Organic & Biomolecular Chemistry,
Год журнала:
2023,
Номер
21(32), С. 6493 - 6497
Опубликована: Янв. 1, 2023
In
this
work,
we
wish
to
present
a
nickel-catalyzed
divergent
ring-contraction
and
ring-opening/isomerization
reaction
of
tert-cyclobutanols.
The
key
control
these
two
different
pathways
is
choose
appropriate
boronic
acid,
where
the
use
phenylboronic
acid
pyrimidin-5-ylboronic
enables
ring-opening
reaction/isomerization,
respectively.
Both
cyclopropyl
aryl
methanones
1-aryl
butan-1-ones
could
be
selectively
obtained.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(8)
Опубликована: Янв. 8, 2024
A
mild
photoredox
catalyzed
construction
of
sulfides,
disulfides,
selenides,
sulfoxides
and
sulfones
from
unstrained
ketone
precursors
is
introduced.
Combination
this
deacylative
process
with
S
Organic Chemistry Frontiers,
Год журнала:
2023,
Номер
10(20), С. 5190 - 5197
Опубликована: Янв. 1, 2023
An
efficient
and
rapid
iron-catalyzed
oxosulfonylation
of
alkynes
with
small-ring
compounds
Na
2
S
O
5
for
the
synthesis
β
-keto
sulfones
has
been
developed.
Palladium-catalyzed
asymmetric
transformations
involving
cyanide
anions
remain
a
challenge
due
to
the
strong
affinity
between
and
palladium,
which
induces
alterations
in
coordination
sphere
of
palladium
center.
Herein,
palladium-catalyzed
enantioselective
cyanation
is
achieved
via
ring-opening/cross-coupling
process
aryl
halide-tethered
cyclobutanones
Zn(CN)2.
This
reaction
demonstrated
exhibit
broad
substrate
scope
robust
enantioselectivity.
The
synthetic
utility
highlighted
by
converting
product
into
amide,
carboxylic
acid,
ester
without
racemization.
Angewandte Chemie,
Год журнала:
2024,
Номер
136(8)
Опубликована: Янв. 5, 2024
Abstract
A
mild
photoredox
catalyzed
construction
of
sulfides,
disulfides,
selenides,
sulfoxides
and
sulfones
from
unstrained
ketone
precursors
is
introduced.
Combination
this
deacylative
process
with
S
N
2
or
coupling
reactions
provides
novel
convenient
modular
strategies
toward
unsymmetrical
symmetric
disulfides.
Reactivity
studies
favor
a
bromine
radical
that
initiates
HAT
(Hydrogen
Atom
Transfer)
the
aminal
intermediate
resulting
in
expulsion
C‐centered
intercepted
to
make
C−S
C−Se
bonds.
Gram
scale
reactions,
broad
substrate
scope
tolerance
towards
various
functional
groups
render
method
appealing
for
future
applications
synthesis
organosulfur
selenium
complexes.
Synlett,
Год журнала:
2023,
Номер
34(20), С. 2486 - 2490
Опубликована: Июль 6, 2023
Abstract
The
transformation
of
cyclobutanones
into
acyclic
carbonyl
compounds
through
a
Pd-catalyzed
C–C
bond
cleavage
is
reported.
use
an
N-heterocyclic
carbene
ligand
efficiently
promoted
the
ring
opening
and
functionalization
various
cyclobutanones,
not
only
with
alcohols,
but
also
N-centered
nucleophiles,
such
as
aniline
or
amide
derivatives.
Cyclobutanones
were
found
to
react
arylboronic
esters,
resulting
in
production
aryl
ketones.
Organic Letters,
Год журнала:
2024,
Номер
26(39), С. 8244 - 8248
Опубликована: Сен. 23, 2024
A
palladium-catalyzed
asymmetric
tandem
carbonylation-Heck
reaction
of
cyclopentenes
with
carbon
monoxide
(CO)
has
been
disclosed.
This
desymmetrization
procedure
afforded
a
series
bicyclo[3.2.1]octenes
one
chiral
quaternary
and
tertiary
center
in
good
yields
enantioselectivities.
proceeds
via
an
acyl-palladium
intermediate,
followed
by
migratory
insertion
the
alkenes.
