Synthesis of 3-sulfonylisoindolin-1-ones from olefinic amides and sodium sulfinates via electrooxidative tandem cyclization

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(29), С. 5897 - 5901

Опубликована: Янв. 1, 2024

Sulfonyl groups are motifs that widely found in biologically active compounds and drug molecules, many isolated natural products as well pharmaceuticals contain sulfonyl groups. Herein, we present the synthesis of sulfonyl-substituted isoindolones by a electrochemical oxidative radical cascade cycloaddition reaction olefinic amides with sodium sulfite under oxidant- catalyst-free conditions. Various sulfinates were compatible gave desired yields up to 99%.

Язык: Английский

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Visible-Light-Induced C(sp³)-H Activation for Minisci Alkylation of Pyrimidines Using CHCl₃ as Radical Source and Oxidant

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 14, 2025

A highly efficient Minisci reaction of pyrimidines with alkyl radical generated from visible-light-induced activation simple C(sp3)-H feedstocks such as (cyclo)alkanes, ethers, alcohols, esters, and amides is reported. mechanistic study revealed that was via hydrogen atom transfer (HAT) dichloromethyl (·CHCl2), which by photoreduction chloroform.

Язык: Английский

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Recent progress in the application of amidines for the synthesis of N-heterocyclic compounds

Monatshefte für Chemie - Chemical Monthly, Год журнала: 2024, Номер 155(5), С. 419 - 439

Опубликована: Март 6, 2024

Язык: Английский

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Six-membered ring systems: Diazines and benzo derivatives

Progress in heterocyclic chemistry, Год журнала: 2024, Номер unknown, С. 355 - 393

Опубликована: Янв. 1, 2024

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