The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 6, 2025
A
water-controlled
geminal
phosphinoylation
of
enaminones
with
H-phosphine
oxides
has
been
established
through
AlCl3-mediated
C-N
bond
cleavage
in
this
work,
which
provides
a
novel
strategy
for
accessing
various
hydroxy
and
diphosphinoyl
products
3a
4a
high
yields.
The
transformation
features
excellent
functional
group
tolerance,
operational
simplicity,
atom
economy,
is
amenable
complex
molecule
skeletons.
Preliminary
mechanism
studies
suggest
the
conversion
from
to
involve
elimination
hydroxyl
group,
water
temperature
plays
critical
role
influencing
reaction
pathway
product
selectivity.
This
research
significant
value
functionalization
enaminones.
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
90(2), С. 984 - 993
Опубликована: Янв. 7, 2025
A
facile
copper-catalyzed,
base-controlled
cyclization
reaction
has
been
developed
for
the
synthesis
of
9-membered
cycloalkyne
and
6-membered
heterocycle
sultams
under
mild
conditions.
This
protocol
utilizes
a
copper-catalyzed
intramolecular
A3
(alkyne–aldehyde–amine)
coupling
to
efficiently
synthesize
in
yields
up
90%.
Alternatively,
by
substituting
NaHCO3
with
DBU,
achieves
selective
deprotection
N-propargyl
group,
thereby
facilitating
formation
heterocyclic
sultams,
also
high
yields.
Molecules,
Год журнала:
2025,
Номер
30(2), С. 350 - 350
Опубликована: Янв. 16, 2025
In
this
study,
we
present
the
HOAc-catalyzed
selective
cleavage
of
C=C
double
bond
enaminones,
enabling
formation
a
new
C–N
and
C=N
for
one-pot
synthesis
2-substituted
3,4-dihydroquinazolines
directly
from
ynones
2-(aminomethyl)anilines.
This
method
operates
in
ethanol
under
transition-metal-free
oxidant-free
conditions,
offering
sustainable
efficient
approach
with
broad
functional
group
tolerance.
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 6, 2025
A
novel
approach
to
the
synthesis
of
β-CF3
β-aminoenones
by
organic
amine
base-catalyzed
reaction
CF3-iminopropargylic
alcohols
with
carboxylic
acids
is
reported.
The
advantages
protocol
are
ease
operation,
available
starting
materials,
and
simple
tertiary
catalysts.
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 6, 2025
A
water-controlled
geminal
phosphinoylation
of
enaminones
with
H-phosphine
oxides
has
been
established
through
AlCl3-mediated
C-N
bond
cleavage
in
this
work,
which
provides
a
novel
strategy
for
accessing
various
hydroxy
and
diphosphinoyl
products
3a
4a
high
yields.
The
transformation
features
excellent
functional
group
tolerance,
operational
simplicity,
atom
economy,
is
amenable
complex
molecule
skeletons.
Preliminary
mechanism
studies
suggest
the
conversion
from
to
involve
elimination
hydroxyl
group,
water
temperature
plays
critical
role
influencing
reaction
pathway
product
selectivity.
This
research
significant
value
functionalization
enaminones.
