Organic Letters,
Год журнала:
2024,
Номер
26(43), С. 9357 - 9362
Опубликована: Окт. 23, 2024
In
this
Letter,
we
described
a
visible-light-induced
switchable
synthesis
of
nonaromatic
and
aromatic
sulfonyl
heterocycles.
The
product
selectivity
between
2,5-dihydropyrrole
pyrrole
can
be
tuned
by
altering
the
substituent
on
N
atom
1,6-diyne.
We
highlight
intricacy
efficiency
approach
in
constructing
molecular
frameworks
under
mild
conditions
with
high
functional
group
tolerance.
This
study
elucidates
mechanism
underlying
selectivity,
highlighting
its
potential
as
compelling
alternative
to
traditional
synthetic
techniques.
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 28, 2025
A
Mn(III)-mediated
radical
cascade
cyclization
of
N-propargyl
enamides
with
sodium
sulfinates
was
developed.
Mechanistic
studies
indicated
that
this
process
is
mainly
composed
the
chemoselective
addition
sulfonyl
to
C≡C
bond
and
regioselective
intramolecular
6-endo-trig
cyclization.
This
protocol
provided
a
powerful
method
for
divergent
synthesis
diverse
polysubstituted
meta-sulfonylpyridines
or
1,2-dihydropyridines
just
by
varying
solvent
temperature
featuring
good
functional
group
compatibility
simple
operation.
European Journal of Organic Chemistry,
Год журнала:
2023,
Номер
26(25)
Опубликована: Апрель 25, 2023
Abstract
Compounds
containing
sulfonyl‐derived
functional
groups
have
received
intensive
attention
owing
to
their
widespread
applications
in
life
science,
pharmaceuticals
and
materials
science.
To
access
this
type
of
compounds,
the
multi‐component
sulfonylation
reactions
relying
on
sulfur
dioxide
(SO
2
)
insertion
strategy
emerged
as
novel
attractive
approaches
past
decade.
The
utilization
SO
surrogates
for
multicomponent
(MCRs)
improved
reaction
flexibility
step
economy.
Moreover,
some
advances
been
achieved
challenging
but
practical
asymmetric
MCRs
construction
high
value‐added
chiral
sulfones.
This
review
aims
summarize
progress
made
involving
from
2019
2022,
point
out
potentials
challenges
field.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(15), С. 4275 - 4283
Опубликована: Янв. 1, 2024
A
copper-catalyzed
enantioselective
four-component
reaction
via
the
insertion
of
sulfur
dioxide
toward
synthesis
chiral
sulfones
bearing
an
all-carbon
quaternary
stereocenter
at
β
position
is
reported.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(20), С. 5784 - 5790
Опубликована: Янв. 1, 2024
The
radical
cascade
cyclization
of
vinyl-tethered
alkenes
has
become
a
promising
tool
for
rapidly
assembling
nonbenzene-fused
cyclic
skeletons
via
the
cracking
alkenyl
C–H
bonds,
but
this
approach
been
limited
to
generate
five-membered
rings.
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 14, 2025
A
novel
regioselective
manganese(III)-mediated
radical
cascade
cyclization
of
N-propargyl
enamides
with
various
H-phosphine
oxides,
H-phosphinates
and
H-phosphonates
was
developed.
Mechanistic
studies
show
that
the
reaction
is
mainly
composed
selective
addition
phosphonyl
to
C≡C
bond
intramolecular
6-endo-trig
vinyl
radical.
Utilizing
this
protocol,
we
successfully
synthesized
a
diverse
range
3-phosphorylpyridines
in
high
efficiency
good
functional
group
compatibility
simple
operation.
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 5, 2025
A
copper(II)-catalyzed
radical
cascade
reaction
of
N-propargyl
enamides
with
sulfonyl
hydrazides
was
developed,
which
provided
an
unprecedented
method
for
the
direct
synthesis
meta-sulfonylpyridines
in
high
efficiency
good
functional
group
compatibility
and
simple
operation.
Mechanistic
studies
indicated
that
this
tandem
process
might
be
composed
addition,
intramolecular
cyclization
oxidative
aromatization.
Chemical Communications,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
An
efficient
visible-light-induced
radical
cascade
cyclization
of
1,5-dienes
with
α-keto
acids
and
water
to
access
diverse
acylated
pyrrolidinones
was
developed.
Molecules,
Год журнала:
2023,
Номер
28(14), С. 5473 - 5473
Опубликована: Июль 17, 2023
A
mild,
visible-light-induced,
regioselective
cascade
sulfonylation-cyclization
of
1,5-dienes
with
sulfonyl
chlorides
through
the
intermolecular
radical
addition/cyclization
alkenes
C(sp2)-H
was
developed.
This
procedure
proceeds
well
and
affords
a
mild
efficient
route
to
range
monosulfonylated
pyrrolin-2-ones
at
room
temperatures.
Organic Chemistry Frontiers,
Год журнала:
2023,
Номер
10(13), С. 3239 - 3244
Опубликована: Янв. 1, 2023
A
copper-catalyzed
three-component
sulfonylation
reaction
is
presented.
This
protocol
provides
easy
and
straightforward
access
to
structurally
diverse
γ-keto
aryl
sulfones
with
good
yields,
mild
conditions,
low
catalyst
loading,
functional
group
tolerance.
