Recent Advancements in Polymeric N-Nitrosamine-Based Nitric Oxide (NO) Donors and their Therapeutic Applications

Biomacromolecules, Год журнала: 2024, Номер 25(9), С. 5592 - 5608

Опубликована: Авг. 8, 2024

Nitric oxide (NO), a gasotransmitter, is known for its wide range of effects in vasodilation, cardiac relaxation, and angiogenesis. This diatomic free radical also plays pivotal role reducing the risk platelet aggregation thrombosis. Furthermore, NO demonstrates promising potential cancer therapy as well antibacterial antibiofilm activities at higher concentrations. To leverage their biomedical activities, numerous donors have been developed. Among these,

Язык: Английский

Application of Drug Delivery System Based on Nanozyme Cascade Technology in Chronic Wound

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(32)

Опубликована: Окт. 14, 2024

Abstract Chronic wounds are characterized by long‐term inflammation, including diabetic ulcers, traumatic etc., which provide an optimal environment for bacterial proliferation. At present, antibiotics the main clinical treatment method chronic wound infections. However, overuse of may accelerate emergence drug‐resistant bacteria, poses a significant threat to human health. Therefore, there is urgent need develop new therapeutic strategies Nanozyme‐based antimicrobial therapy (NABT) emerging strategy with broad‐spectrum activity and low drug resistance compared traditional antibiotics. NABT has shown great potential as catalyzing generation reactive oxygen species (ROS) its enzyme‐like catalytic properties, producing powerful bactericidal effect without developing resistance. cascade technology offers approach infection control, effectively improving efficacy activating cascades against cell membranes intracellular DNA while minimizing side effects. it worth noting that this still in early stages research. This article comprehensively reviews classification, current methods infection, different types nanozymes, application nanozyme reaction therapy, future challenges prospects.

Язык: Английский

Amphiphilic Janus Nanoparticles for Effective Treatment of Bacterial Pneumonia by Attenuating Inflammation and Targeted Bactericidal Capability

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 12039 - 12051

Опубликована: Ноя. 1, 2024

-induced pneumonia is marked by considerable infiltration of inflammatory cells and biofilm formation, which causes acute transient lung inflammation infection. Nevertheless, the discovery alternative preventative therapeutic methods essential due to high mortality rates in clinical settings resistance

Язык: Английский