Soft Materials,
Год журнала:
2024,
Номер
22(3), С. 173 - 182
Опубликована: Июнь 16, 2024
Bilayer
hydrogels
composed
of
poly(N-isopropylacrylamide)
(PNIPAm)
and
poly(acrylic
acid-co-acrylamide)
(P(AAc-co-AAm))
are
commonly
utilized
as
anisotropic
with
temperature
pH
sensitivity.
Nonetheless,
PNIPAm
is
known
to
possess
poor
mechanical
properties,
a
slow
thermal
response,
brittleness,
which
greatly
restricts
its
application
for
In
order
overcome
these
limitations,
semi-interpenetrating
network
(semi-IPN)
structure
was
created
by
combining
sodium
alginate.
This
effectively
addressed
the
issue
PNIPAm's
increased
tensile
stress,
improved
strain.
Notably,
porogen
such
carbonate
incorporated
increase
porosity
thermo-sensitive
layer
hydrogel,
resulting
in
faster
response
rate.
The
bilayer
hydrogel
obtained
can
be
used
bidirectional
driver
both
Mechanical
manipulation
through
changes
or
shifts
cause
significant
deformation
making
it
promising
material
soft
actuator
applications.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(18)
Опубликована: Март 23, 2024
Intense
and
persistent
oxidative
stress,
excessive
inflammation,
impaired
angiogenesis
severely
hinder
diabetic
wound
healing.
Bioactive
hydrogel
dressings
with
immunoregulatory
proangiogenic
properties
have
great
promise
in
treating
wounds.
However,
the
therapeutic
effects
of
always
depend
on
drugs
side
effects,
expensive
cytokines,
cell
therapies.
Herein,
a
novel
dynamic
borate-bonds
crosslinked
hybrid
multifunctional
photothermal
are
developed
to
regulate
microenvironment
sites
accelerate
whole
process
its
healing
without
additional
medication.
The
is
composed
phenylboronic
acid-modified
chitosan
hyaluronic
acid
(HA)
by
tannic
(TA)
through
borate
bonds
Prussian
blue
nanoparticles
(PBNPs)
response
characteristics
embedded
polymer
networks.
results
indicate
hydrogels
show
inherent
broad-spectrum
antioxidative
activities
integrated
interaction
bonds,
TA,
PBNPs.
Meanwhile,
combined
regulation
macrophage
phenotype
HA,
inflammatory
wounds
transformed.
Moreover,
then
enhanced
mild
effect
PBNPs,
followed
promoted
epithelialization
collagen
deposition.
In
summary,
this
system
accelerates
all
stages
repair
immunomodulation,
proangiogenesis,
showing
potential
applications
management.
Extrusion-based
3D
printing
is
a
facile
technology
to
construct
complex
structures
of
hydrogels,
especially
for
tough
hydrogels
that
have
shown
demonstrated
potential
in
load-bearing
materials
and
tissue
engineering.
However,
3D-printed
often
possess
mechanical
properties
do
not
guarantee
their
usage
tissue-mimicking,
components,
motion
sensors.
This
study
proposes
novel
strategy
high-strength
anisotropic
Fe
Materials Today Bio,
Год журнала:
2024,
Номер
27, С. 101110 - 101110
Опубликована: Июнь 4, 2024
Cellular
alignment
plays
a
pivotal
role
in
several
human
tissues,
including
skeletal
muscle,
spinal
cord
and
tendon.
Various
techniques
have
been
developed
to
control
cellular
using
3D
biomaterials.
However,
the
majority
of
3D-aligned
scaffolds
require
invasive
surgery
for
implantation.
In
contrast,
injectable
hydrogels
provide
non-invasive
delivery
method,
gaining
considerable
attention
treatment
diverse
conditions,
osteochondral
lesions,
volumetric
muscle
loss,
traumatic
brain
injury.
We
engineered
biomimetic
hydrogel
with
magnetic
responsiveness
by
combining
gellan
gum,
hyaluronic
acid,
collagen,
nanoparticles
(MNPs).
Collagen
type
I
was
paired
MNPs
form
collagen
bundles
(MCollB),
allowing
orientation
these
within
matrix
through
application
remote
low-intensity
field.
This
resulted
creation
an
anisotropic
architecture.
The
mechanical
properties
were
comparable
those
soft
such
as
proof
aligned
concept
demonstrated.
vitro
findings
confirmed
absence
toxicity
pro-inflammatory
effects.
Notably,
increased
fibroblast
cell
proliferation
pro-regenerative
activation
macrophages
observed.
in-vivo
study
further
validated
biocompatibility
demonstrated
feasibility
injection
rapid
situ
gelation.
Consequently,
this
magnetically
controlled
exhibits
significant
promise
minimally
invasive,
gelling
effective
regenerating
various
tissues.
Materials Science and Engineering R Reports,
Год журнала:
2024,
Номер
160, С. 100824 - 100824
Опубликована: Июль 17, 2024
Triterpenoids
are
natural
bioactive
compounds
that
demonstrate
cytotoxic
and
chemopreventive
activities
by
inhibiting
various
intracellular
signals
transcription
factors.
Despite
their
efficacy,
triterpenoid
chemotherapeutics
face
significant
challenges
in
cancer
therapy
because
of
poor
aqueous
solubility,
which
restricts
the
utilization
potent
drug
variants.
