Identification of novel tumor antigens and immune subtypes in breast cancer patients for mRNA vaccine development DOI Creative Commons

Haiyan Yu,

Jun‐Ping Liu, Lintai Li

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Март 15, 2024

Abstract Background:Breast cancer has overtaken lung as the world's most common malignancy. Despite development of some mRNA vaccines, no satisfactory vaccination for breast entered clinical application.Methods:In this study, we used multiple analyses expression datasets from public sources to find new possible tumor antigens and hunt potential treatment-sensitive patients.Results:We identified DST, ANO6, LAMA3, NEDD9 putative candidates. Furthermore, found five predictive genes identify specific patients inclined vaccination, namely TRBC2, CD3D, CD27, CD3E, TRBV28. Following that, discovered three immunological subtypes cancer, Cluster 1 3, which were recognized "cold tumors" with minimal immune activity more likely respond vaccination. We uncovered that 3 could be further separated into two subgroups, each distinct cell infiltration patterns, suggesting vaccine responses differ among these patients. The findings our study lay theoretical foundation provide opportunities personalized treatment.

Язык: Английский

siRNA-Encapsulated Biomimetic Liposomes Effectively Inhibit Tumor Cells’ Hexosamine Biosynthesis Pathway for Attenuating Hyaluronan Barriers to Pancreatic Cancer Chemotherapy DOI
Jing Wu, Yunlong Cheng,

Kang Qian

и другие.

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Фев. 20, 2025

Pancreatic ductal adenocarcinoma (PDAC) poses significant therapeutic challenges due to excessive hyaluronic acid (HA) accumulation, which impedes drug delivery. Here, we present a targeted approach reduce HA production by specifically silencing glutamine-fructose-6-phosphate aminotransferase 1 (GFAT1), key enzyme of the hexosamine biosynthesis pathway (HBP) in pancreatic cancer cells. An engineered liposomal system for siGFAT1 delivery, PMLip@siGFAT1, characterized macrophage membrane camouflage, LFC131 peptide-mediated targeting, and calcium phosphate (CaP) as core, was designed ensure prolonged circulation, enhanced inflamed vascular endothelial penetration, subsequent effective tumor cell uptake endosomal escape. Consequently, PMLip@siGFAT1 markedly downregulated level PDAC microenvironment, decompressing vasculature weakening stromal barrier, turn improved permeability chemotherapeutics. In combination with Doxil, demonstrated potent antitumor efficacy minimal systemic toxicity. Importantly, unlike PEGPH20 (hyaluronidase), reduced invasiveness, while preserving skeletal muscle integrity. These findings highlight that holds great potential revitalize downregulation strategies delivery efficacy.

Язык: Английский

Процитировано

3
Regulation of cancer-associated fibroblasts for enhanced cancer immunotherapy using advanced functional nanomedicines: an updated review DOI Creative Commons
Tingting Liao, Xiaoxiao Chen,

Fengkai Qiu

и другие.

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Март 4, 2025

The tumor microenvironment (TME) is a complex and dynamic ecosystem that plays critical role in cancer progression. It comprises various cell types, including immune cells, stromal cells. Among these, cancer-associated fibroblasts (CAFs) represent heterogeneous population with diverse origins, phenotypes, functions. Activated CAFs secrete multiple factors promote growth, migration, angiogenesis, contribute to chemoresistance. Additionally, extracellular matrix (ECM) components, such as collagen, which form physical barrier hinders the penetration of chemotherapeutic immunotherapeutic agents. This ECM also influences infiltration, impeding their ability effectively target As result, modulating activity has emerged promising strategy enhance efficacy immunotherapy. Nano-delivery systems, constructed from nanomaterials high targeting specificity biocompatibility, offer compelling approach deliver therapeutic agents or immunomodulatory directly CAFs. modulation can alter CAF function, reduce tumor-promoting effects, thereby improve outcomes review provides an in-depth exploration functions, interactions within TME, particularly context suppression. Furthermore, it discusses potential applications functional nanocarrifers enhancing effectiveness immunotherapy, highlighting significant progress nanotechnology this area.

Язык: Английский

Процитировано

3
Extensive Review of Nanomedicine Strategies Targeting the Tumor Microenvironment in PDAC DOI Creative Commons

Xing Liu,

Yidan Shao,

Yunjiang Li

и другие.

International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 3379 - 3406

Опубликована: Март 1, 2025

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers in world, mainly because its powerful pro-connective tissue proliferation matrix and immunosuppressive tumor microenvironment (TME), which promote progression metastasis. In addition, extracellular leads to vascular collapse, increased interstitial fluid pressure, obstruction lymphatic return, thereby hindering effective drug delivery, deep penetration, immune cell infiltration. Therefore, reshaping TME enhance perfusion, increase reverse suppression has become a key therapeutic strategy. Traditional therapies for PDAC, including surgery, radiation, chemotherapy, face significant limitations. Surgery challenging due location growth, while chemotherapy radiation are hindered by dense TME. recent years, advancement nanotechnology provided new opportunities improve efficacy. Nanoscale delivery systems (NDDSs) provide several advantages, improved stability vivo, enhanced reduced systemic toxicity. However, clinical translation PDAC therapy faces challenges. These include need precise targeting control over release, potential responses nanocarriers, scalability cost-effectiveness production. This article provides an overview latest nanobased methods achieving better outcomes overcoming resistance. We pay special attention TME-targeted context discuss advantages limitations current strategies, emphasize promising developments. By emphasizing enormous NDDSs improving treatment patients with critically discussing traditional challenges faced breakthroughs, our review paves way future research this rapidly developing field.

