Energy Transfer Influence on Superfast Calcium Carbonate Synthesis: using Microwave Heating, Ultrasound Cavitation and Mechanical Stirring

Journal of Materials Research and Technology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

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Clinical perspective on topical vaccination strategies

Advanced Drug Delivery Reviews, Год журнала: 2024, Номер 208, С. 115292 - 115292

Опубликована: Март 24, 2024

Vaccination is one of the most successful measures in modern medicine to combat diseases, especially infectious and saves millions lives every year. Vaccine design development remains critical involves many aspects, including choice platform, antigen, adjuvant, route administration. Topical vaccination, defined herein as introduction a vaccine any three layers human skin, has attracted interest recent years an alternative vaccination approach conventional intramuscular administration because its potential be needle-free induce superior immune response against pathogens. In this review, we describe progress developing topical vaccines, highlight delivery technologies for discuss factors that might impact efficacy, provide overview current clinical landscape vaccines.

Язык: Английский

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Encapsulation of a small-molecule drug based on substituted 2-aminothiophenes in calcium carbonate carriers for therapy of melanoma

Biomaterials Science, Год журнала: 2024, Номер 12(13), С. 3431 - 3445

Опубликована: Янв. 1, 2024

Encapsulation of 2-aminothiophenes in calcium carbonate particles leads to improved antitumor activity against melanoma.

Язык: Английский

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Optical Methods for Non-Invasive Determination of Skin Penetration: Current Trends, Advances, Possibilities, Prospects, and Translation into In Vivo Human Studies

Pharmaceutics, Год журнала: 2023, Номер 15(9), С. 2272 - 2272

Опубликована: Сен. 3, 2023

Information on the penetration depth, pathways, metabolization, storage of vehicles, active pharmaceutical ingredients (APIs), and functional cosmetic (FCIs) topically applied formulations or contaminants (substances) in skin is great importance for understanding their interaction with targets, treatment efficacy, risk assessment—a challenging task dermatology, cosmetology, pharmacy. Non-invasive methods qualitative quantitative visualization substances vivo are favored limited to optical imaging spectroscopic such as fluorescence/reflectance confocal laser scanning microscopy (CLSM); two-photon tomography (2PT) combined autofluorescence (2PT-AF), fluorescence lifetime (2PT-FLIM), second-harmonic generation (SHG), coherent anti-Stokes Raman scattering (CARS), reflectance (2PT-RCM); three-photon (3PT); micro-spectroscopy (CRM); surface-enhanced (SERS) micro-spectroscopy; stimulated (SRS) microscopy; coherence (OCT). This review summarizes state art use CLSM, 2PT, 3PT, CRM, SERS, SRS, OCT study non-invasively (302 references). The advantages, limitations, possibilities, prospects reviewed comprehensively discussed. ex studies discussed potentially translatable into measurements. requirements properties determine by certain highlighted.

Язык: Английский

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Exploiting Benefits of Vaterite Metastability to Design Degradable Systems for Biomedical Applications

Pharmaceutics, Год журнала: 2023, Номер 15(11), С. 2574 - 2574

Опубликована: Ноя. 2, 2023

The widespread application of calcium carbonate is determined by its high availability in nature and simplicity synthesis laboratory conditions. Moreover, possesses highly attractive physicochemical properties that make it suitable for a wide range biomedical applications. This review provides conclusive analysis the results on using tunable vaterite metastability development biodegradable drug delivery systems therapeutic vehicles with controlled sustained release incorporated cargo. manuscript highlights nuances recrystallization to non-porous calcite, dissolution at acidic pH, biodegradation vivo conditions control over these processes. outlines main benefits instability liberation encapsulated molecules natural synthetic polymeric materials purposes.

Язык: Английский

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Current issues in optical monitoring of drug delivery via hair follicles

Advanced Drug Delivery Reviews, Год журнала: 2024, Номер unknown, С. 115477 - 115477

Опубликована: Ноя. 1, 2024

Язык: Английский

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Microfluidically Assisted Synthesis of Calcium Carbonate Submicron Particles with Improved Loading Properties

Micromachines, Год журнала: 2023, Номер 15(1), С. 16 - 16

Опубликована: Дек. 21, 2023

The development of advanced methods for the synthesis nano- and microparticles in field biomedicine is high interest due to a range reasons. current may have limitations terms efficiency, scalability, uniformity particles. Here, we investigate submicron calcium carbonate using microfluidic chip with T-shaped oil supply droplet-based facilitate control over formation design allowed precise manipulation reaction parameters, resulting improved porosity while maintaining an efficient rate. pore size distribution within particles was estimated via small-angle X-ray scattering. This study showed that reduced facilitated higher loading model peptide: 16 vs. 9 mass.% synthesized device bulk, correspondingly. biosafety developed concentration 0.08–0.8 mg per plate established by results cytotoxicity mouse fibroblasts. innovative approach microfluidically assisted provides promising avenue future research particle drug delivery systems.

Язык: Английский

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Biodegradable calcium carbonate carriers for the topical delivery of clobetasol propionate

Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(20), С. 4867 - 4881

Опубликована: Янв. 1, 2024

Inflammatory dermatoses represent a global problem with increasing prevalence and recurrence among the world population. Topical glucocorticoids (GCs) are most commonly used anti-inflammatory drugs in dermatology due to wide range of their therapeutic actions, which, however, have numerous local systemic side effects. Hence, there is growing need create new delivery systems for GCs, ensuring drug localization pathological site, thus effectiveness therapy lowering risk Here, we propose novel topical particulate formulation GC clobetasol propionate (CP), based on use porous calcium carbonate (CaCO3) carriers vaterite crystalline form. The designed contain substantially higher CP amount than conventional dosage forms clinics (4.5% w/w vs. 0.05% w/w) displayed good biocompatibility effective cellular uptake when studied fibroblasts vitro. Hair follicles an important reservoir accumulation skin house targets its action. In this study, demonstrated successful CP-loaded (CP-CaCO3) into hair rats vivo using optical coherent tomography (OCT). Importantly, OCT monitoring revealed gradual intrafollicular degradation within 168 h abundant follicle filling occurring first 48 h. Biodegradability makes proposed system especially promising searching formulations improved safety release profile. Our findings evidenced great potential CaCO3 improving dermal bioavailability poorly water-soluble GC.

Язык: Английский

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Microfluidic-assisted synthesis of hybrid calcium carbonate/silver microparticles

Кристаллография, Год журнала: 2024, Номер 69(4), С. 685 - 693

Опубликована: Сен. 25, 2024

Язык: Английский

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Investigation and Release Profile Optimization for Vaterite-Based Carriers Loaded with Betamethasone Dipropionate

BioNanoScience, Год журнала: 2024, Номер 15(1)

Опубликована: Дек. 5, 2024

Язык: Английский

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