Coordinating activation strategy enables 1,2-alkylamidation of alkynes DOI Creative Commons

Jing Ren,

XU Jun-hua,

Xiangxiang Kong

и другие.

Chemical Science, Год журнала: 2023, Номер 14(41), С. 11466 - 11473

Опубликована: Янв. 1, 2023

The radical 1,2-difunctionalization reaction of alkynes has been evolved into a versatile approach for expeditiously increasing the complexity common feedstock alkyne. However, intermolecular 1,2-carboamidation with general alkyl groups is an unsolved problem. Herein, we show that coordinating activation strategy could act as efficient tool enabling 1,2-alkylamidation alkynes. With employment diacyl peroxides both alkylating reagents and internal oxidants, large library β-alkylated enamides constructed in three-component manner from readily accessible amides This protocol exhibits broad substrate scope good functional group compatibility amenable late-stage functionalization natural molecules biologically compounds.

Язык: Английский

Cobalt-Catalyzed Three-Component Assembling of Aromatic Oximes with Substituted Dienes and Formaldehyde DOI

Priyambada Prusty,

Masilamani Jeganmohan

Chemical Communications, Год журнала: 2024, Номер 60(76), С. 10540 - 10543

Опубликована: Янв. 1, 2024

A cobalt-catalyzed three-component assembly of substituted aryl oximes with dienes and formaldehyde

Язык: Английский

Процитировано

4
Co(III)-Catalyzed Three-Component Assembling of 2-Pyridones with Dienes and Formaldehyde via C–H Bond Activation DOI

Priyambada Prusty,

Masilamani Jeganmohan

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Март 24, 2025

Here, we have demonstrated a Co(III)-catalyzed C–H functionalization of substituted pyridones with dienes and para-formaldehyde via three-component sequential reaction. A library homoallylic alcohols is synthesized high regio- chemoselectivity. The reaction scope widely compatible various N-pyridyl-2-pyridones, butadiene, dienes. Interestingly, N-pyridyl-4-pyridone also participated in the product was further converted into dihydrofuran-derived N-pyridyl-2-pyridone derivatives. convincing mechanism mechanistic investigations are described to justify current methodology.

Язык: Английский

Процитировано

0
Cu(I)-Catalyzed Highly Regioselective C–H Amidation of Quinoline N-Oxides with Dioxazolones DOI

Zhiqiang Ren,

Tianhui Feng,

Tianli Gao

и другие.

Organic Letters, Год журнала: 2024, Номер unknown

Опубликована: Сен. 30, 2024

A Cu(I)-catalyzed highly regioselective synthesis of 2-acetamidequinoline

Язык: Английский

Процитировано

1
Coordinating activation strategy enables 1,2-alkylamidation of alkynes DOI Creative Commons

Jing Ren,

XU Jun-hua,

Xiangxiang Kong

и другие.

Chemical Science, Год журнала: 2023, Номер 14(41), С. 11466 - 11473

Опубликована: Янв. 1, 2023

The radical 1,2-difunctionalization reaction of alkynes has been evolved into a versatile approach for expeditiously increasing the complexity common feedstock alkyne. However, intermolecular 1,2-carboamidation with general alkyl groups is an unsolved problem. Herein, we show that coordinating activation strategy could act as efficient tool enabling 1,2-alkylamidation alkynes. With employment diacyl peroxides both alkylating reagents and internal oxidants, large library β-alkylated enamides constructed in three-component manner from readily accessible amides This protocol exhibits broad substrate scope good functional group compatibility amenable late-stage functionalization natural molecules biologically compounds.

Язык: Английский

Процитировано

3