Recent Progress in Synthetic Applications of Hypervalent Iodine(III) Reagents
Chemical Reviews,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 13, 2024
Hypervalent
iodine(III)
compounds
have
found
wide
application
in
modern
organic
chemistry
as
environmentally
friendly
reagents
and
catalysts.
iodine
are
commonly
used
synthetically
important
halogenations,
oxidations,
aminations,
heterocyclizations,
various
oxidative
functionalizations
of
substrates.
Iodonium
salts
arylating
reagents,
while
iodonium
ylides
imides
excellent
carbene
nitrene
precursors.
Various
derivatives
benziodoxoles,
such
azidobenziodoxoles,
trifluoromethylbenziodoxoles,
alkynylbenziodoxoles,
alkenylbenziodoxoles
group
transfer
the
presence
transition
metal
catalysts,
under
metal-free
conditions,
or
using
photocatalysts
photoirradiation
conditions.
Development
hypervalent
catalytic
systems
discovery
highly
enantioselective
reactions
chiral
represent
a
particularly
recent
achievement
field
chemistry.
Chemical
transformations
promoted
by
many
cases
unique
cannot
be
performed
any
other
common,
non-iodine-based
reagent.
This
review
covers
literature
published
mainly
last
7-8
years,
between
2016
2024.
Язык: Английский
Enantioselective copper-catalyzed azidation/click cascade reaction for access to chiral 1,2,3-triazoles
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Июнь 10, 2024
Chiral
1,2,3-triazoles
are
highly
attractive
motifs
in
various
fields.
However,
achieving
catalytic
asymmetric
click
reactions
of
azides
and
alkynes
for
chiral
triazole
synthesis
remains
a
significant
challenge,
mainly
due
to
the
limited
systems
substrate
scope.
Herein,
we
report
an
enantioselective
azidation/click
cascade
reaction
N-propargyl-β-ketoamides
with
readily
available
potent
azido
transfer
reagent
via
copper
catalysis,
which
affords
variety
up
99%
yield
95%
ee
under
mild
conditions.
Notably,
1,5-disubstituted
triazoles
that
have
not
been
accessed
by
previous
also
prepared
good
functional
group
tolerance.
Язык: Английский
Dearomative Amination Cyclization of Tryptamines and Tryptophols via Enantioselective 1,6‐Addition of p‐Quinone Diimides (p‐QDIs)
Asian Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 21, 2025
Abstract
A
method
utilizing
p
‐quinone
diimides
(
‐QDIs)
as
electrophilic
nitrogen
source
to
facilitate
a
highly
enantioselective
dearomative
cyclization
of
tryptamine
and
tryptophol
derivatives
has
been
developed.
This
approach
which
proceeds
via
1,6‐addition
‐QDIs
enables
the
rapid
efficient
synthesis
chiral
3‐amino‐pyrroloindoline
3‐amino‐furoindolines
with
excellent
stereochemical
control
(up
99%).
Development
an
alternate
one‐pot
method,
coupled
some
synthetic
transformations
further
elevates
practical
utility
this
strategy.
Язык: Английский
Recent Advances in Catalytic Enantioselective Synthesis of α-Chiral Tertiary Azides★
Acta Chimica Sinica,
Год журнала:
2023,
Номер
81(11), С. 1590 - 1590
Опубликована: Янв. 1, 2023
a
华东师范大学化学与分子工程学院
石油化工分子转化与反应工程全国重点实验室
上海分子治疗与新药创制工程
技术研究中心
上海市绿色化学与化工过程绿色化重点实验室
上海
200062)
(
b
中国科学院上海有机化学研究所
金属有机化学国家重点实验室
200032
Synthesis of indolyl pyrroloindolines via a cascade arylation/cyclization of indole acetamides with 3-substituted indoles
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(18), С. 5167 - 5171
Опубликована: Янв. 1, 2024
A
novel
TEA-mediated
cascade
arylation/cyclization
reaction
between
indole
acetamides
and
3-substituted
indoles
for
the
synthesis
of
various
indolyl
pyrroloindolines
has
been
developed.
Язык: Английский
Practical and regioselective halonitrooxylation of olefins to access β-halonitrates
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Авг. 20, 2024
Organic
nitrates,
as
effective
donors
of
the
signaling
molecule
nitric
oxide,
are
widely
applied
in
pharmaceutical
industry.
However,
practical
and
efficient
methods
for
accessing
organic
nitrates
still
scarce,
achieving
high
regiocontrol
unactivated
alkene
difunctionalization
remains
challenging.
Here
we
present
a
simple
method
highly
regioselective
halonitrooxylation
alkenes.
The
approach
utilizes
TMSX
(X:
Cl,
Br,
or
I)
oxybis(aryl-λ
Язык: Английский