Journal of Tissue Engineering,
Год журнала:
2024,
Номер
15
Опубликована: Янв. 1, 2024
Tissue
engineering
and
in
vitro
modeling
of
the
airways
lungs
respiratory
system
are
substantial
research
clinical
importance.
In
airway
lung
models
aim
to
improve
treatment
options
for
repair
advance
pathophysiological
research.
The
construction
biomimetic
native
with
tissue-specific
biological,
mechanical,
configurable
features
remains
challenging.
Bioprinting,
an
emerging
3D
printing
technology,
is
promising
development
airway,
lung,
disease
models,
allowing
incorporation
cells
biologically
active
molecules
into
printed
constructs
a
precise
reproducible
manner
recreate
airways,
architecture,
microenvironment.
Herein,
we
present
review
bioprinting
applications
tissue
modeling.
key
characteristics
interstitium,
alveoli
described.
bioinks
recently
used
summarized.
Furthermore,
propose
bioink
categorization
based
on
structural
airways.
Finally,
challenges
opportunities
biofabrication
discussed.
Journal of Functional Biomaterials,
Год журнала:
2025,
Номер
16(1), С. 28 - 28
Опубликована: Янв. 16, 2025
The
application
of
three-dimensional
(3D)
printing/bioprinting
technologies
and
cell
therapies
has
garnered
significant
attention
due
to
their
potential
in
the
field
regenerative
medicine.
This
paper
aims
provide
a
comprehensive
overview
3D
technology
therapies,
highlighting
results
diverse
medical
applications,
while
also
discussing
capabilities
limitations
combined
use.
synergistic
combination
printing
cellular
been
recognised
as
promising
innovative
approach,
it
is
expected
that
these
will
progressively
assume
crucial
role
treatment
various
diseases
conditions
foreseeable
future.
review
concludes
with
forward-looking
perspective
on
future
impact
technologies,
revolutionize
medicine
through
enhanced
tissue
repair
organ
replacement
strategies.
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 5, 2025
Engineered
living
systems
(ELSs)
represent
purpose-driven
assemblies
of
components,
encompassing
cells,
biomaterials,
and
active
agents,
intricately
designed
to
fulfill
diverse
biomedical
applications.
Gelatin
its
derivatives
have
been
used
extensively
in
ELSs
owing
their
mature
translational
pathways,
favorable
biological
properties,
adjustable
physicochemical
characteristics.
This
review
explores
the
intersection
gelatin
with
fabrication
techniques,
offering
a
comprehensive
examination
synergistic
potential
creating
for
various
applications
biomedicine.
It
offers
deep
dive
into
gelatin,
including
structures
production,
sources,
processing,
properties.
Additionally,
techniques
employing
derivatives,
generic
microfluidics,
3D
printing
methods.
Furthermore,
it
discusses
based
on
regenerative
engineering
as
well
cell
therapies,
bioadhesives,
biorobots,
biosensors.
Future
directions
challenges
are
also
examined,
highlighting
emerging
trends
areas
improvements
innovations.
In
summary,
this
underscores
significance
gelatin-based
advancing
lays
groundwork
guiding
future
research
developments
within
field.
Virtual and Physical Prototyping,
Год журнала:
2024,
Номер
19(1)
Опубликована: Июль 22, 2024
Achieving
efficient
scaffolds
for
bone
tissue
engineering
(TE)
requires
smartly
defined
parameters
reaching
a
balance
between
physical–chemical
properties,
biocompatibility
and
complex
architectures.
Three-dimensional
(3D)
printing
offers
precise
geometry
control
of
the
desired
scaffold
at
micro-scale.
However,
performance
3D
is
highly
dependent
on
formulation,
challenge
being
to
achieve
suitable
ink
establish
most
parameters.
Gelatin
methacryloyl
(GelMA)
emerges
as
promising
due
superior
biological
photocrosslinking
ability
printability.
The
present
review
focuses
evolution
GelMA-based
inks
bioinks
from
simplest
advanced
multicomponent
formulations
capable
regeneration.
Additionally,
comparative
analysis
different
photoinitiators
covered,
indicating
each
one's
advantages
disadvantages.
Furthermore,
main
bioprinting
methods
that
are
used
in
GelMA
outlined
with
required
their
influence
final
product
performance.
Bioprinting
is
a
highly
promising
application
area
of
additive
manufacturing
technology
that
has
been
widely
used
in
various
fields,
including
tissue
engineering,
drug
screening,
organ
regeneration,
and
biosensing.
Its
primary
goal
to
produce
biomedical
products
such
as
artificial
implant
scaffolds,
tissues
organs,
medical
assistive
devices
through
software-layered
discrete
numerical
control
molding.
Despite
its
immense
potential,
bioprinting
still
faces
several
challenges.
It
requires
concerted
efforts
from
researchers,
engineers,
regulatory
bodies,
industry
stakeholders
are
principal
overcome
these
challenges
unlock
the
full
potential
bioprinting.
This
review
systematically
discusses
principles,
applications,
future
perspectives
while
also
providing
topical
overview
research
progress
over
past
two
decades.
The
most
recent
advancements
comprehensively
reviewed
here.
First,
printing
techniques
methods
summarized
along
with
related
bioinks
supporting
structures.
Second,
interesting
representative
cases
regarding
applications
biosensing
introduced
detail.
Finally,
remaining
suggestions
for
directions
proposed
discussed.
one
areas
fields.
aims
devices.
perspectives,
which
provides
description
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Сен. 26, 2024
Introduction
Tissue
engineering
has
advanced
significantly
in
recent
years,
owing
primarily
to
additive
manufacturing
technology
and
the
combination
of
biomaterials
cells
known
as
3D
cell
printing
or
Bioprinting.
Nonetheless,
various
obstacles
remain
developing
adequate
printed
structures
for
biomedical
applications,
including
bioinks
optimization
meet
biocompatibility
printability
standards.
Hydrogels
are
among
most
intriguing
because
they
mimic
natural
extracellular
matrix
found
connective
tissues
can
create
a
highly
hydrated
environment
that
promotes
attachment
proliferation;
however,
their
mechanical
properties
weak
difficult
control,
making
it
print
proper
structure.
Methods
In
this
research,
hydrogels
based
on
Alginate
Gelatin
tested
evaluate
metabolic
activity,
going
beyond
qualitative
evaluation
viability.
The
easy-to-make
hydrogel
been
chosen
due
osmotic
requirements
metabolism,
possibility
combine
temperature
chemical
crosslinking.
Different
compositions
(%w/v)
(8%
gel-7%
alg,
4%
gel-4%
gel-2%
alg),
order
obtain
structure
up
10.3
±
1.4
mm.
Results
goal
paper
is
validate
obtained
cell-laden
terms
activity
7
days,
further
highlighting
difference
between
not
hydrogels.
To
end,
MS5
viability
determined
by
implementing
live/dead
staining
with
analysis
cellular
through
ATP
assay,
enhancing
actual
over
number.
Discussion
results
two
tests
always
comparable,
indicating
interchangeable
but
provide
complementary
pieces
information.
This
article
presents
MXenes'
potential
in
3D
bioprinting,
discussing
their
benefits
for
bio-printed
scaffolds,
bioprinting
techniques,
bio-ink
criteria,
applications
of
MXene-incorporated
constructs,
current
challenges,
and
future
directions.
