Separation and Purification Technology, Год журнала: 2024, Номер 358, С. 130399 - 130399
Опубликована: Ноя. 5, 2024
Язык: Английский
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Янв. 3, 2024
Abstract Successful oral insulin administration can considerably enhance the quality of life (QOL) diabetes patients who must frequently take injections. Oral administration, on other hand, is seriously hampered by gastrointestinal enzymes, wide pH range, mucus and mucosal layers, which limit bioavailability to ≤ 2%. Therefore, a large number technological solutions have been proposed increase insulin, in polymeric nanoparticles (PNPs) are highly promising for delivery. The recently published research articles chosen this review based applications PNPs with strong future potential delivery, do not cover all related work. In review, we will summarize controlled release mechanisms latest delivery nanocarrier, challenges prospect. This serve as guide investigators wish engineer study systems. Graphical
Язык: Английский
Процитировано
60
ACS Catalysis, Год журнала: 2024, Номер 14(4), С. 2631 - 2641
Опубликована: Фев. 6, 2024
The direct application of low-energy red light for photochemical transformations is synthetically appealing but practically challenging. Covalent organic frameworks (COFs) exhibit significant potential within this domain, owing to their broad spectrum absorption and prevalence in reactions, despite the fact that these photocatalysts are now mainly focused on using ultraviolet (UV) blue light. In study, an imidazole-linked porphyrin-based COF, PyPor-COF, which exhibits a wide band ranging from 200 700 nm, especially strong 630 expected be applied photocatalytic reactions. PyPor-COF possesses capacity selectively generate singlet oxygen (1O2) with high efficiency, renders it efficient photosensitizer reactions olefin cleavages thioanisole photooxidation under present study demonstrates intriguing prospect photoactive COFs as type II utilization photocatalyses.
Язык: Английский
Процитировано
35
Aggregate, Год журнала: 2024, Номер 5(2)
Опубликована: Янв. 4, 2024
Abstract The development of efficient drug delivery systems is essential for improving the efficacy and safety cancer drugs, particularly aggressive difficult‐to‐treat cancers. Covalent organic frameworks (COFs) are emerging as innovative porous nanomaterials in (DDS), due to their unique properties, including metal‐free skeleton, predetermined structures pore geometries, high porosity, large surface area, facile modification potential, good biocompatibility. These characteristics make COFs excellent candidates by enhancing loading capacity enabling precise encapsulation. This review emphasizes importance donor‐acceptor‐based COFs, which provide channels charge transportation, we also explore how π‐conjugated skeleton enhances its long‐acting fluorescent properties facilitates uptake via cell endocytosis. While this primarily focuses on recent advancements COF‐based targeted DDS, it acknowledges challenges posed diverse geometries materials discusses potential solutions. Further, underlines developing future carriers that can successfully specifically target cells, treatment efficiency while reducing adverse side effects.
Язык: Английский
Процитировано
21
Journal of Industrial and Engineering Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
3
Chemical Society Reviews, Год журнала: 2024, Номер 53(12), С. 6042 - 6067
Опубликована: Янв. 1, 2024
This review comprehensively summarizes the development of supramolecular cages as carriers and channels for cargo transport in abiotic biological systems.
Язык: Английский
Процитировано
10
Nature Synthesis, Год журнала: 2025, Номер unknown
Опубликована: Фев. 10, 2025
Abstract Covalent organic frameworks (COFs) have been developed as photosensitizers for photocatalytic energy conversion over the past decade; however, COF photocatalysts yet to demonstrate ability harvest near-infrared light (above 760 nm, approximately 53% of solar spectrum) fuel or chemical conversion. In this work we introduce a post-synthetic functionalization strategy COFs by incorporating palladacycle directly into backbone, extending absorption an azobenzene-based region. This approach enables homogeneous, atomically distributed palladium with high loading 12 wt% and without noticeable formation nanoparticles. The cyclopalladated COF, TpAzo-CPd, was used catalyst hydrogen peroxide production under 810 nm illumination. study demonstrates use photocatalysis opens door palladium-single-site catalysts wide range transformations.
Язык: Английский
Процитировано
2
Angewandte Chemie International Edition, Год журнала: 2023, Номер 63(8)
Опубликована: Ноя. 21, 2023
Nanomedicines are extensively used in cancer therapy. Covalent organic frameworks (COFs) crystalline porous materials with several benefits for therapy, including porosity, design flexibility, functionalizability, and biocompatibility. This review examines the use of COFs therapy from perspective reticular chemistry function-oriented design. First, modification sites functionalization methods discussed, followed by their potential as multifunctional nanoplatforms tumor targeting, imaging, integrating functional components. Finally, some challenges clinical translation presented hope promoting development COF-based anticancer nanomedicines bringing closer to trials.
Язык: Английский
Процитировано
22
Biomaterials Science, Год журнала: 2024, Номер 12(11), С. 2766 - 2785
Опубликована: Янв. 1, 2024
Covalent organic frameworks (COFs) constitute a class of highly functional porous materials composed lightweight elements interconnected by covalent bonds, characterized structural order, high crystallinity, and large specific surface area.
Язык: Английский
Процитировано
8
Molecules, Год журнала: 2025, Номер 30(4), С. 884 - 884
Опубликована: Фев. 14, 2025
Researchers have extensively investigated photosensitizer (PS) derivatives for various applications due to their superior photophysical and electrochemical properties. However, inherent problems, such as instability self-quenching under physiological conditions, limit biological applications. Metal-organic frameworks (MOFs) covalent organic (COFs) represent two relatively new material types. These materials high surface areas permanent porosity, they show a tremendous deal of potential like these. This review summarizes key synthesis processes highlights recent advancements in integrating PS-based COF MOF nanocarriers biomedical while addressing obstacles prospects.
Язык: Английский
Процитировано
1
Small, Год журнала: 2025, Номер unknown
Опубликована: Фев. 16, 2025
Rational design of molecular architectures is crucial for developing advanced materials such as covalent-organic frameworks (COFs) with excellent sensing performance. In this work, two isostructural COFs (β-keto-AnCOF and imine-AnCOF) the same conjugated linkers but distinct linkages are constructed. Although both have porous structure semiconductor behavior conferred by identical backbones, β-keto-AnCOF ─C═O side groups exhibits superior room-temperature ammonia (NH3) performance than imine-AnCOF even state-of-the-art dynamic commercial NH3 sensors, i.e., high sensitivity up to 18.94% ppm-1, ultralow experimental detection limit 1 ppb, outstanding selectivity, remarkable response stability reproducibility after 180 days. situ spectroscopy theoretical calculation reveal that additional charge transfer between sites in effectively increases distance Fermi level valence band, enabling highly-sensitive at ppb levels. This work provides novel next-generation high-performance sensors.
Язык: Английский
Процитировано
1