Site-selective direct nitration of 2H-indazoles: easy access to 7-nitroindazoles

Chemical Communications, Год журнала: 2024, Номер 60(30), С. 4076 - 4079

Опубликована: Янв. 1, 2024

This work discloses a new methodology for the site-selective direct installation of nitro group at benzene ring 2 H -indazoles with excellent selectivity towards synthesis 7-nitroindazole derivatives.

Язык: Английский

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An efficient and simple approach for synthesizing indazole compounds using palladium-catalyzed Suzuki–Miyaura cross-coupling

RSC Advances, Год журнала: 2024, Номер 14(36), С. 26494 - 26504

Опубликована: Янв. 1, 2024

Suzuki–Miyaura cross-coupling, density functional theory, and auto-docking investigations were used to determine the effectiveness stability of indazole derivatives.

Язык: Английский

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The γ-Valerolactone (GVL) as Innoxious Reaction Media for the Synthesis of 2-Aryl-2H-Indazoles via C-N and N-N Bond Formation under Cu(I)-Catalyzed Ligand and Base Free Conditions

Polycyclic aromatic compounds, Год журнала: 2023, Номер 44(7), С. 4832 - 4843

Опубликована: Сен. 13, 2023

AbstractAn efficient method for N-arylation and N-N bond formation has been developed using an innoxious reaction medium, γ-valerolactone (GVL), as both a solvent ligand. The strategy involves utilizing CuI catalyst under conditions free of external ligands bases. Various aldehyde amine derivatives with different functional groups were investigated, resulting in the production 2-aryl-2H-indazole compounds yields ranging from 75% to 93%. This study highlights effectiveness GVL, derived biomass, medium ligand multicomponent reaction.Keywords: C-N formationN-N formationCu(I)-catalysis2H-indazolemulticomponent AcknowledgementsCCM appreciates Science Engineering Research Board (SERB), New Delhi financial support form research grants [CRG/2020/004509 ECR/2016/000337]. KK grateful Ministry Education (MoE), fellowship support. authors extend their appreciation Researchers Supporting Project number [RSP2023R381], King Saud University, Riyadh, Saudi Arabia.Author contributionsThe manuscript was written through contributions all have given approval final version manuscript.Disclosure statementNo potential conflict interest reported by author(s).

Язык: Английский

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MICROWAVE-ASSISTED FUNCTIONALIZATION OF INDAZOLES: AN OVERVIEW

RASAYAN Journal of Chemistry, Год журнала: 2023, Номер 16(03), С. 1560 - 1574

Опубликована: Янв. 1, 2023

Indazole-based heterocyclic compounds possessing significant medicinal properties form the basis of developing several pharmaceuticals.Microwave-assisted organic synthesis is one most effective and promising techniques from perspective green chemistry, as it increases reaction rates yields while decreasing wasteful byproducts.Functionalization indazole derivatives under microwave irradiation achieving tremendous interest in recent times.Various cross-coupling reactions are generally utilized during microwave-assisted functionalization indazoles.This review article chronologically describes different types indazoles assisted by with up-to-date literature coverage.

Язык: Английский

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Five-membered ring systems: with more than one N atom

Progress in heterocyclic chemistry, Год журнала: 2023, Номер unknown, С. 281 - 332

Опубликована: Янв. 1, 2023

Язык: Английский

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