Organic Letters, Год журнала: 2024, Номер 26(41), С. 8899 - 8903
Опубликована: Окт. 10, 2024
Site-selective activation of a particular remote C-H bond in molecules with multiple bonds remains challenging organic synthesis. In addition, evolving such transformations via the utilization unconventional techniques is highly desirable. We demonstrated hitherto unexplored double geometry-guided and end-on nitrile-template-assisted
Язык: Английский
The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Июнь 3, 2025
While ortho-C-H activation has been well explored, meta-C-H functionalization of phenols remains challenging due to regioselectivity constraints. Here, we introduce a site-selective olefination strategy using an aliphatic nitrile template under mild room-temperature conditions. This approach leverages nitrile-metal interactions enable efficient C-H activation, overcoming the harsh conditions required in traditional methods. With broad substrate scope and high efficiency, this method successfully applied drug-like natural product derivatives, delivering yields selectivities.
Язык: Английский
Процитировано
0
Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(5), С. 1473 - 1478
Опубликована: Янв. 1, 2024
Here, we report on a microwave-assisted accelerated meta -C–H olefination of aniline derivatives using simple aliphatic end-on nitrile assembly. Notably, the protocol shows broad substrate compatibility with remarkable regio-selectivity.
Язык: Английский
Процитировано
1
The Journal of Organic Chemistry, Год журнала: 2023, Номер 89(1), С. 433 - 451
Опубликована: Дек. 22, 2023
We present here the distal-C–H activation/functionalization of biphenyl scaffolds using aliphatic nitrile templates. The approach has demonstrated good to exclusive meta selectivities over a wide range olefination and acetoxylation substrates. In addition, bis-olefination been accomplished in one-pot, sequential manner. Notably, this technique highlights diversification pharmaceuticals natural products. Consequently, temporary directing template recovered quantitively from coupled product.
Язык: Английский
Процитировано
2
Chemistry - A European Journal, Год журнала: 2024, Номер 30(59)
Опубликована: Авг. 12, 2024
An efficient approach for the synthesis of substituted aryl naphthoquinones via a Pd(II)-catalyzed template-assisted m-C(sp
Язык: Английский
Процитировано
0
Organic Letters, Год журнала: 2024, Номер 26(41), С. 8899 - 8903
Опубликована: Окт. 10, 2024
Site-selective activation of a particular remote C-H bond in molecules with multiple bonds remains challenging organic synthesis. In addition, evolving such transformations via the utilization unconventional techniques is highly desirable. We demonstrated hitherto unexplored double geometry-guided and end-on nitrile-template-assisted
Язык: Английский
Процитировано
0