Iodoarene-directed photoredox β-C(sp3)–H arylation of 1-(o-iodoaryl)alkan-1-ones with cyanoarenes via halogen atom transfer and hydrogen atom transfer
Chemical Science,
Год журнала:
2024,
Номер
15(17), С. 6522 - 6529
Опубликована: Янв. 1, 2024
Site
selective
functionalization
of
inert
remote
C(sp
Язык: Английский
Copper-catalyzed dehydrogenative cyclization/alkenylation towards dihydroquinolinones
K. Pari,
Nawaz Khan Fazlur-Rahman
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
22(20), С. 4163 - 4171
Опубликована: Янв. 1, 2024
A
mild
and
one-pot
sequential
route
to
access
diversely
substituted
quinolinyl
dihydroquinolinones
has
been
proposed,
using
a
dehydrogenative
cyclization/alkenylation
strategy
with
good
yields.
Язык: Английский
Nickel‐Catalyzed Sequential Synthesis of Alkylated Quinolines and Their Photophysical Studies
Asian Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 20, 2024
Abstract
An
efficient
nickel‐catalyzed
sequential
one‐pot
strategy
for
the
synthesis
of
coumarin‐appended
quinolines
and
bis‐quinolines
has
been
developed
under
mild
reaction
conditions
in
moderate
to
good
yields
(up
84
%)
via
dehydrogenative
Friedlander
annulation
followed
by
C(sp
3
)−H
functionalization.
The
use
a
cost‐effective
Ni
catalyst,
environmentally
friendly
solvents
simple
operating
procedures
are
attractive
attributes
this
method.
Additionally,
photophysical
properties
synthesized
derivatives
were
explored
utilizing
UV‐vis
absorption
fluorescence
emission
studies.
Furthermore,
large‐scale
synthetic
utility
highlight
potential
applicability
organic
chemistry.
Moreover,
A
plausible
mechanism
is
supported
control
experiments
monitoring
1
H
NMR
analysis.
Язык: Английский
Design and Synthesis of Novel 4-Hydroxycoumarin-Isoxazole Adducts for Combating Bacterial Infections
Journal of Molecular Structure,
Год журнала:
2025,
Номер
unknown, С. 142668 - 142668
Опубликована: Май 1, 2025
Язык: Английский
Palladium-Catalyzed β-C(sp3)–H Arylation of Silyl Prop-1-en-1-ol Ethers with Aryl Halides: Entry to α,β-Unsaturated Ketones
Organic Letters,
Год журнала:
2023,
Номер
25(42), С. 7645 - 7649
Опубликована: Окт. 16, 2023
A
palladium(0)-catalyzed
β-C(sp3)-H
arylation
of
silyl
prop-1-en-1-ol
ethers
with
aryl
halides
for
the
synthesis
α,β-unsaturated
ketones
is
presented.
In
contrast
to
reported
ketones,
chemoselectivity
this
current
method
relies
on
Pd(0)
catalytic
systems
and
reaction
temperatures:
While
using
Pd(dba)2/DavePhos/KF
system
at
80
°C
resulted
in
monoarylation
produce
β-monoarylated
harnessing
Pd(OAc)2/t-Bu
XPhos/K2HPO4
110
induced
diarylation
afford
β,β-diarylated
ketones.
The
provides
a
versatile
route
that
uses
readily
available
ketone-derivatized
α-nonsubstituted
as
alkene
sources
characterized
by
good
functional
group
compatibility,
broad
substrate
scope,
an
excellent
selectivity.
Язык: Английский
Recent Developments on the Earth-Abundant-Metal-Catalyzed α,β-Dehydrogenation of Carbonyl Compounds
Synthesis,
Год журнала:
2023,
Номер
56(14), С. 2213 - 2222
Опубликована: Дек. 19, 2023
Abstract
α,β-Unsaturated
carbonyl
compounds
are
versatile
building
blocks
in
modern
organic
synthetic
chemistry.
In
recent
decades,
various
approaches
have
been
established
to
access
these
products,
such
as
halogenation–dehydrohalogenation
methods,
organosulfur
organoselenium
earth-abundant-metal-catalyzed
precious-metal-catalyzed
and
metal-free
etc.
Among
these,
methods
(i.e.,
iron,
cobalt,
nickel,
copper)
continue
attract
the
attention
of
chemists
because
they
readily
available,
inexpensive,
environmentally
friendly.
Presently,
there
only
a
few
reviews
covering
α,β-dehydrogenations.
Hence,
aim
this
short
review
is
provide
detailed
update
on
developments
α,β-dehydrogenations
compounds.
1
Introduction
2
Iron-Catalyzed
Dehydrogenation
3
Cobalt-Catalyzed
4
Nickel-Catalyzed
5
Copper-Catalyzed
6
Conclusion
Язык: Английский
One-Pot Sequential Synthesis of Alkenylated Dihydroquinolinones and Hexahydroacridinones in Deep Eutectic Solvent Medium
ACS Omega,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 16, 2024
The
sequential
synthesis
of
N-heterocycles
from
saturated
ketones
poses
significant
challenges
and
has
rarely
been
reported.
Herein,
an
efficient
alkenylated
dihydroquinolinones
7
hexahydroacridinones
8
is
achieved
1
or
2
via
dehydrogenation,
cyclization,
oxidation,
α-alkenylation
in
choline
chloride-based
deep
eutectic
solvent
(DES)
medium.
This
strategy
provides
excellent
yield
low-cost,
readily
available
starting
materials
under
environmentally
benign
conditions.
Furthermore,
the
synthesized
compounds
(4,
5,
7,
8)
were
investigated
for
their
photophysical
properties
through
absorption
emission
spectral
studies.
Язык: Английский
Iron-Catalyzed One-Pot Cascade Reactions of Oximes with Inactivated Saturated Ketones: Entry to Highly Substituted Pyridines
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 7, 2024
An
iron-catalyzed
oxidative
[3
+
3]
annulation
of
oxime
esters
with
inactivated
saturated
ketones
is
described.
This
cascade
strategy
allows
one-step
rapid
synthesis
various
structurally
important
pyridines
through
an
dehydrogenation/annulation/oxidative
aromatization
sequence
via
direct
α,β-dehydrogenation
simple
followed
by
oximes.
method
shows
good
functional
group
tolerance,
readily
accessible
starting
materials,
a
wide
substrate
scope,
high
chemoselectivity,
and
no
need
for
extra
stoichiometric
oxidant
also
applicable
to
the
late-stage
functionalization
natural
products.
Язык: Английский