The
study
introduces
a
previously
unidentified
method
for
amide
bond
formation
that
addresses
several
limitations
of
conventional
approaches.
It
uses
the
β-silyl
alkynoate
molecule,
where
alkynyl
group
activates
ester
efficient
formation,
while
bulky
TIPS
(triisopropylsilane)
prevents
unwanted
1,4-addition
reactions.
This
approach
exhibits
high
chemoselectivity
amines,
making
compatible
with
wide
range
substrates,
including
secondary
and
targets
specific
ε-amino
lysine
among
native
amino
ester’s
derivatives.
maintains
stereochemistry
during
removal,
allowing
versatile
platform
postsynthesis
modifications
such
as
click
reactions
peptide-drug
conjugations.
These
advancements
hold
substantial
promise
pharmaceutical
development
peptide
engineering,
opening
avenues
research
applications.
Langmuir,
Год журнала:
2024,
Номер
40(24), С. 12381 - 12393
Опубликована: Июнь 5, 2024
A
gel
that
exhibits
intrinsically
multiple-responsive
behavior
was
prepared
from
an
oligopeptide
and
studied.
ACP(65-74)
is
active
decapeptide
fragment
of
acyl
carrier
protein.
We
investigated
3%
w/v
ACP(65-74)-NH2
self-healing
physical
gels
in
water,
glycerol
carbonate
(GC),
their
mixtures.
The
morphology
by
optical,
birefringence,
confocal
laser
scanning
microscopy,
circular
dichroism,
Fourier
transform
infrared,
fluorescence
spectroscopy
experiments.
found
all
samples
possess
pH
responsiveness
with
fully
reversible
sol-to-gel
transitions.
rheological
properties
depend
on
the
temperature
solvent
composition.
dependence
water
shows
a
peculiar
similar
to
thermoresponsive
polymer
solutions.
results
reveal
presence
several
β-sheet
structures
amyloid
aggregates,
offering
valuable
insights
into
fibrillation
mechanism
amyloids
different
media.
As
sustainable
and
eco-friendly
replacements
to
conventional
paper,
rewritable
paper
is
a
very
attractive
alternative
for
communication,
information
circulation,
storage.
Development
made
using
chromogenic
materials
that
change
its
color
in
presence
of
external
stimuli.
However,
the
new
techniques
have
faced
several
major
challenges
including
feasible
operational
method,
approach.
Herein,
simple,
convenient,
strategy
described
preparation
substrate,
multi
colored
ink
efficient
use
writing,
painting
or
printing
purpose.
In
addition,
writing
with
"invisible
ink"
on
can
be
realized
potential
anti-counterfeiting
application.
The
written,
painted,
printed
substrate
easily
erased
an
aqueous
solution.
Thus,
original
retrieved
reused
multiple
times.
Besides,
written
retained
prolonged
time
at
ambient
conditions.
Overall,
this
approach
shows
as
prototype
multicolor
writing/painting
application,
offering
solution
reducing
waste
promoting
environmental
stewardship.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(19), С. 5422 - 5428
Опубликована: Янв. 1, 2024
A
new
electron-deficient
aromatic-based
coupling
reagent,
tetrafluorophthalonitrile
(TFPN),
designed
according
to
the
concept
of
dual
reagents,
is
developed
facilitate
amide
and
peptide
bond
formation
in
a
one-pot,
two-step
manner.
The
study
introduces
a
previously
unidentified
method
for
amide
bond
formation
that
addresses
several
limitations
of
conventional
approaches.
It
uses
the
β-silyl
alkynoate
molecule,
where
alkynyl
group
activates
ester
efficient
formation,
while
bulky
TIPS
(triisopropylsilane)
prevents
unwanted
1,4-addition
reactions.
This
approach
exhibits
high
chemoselectivity
amines,
making
compatible
with
wide
range
substrates,
including
secondary
and
targets
specific
ε-amino
lysine
among
native
amino
ester’s
derivatives.
maintains
stereochemistry
during
removal,
allowing
versatile
platform
postsynthesis
modifications
such
as
click
reactions
peptide-drug
conjugations.
These
advancements
hold
substantial
promise
pharmaceutical
development
peptide
engineering,
opening
avenues
research
applications.
