field. Coverage has been sectioned into three parts, after introductory remarks: (1) Chapter 2 focuses on historical developments initiated area research; (2) 3 describes key post-initial discoveries have advanced field; (3) 4 highlights latest achievements provide attractive main question compatibility between (used predominantly aqueous media) (that remains solvents), Chapters covering mainly literature from ca. 2018 present. 5 6 brief overview where field stands, challenges lie ahead, ultimately, prognosis looking future chemoenzymatic catalysis synthesis.
Язык: Английский
Процитировано
100
Deleted Journal, Год журнала: 2025, Номер 2(1)
Опубликована: Янв. 2, 2025
Abstract The field of chronic wound care has been rapidly evolving. With a market size for wounds in billions USD, this is not an insignificant area to encourage more sustainable practices and processes. sourcing starting materials dressings from renewable resources the first crucial step ensuring that environmental impact minimized. Next important choice select methodologies accordance with principles green chemistry. This involves utilizing solvents as reaction media chemical processes preparing dressing materials. In many cases, like production hydrogels, crosslinking reagents are often employed. These can be, general, easily replaced by enzymes peroxidases, tyrosinases sortases. Process intensification strategies have emerged powerful approach ensure economy sustainability at large scale. Use microwave radiations ultrasonication instead heat accelerate rates helps cases inject wounds. review attempts highlight ongoing efforts future possibilities development cost-effective methods. Graphical
Язык: Английский
Процитировано
3
ACS Catalysis, Год журнала: 2023, Номер 13(8), С. 5584 - 5598
Опубликована: Апрель 10, 2023
Amine transaminases constitute an important class of enzymes for the synthesis chiral amines, which are commonly used as building blocks in pharmaceutical compounds and fine chemicals. Over past decade, developments enzyme discovery process protein engineering have advanced use organic synthesis. Recent advances enzymatic cascade attracted attention due to efficient environmentally friendly routes synthesize amines. Enzymatic cascades can reduce traditional multistep enabled generation products from cheap starting materials. This review focuses on amine by chemoenzymatic utilizing transaminases.
Язык: Английский
Процитировано
23
Organic Process Research & Development, Год журнала: 2024, Номер 28(4), С. 816 - 830
Опубликована: Март 14, 2024
From the context of sustainability, contemporary synthetic organic chemistry practices require significant transformation, as indicated by various sustainability matrices like atom economy, process mass intensity (PMI), E-factor, and DOZN. These factors have evidently unveiled inherent inefficiencies intrinsic to conventional protocols identified solvents principal causative agent. In response, utilization water a primary reaction medium for transformations has emerged an appealing alternative. This approach flourished with emergence micellar catalysis, where amphiphilic molecules alter bulk aqueous medium's solvation properties promote desired chemical transformation under milder sustainable conditions. After 2010, this technology gained considerable momentum established foundational framework performing reactions conditions, consequently mitigating dependency on hazardous solvents. perspective, recent advances in field catalysis will be discussed industrial applications, along future directions challenges associated regime.
Язык: Английский
Процитировано
10
Green Chemistry, Год журнала: 2023, Номер 26(2), С. 739 - 752
Опубликована: Дек. 11, 2023
Some of the latest technological developments involving chemistry in water are discussed.
Язык: Английский
Процитировано
21
Green Chemistry, Год журнала: 2023, Номер 25(16), С. 6092 - 6107
Опубликована: Янв. 1, 2023
Stages of the penetration catalytic technology and necessity for fruitful collaboration.
Язык: Английский
Процитировано
19
Current Opinion in Colloid & Interface Science, Год журнала: 2023, Номер 65, С. 101691 - 101691
Опубликована: Март 17, 2023
Язык: Английский
Процитировано
17
Organic Process Research & Development, Год журнала: 2024, Номер 28(4), С. 978 - 1002
Опубликована: Март 15, 2024
Despite the reported successes and advantages involving use of amphiphilic surfactants, most notably TPGS-750-M, to enable a multitude synthetic transformations be conducted in water, implementation this methodology within pharmaceutical industry has been relatively limited. In paper, we will disclose key results learnings from multicompany collaboration focused on reproducibility study some commonly used reaction types industry, specifically amidation, SNAr, nitro reduction, reductive amination, multiple Pd-catalyzed water. The presentation not just originally TPGS-750-M conditions but also under water-only control with three different as well both small (i.e., ≤500 mg) mid (∼10 g) scales.
Язык: Английский
Процитировано
7
ACS Catalysis, Год журнала: 2023, Номер 13(5), С. 3179 - 3186
Опубликована: Фев. 17, 2023
A protocol has been developed that not only simplifies the preparation of nanoparticles (NPs) containing ppm levels ligated palladium affect heterogeneous catalysis but also ensures they afford products cross-couplings reproducibly due to freshly prepared nature each reagent. Four different types couplings are studied: Suzuki-Miyaura, Sonogashira, Mizoroki-Heck, and Negishi reactions, all performed under mild aqueous micellar conditions. The simplified process relies on initial formation stable, storable Pd- ligand-free NPs, which is then added appropriate amount Pd(OAc)2 ligand-matched desired type coupling, in water.
Язык: Английский
Процитировано
15
Green Chemistry, Год журнала: 2024, Номер 26(11), С. 6666 - 6674
Опубликована: Янв. 1, 2024
The synthesis of enantiopure chiral halogenated aryl alcohols by ketoreductases was conducted in an aqueous micellar solution formed TPGS-750-M, achieving remarkable yields and enantioselectivities under high concentration.
Язык: Английский
Процитировано
4