Vitrimer-like elastomers with rapid stress-relaxation by high-speed carboxy exchange through conjugate substitution reaction
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Окт. 5, 2024
We
report
vitrimer-like
elastomers
that
exhibit
significantly
fast
stress
relaxation
using
carboxy
exchange
via
the
conjugate
substitution
reaction
of
α-(acyloxymethyl)
acrylate
skeletons.
This
network
design
is
inspired
by
a
small-molecule
model
shows
even
at
ambient
temperature
in
presence
1,4-diazabicyclo[2.2.2]octane
(DABCO).
The
and
acrylic
acid
copolymers
are
cross-linked
bis[α-(bromomethyl)acrylates]
doped
with
10
wt%
DABCO,
exhibiting
processability
to
obtain
transparent
film
hot
pressing.
high-speed
bond
network,
validated
stress-relaxation
tests,
allows
quick
molding
household
iron.
In
addition,
material
applied
as
an
adhesion
sheet
for
plastic
metal
substrates.
Because
dynamic
cross-linking
proposed
mechanism
can
be
implemented
any
polymer
bearing
carboxyl
pendants,
our
approach
versatile
backbones,
which
must
thus
meaningful
practical
sense.
Язык: Английский
Tuneable thiol exchange linkers for traceless drug release applications in prodrugs and ADCs
Chemical Communications,
Год журнала:
2024,
Номер
60(55), С. 7025 - 7028
Опубликована: Янв. 1, 2024
We
describe
a
versatile
and
tuneable
thiol
responsive
linker
system
using
thiovinylketones,
which
relies
on
the
conjugate
addition-elimination
mechanism
of
Michael
acceptors
for
traceless
release
therapeutics.
In
proof-of-principle
study,
we
translate
our
findings
to
exhibit
potent
thiol-cleavable
antibiotic
prodrugs
antibody-drug
conjugates.
Язык: Английский
Vitrimer-like Elastomers with Rapid Stress-Relaxation by High-Speed Carboxy Exchange through Conjugate Substitution Reaction
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 5, 2024
Abstract
We
report
the
design
of
vitrimer-like
elastomers
that
exhibit
fastest
stress
relaxation
(
τ
=
2
s
at
140
°C)
among
reported
poly(meth)acrylate-based
vitrimers.
The
trick
is
use
carboxy
exchange
reaction
by
conjugate
substitution
using
α-(acyloxymethyl)
acrylate
skeletons,
which
was
inspired
our
preliminary
results
in
a
small-molecule
solution
showed
progress
above
reaction,
even
ambient
temperature,
presence
1,4-diazabicyclo[2.2.2]octane
(DABCO).
To
incorporate
quick
bond
rearrangement
via
into
network,
copolymers
ethyl
and
acrylic
acid
were
crosslinked
bis[α-(bromomethyl)acrylates].
cross-linked
sample
doped
with
10
wt%
DABCO
exhibited
processability
to
obtain
transparent
film
hot
pressing,
despite
stable
rubbery
plateau
dynamic
mechanical
analysis.
high-speed
network
validated
stress-relaxation
tests,
where
speed
–10
3
times
faster
than
previously
poly(meth)acrylate
vitrimers
operated
other
common
DCBs.
significantly
fast
ability
eventually
allows
molding
household
iron.
In
addition,
present
material
applied
as
an
adhesion
sheet
for
plastics
metal
substrates.
Because
cross-linking
proposed
mechanism
implementable
any
polymers
bearing
pendants,
approach
can
be
versatile
backbones,
must
thus
meaningful
practical
sense.
Язык: Английский