Antibiotic residues in commercial freshwater fish from southeast China: distribution and human health risk assessment
Environmental Science and Pollution Research,
Год журнала:
2024,
Номер
31(16), С. 23780 - 23789
Опубликована: Март 2, 2024
Язык: Английский
Occurrence and risk assessment of coccidiostat residues in chicken meat: A regional study in southeast China
Food Bioscience,
Год журнала:
2024,
Номер
62, С. 105024 - 105024
Опубликована: Сен. 1, 2024
Язык: Английский
Untargeted Profiling of Shenfu Qiangxin Pills Based on High Resolution Mass Spectrometry and Absolute Quantitation of Multiple Components Using Parallel Reaction Monitoring
Yan Gao,
Xv Liang,
Nihui Zhang
и другие.
Опубликована: Янв. 1, 2024
Shenfu
Qiangxin
(SFQX)
pills
are
proprietary
traditional
Chinese
medicine
used
for
the
treatment
of
chronic
heart
failure
(CHF)
with
significant
clinical
effects.
However,
a
systematic
identification
and
quantification
complexed
components
is
lacking.
In
this
work,
reliable
comprehensive
method
rapid
chemical
was
developed
using
ultra
performance
liquid
chromatography
coupled
high
resolution
mass
spectrometry
(UPLC-Q
Exactive-Orbitrap-MS).
A
total
104
compounds
including
flavonoids,
saponins,
alkaloids,
anthraquinones,
coumarins,
phenolic
acids
others
were
identified
through
database
searching.
Identified
further
ascribed
to
herb
species
in
SFQX
pills,
such
as
Ginseng
Radis
Et
Rhizoma,
Aconiti
Lateralis
Radix
Praeparata
(processed),
Mori
Cortex,
Lepidii
Semen,
Rhei
Polyporus.
Among
32
representative
elaborated
cleavage
pathways
characteristic
fragments
MS2
spectrum
commercially
available
standards.
based
on
parallel
reaction
monitoring
(PRM)
technique
established,
absolute
28
then
carried
out.
The
results
study
can
provide
basis
methodological
reference
quality
control,
consistency
evaluation,
standardization
similar
medicines.
Язык: Английский
Untargeted Profiling of Shenfu Qiangxin Pills Based on High‐Resolution Mass Spectrometry and Absolute Quantitation of Multiple Components Using Parallel Reaction Monitoring
Yan Gao,
Xv Liang,
Nihui Zhang
и другие.
Journal of Separation Science,
Год журнала:
2024,
Номер
47(23)
Опубликована: Дек. 1, 2024
ABSTRACT
Shenfu
Qiangxin
(SFQX)
pills
are
proprietary
traditional
Chinese
medicine
used
for
the
treatment
of
chronic
heart
failure
with
significant
clinical
effects.
However,
systematic
identification
and
quantification
complexed
components
in
SFQX
have
not
been
reported
yet.
In
this
work,
a
reliable
comprehensive
method
rapid
chemical
was
developed
by
data
dependent
acquisition
using
ultra
performance
liquid
chromatography
coupled
high‐resolution
mass
spectrometry
(UHPLC‐Q
Exactive‐Orbitrap‐MS).
A
total
104
compounds
mainly
including
flavonoids,
saponins,
alkaloids,
anthraquinones,
coumarins,
phenolic
acids
were
identified
through
database
searching.
The
further
ascribed
to
herb
species
pills,
such
as
Ginseng
Radis
et
Rhizoma
,
Aconiti
Lateralis
Radix
Praeparata
(processed),
Mori
Cortex
Lepidii
Semen
Rhei
Polyporus
.
Thirty‐two
representative
elaborated
cleavage
pathways
characteristic
fragments
MS/MS
spectrum
commercially
available
standards.
based
on
parallel
reaction
monitoring
technique
established,
absolute
28
then
carried
out.
This
work
constitutes
basis
methodological
reference
quality
control,
consistency
evaluation,
standardization
similar
medicines.
Язык: Английский
Antibiotic residues in commercial freshwater fish from southeast China: distribution and human health risk assessment
Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Дек. 19, 2023
Abstract
We
investigated
14
antibiotic
residues
in
8
marketed
freshwater
fish
species
from
southeast
China
and
estimated
the
associated
health
risks
to
local
consumers.
The
were
determined
by
UPLC-MS/MS.
Our
findings
revealed
widespread
distribution
of
quinolones
(QNs),
tetracyclines
(TCs),
chloramphenicols
(CAPs)
fish.
Notably,
average
concentrations
enrofloxacin
ciprofloxacin
reached
levels
as
high
62.5
µg/kg
wet
weight
(ww)
11.7
ww,
respectively,
detection
frequencies
68.7%
for
31.6%
ciprofloxacin.
Additionally,
we
detected
chloramphenicol,
a
prohibited
antibiotic,
samples
with
frequency
0.76%.
Among
species,
mean
concentration
total
was
highest
bluntnose
black
bream
(263.3
µg/kg),
followed
English
perch
(52.4
crucian
carp
(46.3
(28.6
yellowcheek
(21.0
grass
(15.3
bighead
(3.78
mandarin
(3.69
µg/kg).
daily
intake
values
these
which
lower
than
acceptable
hazard
indexes
much
less
1.
It
indicates
there
is
very
low
direct
risk
Despite
that,
investigation
on
chronic
impact,
such
antibiotic-resistant
bacteria,
gut
microbiota
disruption
allergic
reactions
urgently
needed.
Язык: Английский