Язык: Английский

Процитировано

1
CAFs and T cells interplay: The emergence of a new arena in cancer combat DOI Creative Commons

Minjie Chen,

Fei Chen,

Zhaofeng Gao

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 177, С. 117045 - 117045

Опубликована: Июль 1, 2024

The interaction between the immune system and tumor matrix has a huge impact on progression treatment of cancer. This paper summarizes discusses crosstalk T cells cancer-associated fibroblasts (CAFs). CAFs can also produce inhibitors that counteract function promote escape, while engage in complex two-way interactions with through direct cell contact, exchange soluble factors such as cytokines, remodeling extracellular matrix. Precise targeted intervention effectively reverse tumor-promoting CAFs, improve anti-tumor response, provide new perspective for cancer treatment. Therefore, it is important to deeply understand mechanism CAFs. review aims outline underlying mechanisms these discuss potential therapeutic strategies may become fundamental tools cancer, especially hard-to-cure cancers.

Язык: Английский

Процитировано

6
Nanoparticle-based drug delivery systems: opportunities and challenges in the treatment of esophageal squamous cell carcinoma (ESCC) DOI Creative Commons

Linjia Peng,

Zixuan Gao,

Yan‐Feng Liang

и другие.

Nanoscale, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy characterized by limited treatment options and poor prognosis. Nanoparticle-based drug delivery systems have emerged as a promising strategy to enhance cancer therapy efficacy improving targeting, reducing toxicity, enabling multifunctional applications. This review highlights some key types of nanoparticles, including liposomes, polymeric metallic dendrimers, quantum dots, which could effectively improve the various drugs used in chemotherapy, radiotherapy, immunotherapy, offering more precise effective options. With ability stability overcome biological barriers, nanoparticle-based represent transformative for ESCC treatment. Despite challenges, such biocompatibility scalability, future holds great promise, particularly development personalized nanomedicine novel therapeutic approaches targeting tumor microenvironment. ongoing advancements, hold immense potential revolutionize patient outcomes.

Язык: Английский

Процитировано

0
A Comprehensive Review on Revolutionizing Pancreatic Cancer Treatment: Liposomal Innovations DOI

Rohit Sharma,

Km Komal,

Sourabh Kumar

и другие.

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 107032 - 107032

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0
Application of Liposome-Based Drug Delivery Systems in Tumor Treatment DOI

Wenbing Sun,

Wenfeng He

Journal of Cluster Science, Год журнала: 2025, Номер 36(4)

Опубликована: Июнь 2, 2025

Язык: Английский

Процитировано

0
Platinum-based chemotherapy: trends in organic nanodelivery systems DOI
João A. V. Santos,

Daniela Silva,

M. Paula M. Marques

и другие.

Nanoscale, Год журнала: 2024, Номер 16(31), С. 14640 - 14686

Опубликована: Янв. 1, 2024

This review explores organic nanodelivery systems in the development of platinum-based anticancer treatments, highlighting benefits, challenges, and potential for groundbreaking therapies.

Язык: Английский

Процитировано

3
Intelligent micelles for on-demand drug delivery targeting extracellular matrix of pancreatic cancer DOI
Chufeng Li, Qinjun Chen, Chen Jiang

и другие.

Journal of Controlled Release, Год журнала: 2024, Номер 373, С. 879 - 889

Опубликована: Авг. 5, 2024

Язык: Английский

Процитировано

2
Identification of novel tumor antigens and immune subtypes in breast cancer patients for mRNA vaccine development DOI Creative Commons

Haiyan Yu,

Jun‐Ping Liu, Lintai Li

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Март 15, 2024

Abstract Background:Breast cancer has overtaken lung as the world's most common malignancy. Despite development of some mRNA vaccines, no satisfactory vaccination for breast entered clinical application.Methods:In this study, we used multiple analyses expression datasets from public sources to find new possible tumor antigens and hunt potential treatment-sensitive patients.Results:We identified DST, ANO6, LAMA3, NEDD9 putative candidates. Furthermore, found five predictive genes identify specific patients inclined vaccination, namely TRBC2, CD3D, CD27, CD3E, TRBV28. Following that, discovered three immunological subtypes cancer, Cluster 1 3, which were recognized "cold tumors" with minimal immune activity more likely respond vaccination. We uncovered that 3 could be further separated into two subgroups, each distinct cell infiltration patterns, suggesting vaccine responses differ among these patients. The findings our study lay theoretical foundation provide opportunities personalized treatment.

Язык: Английский

Процитировано

1