Visible-light photocatalyzed C–N bond activation of tertiary amines: a three-component approach to synthesize quinazolines
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
22(6), С. 1245 - 1253
Опубликована: Янв. 1, 2024
A
metal-free
three-component
approach
has
been
developed
to
prepare
2,4-disubstituted
quinazolines
from
Язык: Английский
Cobalt(II)-Catalyzed Synthesis of γ-Diketones from Aryl Alkenes and Its Utilization in the Synthesis of Various Heterocyclic Compounds
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(10), С. 7095 - 7108
Опубликована: Май 3, 2024
An
earth-abundant
Co(II)
salt-catalyzed
mild
and
affordable
synthetic
route
has
been
developed
for
the
synthesis
of
industrially
relevant
1,4-dicarbonyl
compounds
(or
γ-diketones)
via
oxidative
coupling
between
aryl
alkenes
ketones
(both
cyclic
acyclic)
using
TBHP
DBU
as
oxidant
base,
respectively.
1,4-Dicarbonyl
are
known
to
be
synthesized
expensive
metal
catalysts,
dual
or
low-cost
complexes
combined
with
an
additive
ligand
template,
which
further
needs
synthesized.
Herein,
we
report
cobalt(II)
acetate
a
catalyst
without
any
co-catalyst
templates.
This
methodology
broad
substrate
scope
significant
yields
good
functional
group
tolerance.
Generation
unsymmetrical
1,4-dicarbonyls
at
room
temperature
its
versatile
expansion
produce
synthetically
biologically
valuable
heterocyclic
salient
features
this
novel
methodology.
In
addition,
various
controlled
experiments
such
primary
kinetic
isotope
effect
study,
Hammett
analysis
variation
nature
substituents
on
styrene
ring,
theoretical
calculations
(density
theory)
unravel
mechanistic
intricacies
involved
in
new,
simple,
atom-economic
Язык: Английский
Ligand Enabled Manganese‐Catalyzed Oxidation of 1,2‐Disubstituted Cyclobutanols
ChemistrySelect,
Год журнала:
2024,
Номер
9(32)
Опубликована: Авг. 22, 2024
Abstract
Here
we
report
a
protocol
for
the
preparation
of
1,4‐diketones
from
1,2‐disubstituted
cyclobutanols
based
on
their
ring‐opening
oxidation
with
molecular
oxygen.
The
reaction
proceeds
under
manganese
catalysis
in
presence
1,10‐phenanthroline
ligand
and
leads
to
target
product
along
minor
4‐hydroxyketone
that
can
be
oxidized
Dess‐Martin
periodinane
same
vessel.
Substrates
alkyl
aryl
substituents
including
those
bearing
functional
groups
were
successfully
engaged
reaction.
Язык: Английский