The surface modification of the silica-coated magnetic nanoparticles and their application in molecular diagnostics of virus infection
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Июнь 23, 2024
The
study
presents
a
series
of
examples
magnetic
nanoparticle
systems
designed
for
the
diagnosis
viral
diseases.
In
this
interdisciplinary
work,
we
describe
one
most
comprehensive
synthetic
approaches
preparation
and
functionalization
smart
rapid
effective
RT-PCR
diagnostics
isolation
RNA.
Twelve
different
organic
ligands
inorganic
porous
silica
were
used
surface
Fe3O4
core
to
increase
number
active
centres
efficient
RNA
binding
from
human
swab
samples.
Different
with
common
beads
characterized
by
HRTEM,
SEM,
FT-IR,
XRD,
XPS
measurements.
We
demonstrate
application
fundamental
models
modified
fit
experimental
zero-field
cooling
magnetization
data.
discuss
influence
shell
parameters
(morphology,
thickness,
ligands)
on
overall
performance
systems.
prepared
nanoparticles
tested
tissue
samples
infected
hepatitis
E
virus-HEV
biofluid
SARS-CoV-2
positive
patients.
efficiency
was
quantified
RT-qPCR
method.
Язык: Английский
Recent Advances in the Use of 2‐Aminobenzyl Alcohols in the Synthesis of Quinolines, Quinazolines and Other N‐Heterocycles
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
366(10), С. 2142 - 2164
Опубликована: Янв. 17, 2024
Abstract
N‐Heterocyclic
compounds,
in
particular,
quinolines
and
quinazolines
are
frequently
used
medicinal
chemistry.
Therefore,
the
direct
clean
synthesis
of
these
valuable
scaffolds
has
been
a
great
interest
for
many
years.
2‐Aminobenzyl
alcohols
as
an
alternative
reactant
instead
unstable
expensive
2‐aminobenzaldehydes
can
be
construction
N‐fused
heterocycles
including
quinolines,
quinazolines,
oxazines,
thiazines,
selenazines,
imidazoles,
diazepines,
etc.
In
this
review
article,
we
have
discussed
recent
developments
use
2‐aminobenzyl
diverse
heterocycles.
Язык: Английский
Facile Synthesis of 2-Substituted Quinazolines via Ruthenium(II)-Catalyzed Acceptorless Dehydrogenative Coupling
Current Organic Chemistry,
Год журнала:
2024,
Номер
28(4), С. 305 - 318
Опубликована: Фев. 1, 2024
Abstract::
This
study
aims
to
develop
a
practical
and
facile
one-pot
synthesis
of
2-
substituted
quinazolines.
Using
commercially
available
structurally
simple
ruthenium(
II)
complex
as
the
catalyst
synthesize
series
quinazoline
derivatives
via
acceptorless
dehydrogenative
coupling.
The
mechanism
this
reaction
was
explored
by
control
DFT
calculation.
protocol
offers
access
diverse
array
(52
examples)
in
moderate
excellent
yields
(29%-98%).
In
summary,
we
have
developed
an
efficient
ruthenium
(II)-catalyzed
ADC
under
air
atmosphere.
only
produces
hydrogen
water
by-products,
serving
sustainable
atom-efficient
synthetic
approach.
Язык: Английский
Single atom catalysts enable quasi-homogeneous synthesis of quinazoline
Chemical Engineering Journal,
Год журнала:
2023,
Номер
474, С. 145651 - 145651
Опубликована: Авг. 25, 2023
Язык: Английский
Copper-catalyzed synthesis of quinazolines via cascade cyclization/hydrodehalogenation
New Journal of Chemistry,
Год журнала:
2023,
Номер
47(19), С. 9377 - 9382
Опубликована: Янв. 1, 2023
We
report
a
Cu(
i
)-catalyzed
synthesis
of
quinazolines
via
cascade
cyclization/hydrodehalogenation
by
using
acetamide
as
nitrogen
source
and
H
2
O
hydrogen
source.
Язык: Английский
Interweaved needle‐shaped α‐Ni(OH)2 nanoparticles adorned on graphene oxide: A new class of heterogeneous catalysts for α‐alkylation of ketones and synthesis of azines
Applied Organometallic Chemistry,
Год журнала:
2023,
Номер
38(2)
Опубликована: Дек. 13, 2023
A
simple
approach
for
synthesizing
needle‐shaped
α
‐Ni(OH)
2
nanoparticles
adorned
on
graphene
oxide,
‐GO,
is
described.
The
nanocomposite
was
isolated
as
an
air‐stable
black
powder
and
characterized
by
various
instrumental
techniques.
interweaved
morphology
the
average
particle
diameter
~7
nm
of
were
ascertained
Field
Emission
Scanning
Electron
Microscopy
(FESEM)
Transmission
(TEM)
analysis,
respectively.
catalytic
potential
scrutinized
in
synthesis
monosubstituted
ketones
via
a
hydrogen
autotransfer
strategy
azines
dehydrogenative
pathway.
products
both
reactions
excellent
yields
nuclear
magnetic
resonance
(NMR)
spectroscopy.
‐GO
could
be
segregated
recycled
up
to
five
cycles.
operational
simplicity,
broad
substrate
scope,
non‐toxic
side
products,
recyclability,
superior
catalyst
are
some
remarkable
features
this
protocol.
Язык: Английский
Creation of a Highly Active Small Cu‐Based Catalyst Derived from Copper Aluminium Layered Double Hydroxide Supported on α‐Al2O3 for Acceptorless Alcohol Dehydrogenation
Chemistry - An Asian Journal,
Год журнала:
2023,
Номер
18(21)
Опубликована: Сен. 27, 2023
A
highly
dispersed
carbonate-intercalated
Cu2+
-Al3+
layered
double
hydroxide
(CuAl
LDH)
was
created
on
an
unreactive
α-Al2
O3
surface
LDH@α-Al2
)
via
a
simple
coprecipitation
method
of
and
Al3+
under
alkaline
conditions
in
the
presence
.
reducible
CuO
nanoparticles
generated,
accompanied
by
formation
CuAl2
O4
(CuAlO@α-Al2
after
calcination
at
1073
K
air,
as
confirmed
powder
X-ray
diffraction
(XRD)
Cu
K-edge
absorption
near
edge
structure
(XANES).
The
structural
changes
during
progressive
heating
process
were
monitored
using
in-situ
temperature-programmed
synchrotron
XRD
(tp-SXRD).
CuAl
completely
disappeared
473
K,
or
phases
began
to
appear
823
1023
respectively.
Our
synthesised
CuAlO@α-Al2
catalyst
active
for
acceptorless
dehydrogenation
benzylic,
aliphatic,
cyclic
aliphatic
alcohols;
TON
based
amount
increased
163
from
3.3
unsupported
CuAlO
1-phenylethanol
dehydrogenation.
results
suggested
that
Cu0
obtained
reduction
matrix
reaction
without
separate
procedure
acted
catalytically
species.
Язык: Английский