Consequently,
there
is
a
pressing
need
to
develop
solubilized
form
encapsulated
within
mechanically
robust
biomaterials,
facilitate
injectable
minimally
invasive
delivery.
In
this
study,
we
focused
on
ginsenoside
compound
K
(CK),
pentacyclic
triterpenoid.
It
was
conjugated
hyaluronic
acid
(HA-CK)
employed
as
novel
guest
molecule
for
binding
β-cyclodextrin-grafted
(HA-βCD),
host
polymer.
This
interaction
resulted
creation
an
supramolecular
hydrogel
(HG-Gel)
through
straightforward
mixing
process
involving
host–guest
interactions
between
βCD
CK.
The
physical
properties
hydrogels
were
easily
manipulated
altering
molecular
weight
HA
grafting
degree
CK
HA.
Notably,
precursors
exhibited
excellent
cell
viability
normal
cells,
sparing
over
80
%
NIH
3T3
HaCaT
cells.
Intriguingly,
these
facilitated
effective
delivery
CD44-overexpressing
suppressing
proliferation.
Enhanced
trafficking
cells
heightened
caspase-dependent
apoptosis
B16F10
with
extent
death
contingent
expression
levels
CD44
effect
seems
be
mediated
induction
reactive
oxygen
species
(ROS)
mitochondrial
membrane
potential
loss.
melanoma
tumor-bearing
mouse
models,
HG-Gels
effectively
inhibited
tumor
growth.
Importantly,
no
side
effects
observed
tissues,
underscoring
safety
naturally
derived
biomaterials.
study
underscores
superiority
platform
utilizing
saponins
therapy,
suggesting
enhancing
efficacy
triterpenoids
treatment.
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(31), С. 7463 - 7479
Опубликована: Янв. 1, 2024
The
number
of
patients
with
non-healing
wounds
continuously
increases,
and
has
become
a
prominent
societal
issue
that
imposes
heavy
burden
on
both
the
entire
healthcare
system.
Although
traditional
dressings
play
an
important
role
in
wound
healing,
complexity
diversity
healing
process
pose
serious
challenges
this
field.
Magneto-responsive
biocomposites,
their
excellent
biocompatibility,
remote
spatiotemporal
controllability,
unique
convenience,
demonstrate
enticing
advantages
field
dressings.
However,
current
research
magneto-responsive
biocomposites
as
lacks
comprehensive
in-depth
reviews,
which
to
some
extent,
restricts
deeper
understanding
further
development
Based
this,
paper
reviews
latest
advances
magnetic
responsive
for
healing.
First,
we
review
skin
parameters
assessing
repair
progress.
Then,
systematically
discuss
preparation
strategies
characteristics
focusing
magneto-induced
orientation,
mechanical
stimulation,
magnetocaloric
effect.
Subsequently,
elaborates
multiple
mechanisms
promoting
including
regulating
cell
behavior,
enhancing
electrical
signal,
controlling
drug
release,
accelerating
tissue
reconstruction.
Finally,
propose
direction
future
biomaterials
clinical
application.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
13
Опубликована: Фев. 17, 2025
Osteoarthritis
is
one
of
the
most
common
degenerative
joint
diseases,
which
seriously
affects
life
middle-aged
and
elderly
people.
Traditional
treatments
such
as
surgical
treatment
systemic
medication,
often
do
not
achieve
expected
or
optimal
results,
leads
to
severe
trauma
a
variety
side
effects.
Therefore,
there
an
urgent
need
develop
novel
therapeutic
options
overcome
these
problems.
Hydrogels
are
widely
used
in
biomedical
tissue
repairing
platform
for
loading
drugs,
proteins
stem
cells.
In
recent
years,
smart-responsive
hydrogels
have
achieved
excellent
results
drug
delivery
systems
osteoarthritis.
This
review
focuses
on
advances
endogenous
stimuli
(including
enzymes,
pH,
reactive
oxygen
species
temperature,
etc.)
responsive
exogenous
light,
shear,
ultrasound
magnetism,
osteoarthritis
treatment.
Finally,
current
limitations
application
future
prospects
smart
summarized.
Abstract
Controlling
cellular
organization
in
hydrogels
is
of
great
interest
tissue
engineering
and
regenerative
medicine.
In
the
body,
cell
regulated
by
aligned
extracellular
matrices,
such
as
collagen
fibers.
However,
generating
patterned
matrix
fibers
hydrogels,
microfabricated
gels,
not
easily
accomplished.
Here,
filamented‐light
(FLight)–based
3D
microfabrication
used
to
fabricate
microgels
with
precise
internal
architecture
direct
organization.
It
demonstrated
that
fibrillated
rod‐shaped
encapsulating
C2C12
muscle
cells
promote
highly
myotube
formation,
offering
potential
mini‐injectable
tissues
for
minimally
invasive
loss
therapies.
Furthermore,
photoreceptor
encapsulated
generated
structures
mimicked
outer
retina.
Moreover,
these
can
be
injectable
scaffolds,
both
vitro
vivo,
where
they
facilitate
angiogenesis
when
conjugated
QK
peptide.
Overall,
this
technique
generate
thus
providing
a
potentially
significant
tool
tissue‐like
structures.
