The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(22), С. 16809 - 16827
Опубликована: Ноя. 1, 2024
A
photocatalytic
three-component
cascade
reaction
of
readily
available
enaminones,
hydrazines,
and
CBr4
for
the
synthesis
bromo-substituted
pyrazoles
in
one
pot
has
been
demonstrated.
This
strategy
involves
intermolecular
C-N/C-Br
bond
formation
represents
an
efficient
approach
to
construction
4-bromo-substituted
with
high
regioselectivity,
broad
substrate
scope,
good
functional
group
tolerance,
convenient
operation,
mild
conditions.
Mechanistic
investigations
show
that
this
proceeds
via
cyclization
enaminones
followed
by
a
regioselective
bromination
using
as
"Br"
source.
Organic & Biomolecular Chemistry,
Год журнала:
2023,
Номер
21(37), С. 7611 - 7615
Опубликована: Янв. 1, 2023
DBU-mediated
[3
+
2]
cycloaddition
reaction
for
the
synthesis
of
pyrazoles.
It
is
noteworthy
that
this
constructed
two
new
C–N
bonds
and
a
C–C
bond
at
same
time,
providing
door
construction
functionalization
pyrazole
scaffolds.
The Chemical Record,
Год журнала:
2024,
Номер
24(7)
Опубликована: Июль 1, 2024
Recently,
transition
metal-catalyzed
ortho-C-H
bond
activation/annulations
involving
two
internal
alkyne
molecules
have
been
extensively
used
to
synthesize
highly
substituted
polycyclic
aromatic
scaffolds.
Such
reactions
emerged
as
a
powerful
atom
and
step-economical
strategy
for
the
assembly
of
multifunctional
bioactive
molecules.
In
this
context,
we
focused
on
recent
achievements
dual
C-H
activation/annulations,
well
functionalization
diaryl/alkyl
alkynes.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(22), С. 16809 - 16827
Опубликована: Ноя. 1, 2024
A
photocatalytic
three-component
cascade
reaction
of
readily
available
enaminones,
hydrazines,
and
CBr4
for
the
synthesis
bromo-substituted
pyrazoles
in
one
pot
has
been
demonstrated.
This
strategy
involves
intermolecular
C-N/C-Br
bond
formation
represents
an
efficient
approach
to
construction
4-bromo-substituted
with
high
regioselectivity,
broad
substrate
scope,
good
functional
group
tolerance,
convenient
operation,
mild
conditions.
Mechanistic
investigations
show
that
this
proceeds
via
cyclization
enaminones
followed
by
a
regioselective
bromination
using
as
"Br"
source.
